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FOXO1 (zeige FOXO1 Proteine), 3, and 4 as well as their upstream regulator, AKT/p-AKT (zeige AKT1 Proteine), was examined in rhesus macaque ovaries of three developmental stages: fetal, prepubertal, and adult
Study reports that CK1alpha similarly destabilizes FOXO4 in RAS-mutant cells by phosphorylation at serines 265/268.
In this review, we introduce the regulation of FOXO4 in physiological and pathological conditions. Particularly, the pathophysiological processes and molecular pathways regulated by FOXO4 in the development and progression of cancer are also summarized
The results of this genomic analysis suggest that low FOXO4 expression is a significant risk factor for epileptic seizures in patients with LGGs and is associated with the seizure outcome.
NF-kappaB (zeige NFKB1 Proteine)/snail (zeige SNAI1 Proteine)/YY1 (zeige YY1 Proteine)/RKIP (zeige PEBP1 Proteine) circuitry regulated by FOXO4 were likely involved in miR (zeige MLXIP Proteine)-150-induced EMT (zeige ITK Proteine) event.
Negative expression of FoxO3 (zeige FOXO3 Proteine)/FoxO4 and lymph node metastasis were the risk factors for the poor prognosis of bladder cancer.
Knockdown of FOXO4 but not FOXO1 (zeige FOXO1 Proteine) expression decreased proteasome activity. Following neural differentiation, the HD-iPSC-derived neural progenitor cells (NPCs) demonstrated lower levels of proteasome activity and FOXO (zeige FOXO3 Proteine) expressions than their WT counterparts. More importantly, overexpression of FOXO4 but not FOXO1 (zeige FOXO1 Proteine) in HD NPCs dramatically enhanced proteasome activity.
Results show that a small subset of lymphoma cells surviving treatment with doxorubicin or phenylbutyrate showed stem cell-like properties and resistance to chemotherapeuty. The overexpression of FOXO4 was found in these surviving cells, and DLBCL patients with FOXO4-positive tumor cells had poor prognosis.
FOXO4 and FOXD3 (zeige FOXD3 Proteine) were shown independently predictive of overall survival in gastric cancer
FoxO1 (zeige FOXO1 Proteine) and FoxO4 antagonize Tat (zeige TAT Proteine)-mediated transactivation of HIV-1 promoter through the repression of Tat (zeige TAT Proteine) protein expression.
FOXO4 has an inhibitory effect in clearcell renal carcinoma cells, at least in part through inducing apoptosis via upregulation of Bim (zeige BCL2L11 Proteine) in the mitochondria-dependent pathway.
Foxo1 (zeige FOXO1 Proteine), Foxo3a (zeige FOXO3 Proteine), and Foxo4 in chondrocytes regulate endochondral bone formation.
The effect of Sirt1 (zeige SIRT1 Proteine) stimulators on osteoclastogenesis was abrogated in cells lacking FoxO1 (zeige FOXO1 Proteine), FoxO3 (zeige FOXO3 Proteine), and FoxO4.
FoxO4 is collectively required to maintain MODYrelated gene networks, which in turn are required to enable a gene expression program that permits proper substrate selection (glucose versus fatty acids) for mitochondrial oxidative phosphorylation.
FoxO4 transcription factor is present during both oocyte and embryo in vivo maturation and FoxOs may regulate in vitro embryo development under stress conditions.
FoxO4 activates Arg1 (zeige ARG1 Proteine) transcription in endothelial cells in response to MI, leading to downregulation of nitric oxide and upregulation of neutrophil infiltration to the infarct area.
Foxo1, Foxo3, and Foxo4 transcriptional network regulates autophagy and the ubiquitin-proteasome system during muscle atrophy.
Liver-specific ablation of FoxO1 (zeige FOXO1 Proteine),FoxO3 (zeige FOXO3 Proteine) and FoxO4 prevents the induction of glucose-6-phosphatase (zeige G6PC Proteine) and the repression of glucokinase (zeige GCK Proteine) during fasting, thus increasing lipogenesis.
FOXO1 (zeige FOXO1 Proteine), FOXO3a (zeige FOXO3 Proteine) and FOXO4, are indispensable for SIRT1 (zeige SIRT1 Proteine)-dependent cell survival against oxidative stress.
FoxO1 (zeige FOXO1 Proteine)/3/4 transcription factors play important roles in hepatic glucose homeostasis.
Mice lacking Foxo1 (zeige FOXO1 Proteine), -3, and -4 in bipotential progenitors of osteoblast and adipocytes exhibit increased osteoblast number and high bone mass.
This gene encodes a member of the O class of winged helix/forkhead transcription factor family. Proteins encoded by this class are regulated by factors involved in growth and differentiation indicating they play a role in these processes. A translocation involving this gene on chromosome X and the homolog of the Drosophila trithorax gene, encoding a DNA binding protein, located on chromosome 11 is associated with leukemia. Multiple transcript variants encoding different isoforms have been found for this gene.
similar to Putative fork head domain transcription factor AFX1 (Forkhead box protein O4)
, forkhead box O4
, forkhead box protein O4-like
, fork head domain transcription factor AFX1
, forkhead box protein O4
, myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 7
, forkhead protein
, myeloid/lymphoid or mixed lineage-leukemia translocation to 7 homolog
, forkhead box O1A