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Results show that CDCA8 is overexpressed in bladder cancer (BC) and its high levels are correlated with poor clinicopathological features of BC patients. Therefore, CDCA8 may act as a novel prognostic marker in the diagnosis of patients with BC.
These results were well correlated with the same gene expression pattern analysed in the thyroid tissue of the patient with BOREALIN-p.R114W. These studies open new avenues in the genetics of TD in humans.
Borealin dimerization mediates chromosomal passenger complex checkpoint function by enhancing localization to centromeres and kinetochores.
enhanced CDCA8 promoter activities by NF-Y overexpression and reduced CDCA8 transcription by NF-Y knockdown further verified that NF-Y is a positive regulator of CDCA8 transcription.
In colorectal cancer patients, Borealin expression was positively correlated with age, lymph node metastasis and neoplasm staging.
These findings reveal a previously unrecognized but direct link between HP1 (zeige DEFA1 Proteine) and CPC localization in the centromere and illustrate the critical role of borealin-HP1 (zeige DEFA1 Proteine) interaction in orchestrating an accurate cell division.
Borealin interacts directly with the Snf7 components of ESCRT-III in human cells.the Borealin central region encompassing residues 110-207 was both necessary & sufficient to bind to CHMP4C.
MLL5 functionally interacts with Borealin, facilitates the expression of chromosomal passenger complex, and hence contributes to mitotic fidelity and genomic integrity.
important role for phosphorylation of Borealin at S219 in the proper progression through mitosis
Data show that INCENP (zeige INCENP Proteine) has an important role in stabilizing the chromosomal passenger complex, and that Borealin acts to promote binding of Survivin to INCENP (zeige INCENP Proteine).
Borr interacts and colocalizes with the ESCRT-III component Shrb in Drosophila cells.
These findings indicate that Borealin plays a key role in liver development, regeneration, and tumorigenesis and suggests that Borealin could be a potential target for related liver diseases.
Borealin plays a crucial role in the early mouse embryonic development
Borealin/DasraB is essential for cell proliferation during early embryonic development, and its early embryonic lethality cannot be rescued by the loss of p53 (zeige TP53 Proteine)
This gene encodes a component of the chromosomal passenger complex. This complex is an essential regulator of mitosis and cell division. This protein is cell-cycle regulated and is required for chromatin-induced microtubule stabilization and spindle formation. Alternate splicing results in multiple transcript variants. Pseudgenes of this gene are found on chromosomes 7, 8 and 16.
, cell division cycle-associated protein 8
, pluripotent embryonic stem cell-related gene 3 protein
, Cell division cycle-associated protein 8
, embryonic stem cell-related
, chromosomal passenger complex protein Dasra B
, cell division cycle associated 8