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Negative expression of FoxO3 (zeige FOXO3 Proteine)/FoxO4 and lymph node metastasis were the risk factors for the poor prognosis of bladder cancer.
Knockdown of FOXO4 but not FOXO1 (zeige FOXO1 Proteine) expression decreased proteasome activity. Following neural differentiation, the HD-iPSC-derived neural progenitor cells (NPCs) demonstrated lower levels of proteasome activity and FOXO (zeige FOXO3 Proteine) expressions than their WT counterparts. More importantly, overexpression of FOXO4 but not FOXO1 (zeige FOXO1 Proteine) in HD NPCs dramatically enhanced proteasome activity.
Results show that a small subset of lymphoma cells surviving treatment with doxorubicin or phenylbutyrate showed stem cell-like properties and resistance to chemotherapeuty. The overexpression of FOXO4 was found in these surviving cells, and DLBCL patients with FOXO4-positive tumor cells had poor prognosis.
FOXO4 and FOXD3 (zeige FOXD3 Proteine) were shown independently predictive of overall survival in gastric cancer
FoxO1 (zeige FOXO1 Proteine) and FoxO4 antagonize Tat (zeige TAT Proteine)-mediated transactivation of HIV-1 promoter through the repression of Tat (zeige TAT Proteine) protein expression.
FOXO4 has an inhibitory effect in clearcell renal carcinoma cells, at least in part through inducing apoptosis via upregulation of Bim (zeige BCL2L11 Proteine) in the mitochondria-dependent pathway.
knockdown of Ku70 (zeige XRCC6 Proteine) inhibited cell proliferation accompanying an increase in p27(kip1 (zeige CDKN1B Proteine)) levels through interacting with FOXO4
miR (zeige MLXIP Proteine)-664 functions as an oncogene (zeige RAB1A Proteine) miRNA and has an important role in promoting human osteosarcoma cell proliferation by suppressing FOXO4 expression.
The data demonstrated that elevated miR (zeige MLXIP Proteine)-150 targets FOXO4 expression and therefore regulates multiple genes expression, resulting in cervical cancer cell growth and survival.
Porphyromonas gingivalis-induced reactive oxygen species activate FOXO (zeige FOXO3 Proteine) transcription factors through JNK (zeige MAPK8 Proteine) signalling, and that FOXO1 (zeige FOXO1 Proteine) controls oxidative stress responses, inflammatory cytokine production and cell survival.
Foxo1 (zeige FOXO1 Proteine), Foxo3a (zeige FOXO3 Proteine), and Foxo4 in chondrocytes regulate endochondral bone formation.
The effect of Sirt1 (zeige SIRT1 Proteine) stimulators on osteoclastogenesis was abrogated in cells lacking FoxO1 (zeige FOXO1 Proteine), FoxO3 (zeige FOXO3 Proteine), and FoxO4.
FoxO4 is collectively required to maintain MODYrelated gene networks, which in turn are required to enable a gene expression program that permits proper substrate selection (glucose versus fatty acids) for mitochondrial oxidative phosphorylation.
FoxO4 transcription factor is present during both oocyte and embryo in vivo maturation and FoxOs may regulate in vitro embryo development under stress conditions.
FoxO4 activates Arg1 (zeige ARG1 Proteine) transcription in endothelial cells in response to MI, leading to downregulation of nitric oxide and upregulation of neutrophil infiltration to the infarct area.
Foxo1, Foxo3, and Foxo4 transcriptional network regulates autophagy and the ubiquitin-proteasome system during muscle atrophy.
Liver-specific ablation of FoxO1 (zeige FOXO1 Proteine),FoxO3 (zeige FOXO3 Proteine) and FoxO4 prevents the induction of glucose-6-phosphatase (zeige G6PC Proteine) and the repression of glucokinase (zeige GCK Proteine) during fasting, thus increasing lipogenesis.
FOXO1 (zeige FOXO1 Proteine), FOXO3a (zeige FOXO3 Proteine) and FOXO4, are indispensable for SIRT1 (zeige SIRT1 Proteine)-dependent cell survival against oxidative stress.
FoxO1 (zeige FOXO1 Proteine)/3/4 transcription factors play important roles in hepatic glucose homeostasis.
Mice lacking Foxo1 (zeige FOXO1 Proteine), -3, and -4 in bipotential progenitors of osteoblast and adipocytes exhibit increased osteoblast number and high bone mass.
This gene encodes a member of the O class of winged helix/forkhead transcription factor family. Proteins encoded by this class are regulated by factors involved in growth and differentiation indicating they play a role in these processes. A translocation involving this gene on chromosome X and the homolog of the Drosophila trithorax gene, encoding a DNA binding protein, located on chromosome 11 is associated with leukemia. Multiple transcript variants encoding different isoforms have been found for this gene.
similar to Putative fork head domain transcription factor AFX1 (Forkhead box protein O4)
, forkhead box O4
, forkhead box protein O4-like
, fork head domain transcription factor AFX1
, forkhead box protein O4
, myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 7
, forkhead protein
, myeloid/lymphoid or mixed lineage-leukemia translocation to 7 homolog
, forkhead box O1A