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Mdm2 (zeige MDM2 ELISA Kits) overexpression and Cdc25C downregulation delay cell cycle progression through the G2/M phase.
Xanthatin functions as a DNA-damaging agent in non-small cell lung carcinomas by activating Chk1 (zeige CHEK1 ELISA Kits)-mediated DDR (zeige DDR1 ELISA Kits) and lysosome-mediated degradation of Cdc25C.
Myelodysplastic syndrome -related P95 (zeige NBN ELISA Kits) point mutants of SRSF2 (zeige SRSF2 ELISA Kits) lead to alternative splicing of CDC25C in a manner that is not dependent on the DNA damage response.
The aim of this review is to shed light on the role of four different phosphatases (PTEN, PP2A (zeige PPP2R4 ELISA Kits), CDC25 (zeige RASGRF1 ELISA Kits) and DUSP1 (zeige DUSP1 ELISA Kits)) in five different solid tumors (breast cancer, lung cancer, pancreatic cancer, prostate cancer and ovarian cancer), in order to better understand the most frequent and aggressive primary cancer of the central nervous system, glioblastoma.
Data show that TRIB2 (zeige TRIB2 ELISA Kits)-mediated degradation of CDC25C is associated with lysine-48-linked CDC25C polyubiquitination driven by the TRIB2 (zeige TRIB2 ELISA Kits) kinase-like domain.
the biology of the activation/deactivation of CDC25 (zeige RASGRF1 ELISA Kits) by kinases/phosphatases to maintain the level of CDK (zeige CDK4 ELISA Kits)-cyclin (zeige PCNA ELISA Kits) activities and thus the genomic stability
the knockdown of CDC25C can reduce both the radiotherapy sensitivity and the proliferation activity of EC9706 cells.
results identify CDC25C as a downstream target of the mutated tyrosine kinase (zeige TXK ELISA Kits) FLT3 (zeige FLT3 ELISA Kits)-ITD affecting cell-cycle regulation in a model of AML (zeige RUNX1 ELISA Kits)
Suggest that the p53 (zeige TP53 ELISA Kits)-p21 (zeige CDKN1A ELISA Kits)-DREAM-CDE/CHR pathway regulates p53 (zeige TP53 ELISA Kits)-dependent repression of Survivin (zeige BIRC5 ELISA Kits), CDC25C, and PLK1 (zeige PLK1 ELISA Kits) in HCT116 cells.
Data indicate that nine compounds were identified with Ki values for CDC25A, -B and -C ranging from 0.01 to 4.4 muM.
oxidative stress-induced (zeige SQSTM1 ELISA Kits) DNA damage of mouse zygotes triggers the cell cycle checkpoint, which results in G2/M cell cycle arrest, and that phospho-Cdc25B (zeige CDC25B ELISA Kits) (Ser323), phospho-Cdc25C (Ser216), and phospho-Cdc2 (zeige CDK1 ELISA Kits) (Tyr15) participate in activating the G2/M checkpoint.
The role of Cdc25c and Cdc25b (zeige CDC25B ELISA Kits) in activating G2/M cell cycle checkpoint in zygote.
an asymmetrical distribution pattern for Cdc25c transcripts in 2-cell embryos.
CDC25A (zeige CDC25A ELISA Kits) and CDC25B (zeige CDC25B ELISA Kits) but not CDC25C compensate for each other to maintain the proliferative capacity of intestinal epithelial stem and progenitor cells
A single cell cycle genes homology region controls transcription of the cdc25C gene and is able to cooperate with E2F (zeige E2F1 ELISA Kits) or Sp1 (zeige SP1 ELISA Kits)/3 sites
Cdc25A (zeige CDC25A ELISA Kits), or possibly other phosphatases, is able to functionally compensate for the loss of Cdc25B (zeige CDC25B ELISA Kits) and Cdc25C in mice
The present study was aimed to investigate the possibility that selenium (Se)-induced oxidative stress mediated alterations in Cdc25c and p21 may cause modulations in the CDC2 (zeige CDK1 ELISA Kits)/Cyclin B1 (zeige CCNB1 ELISA Kits) complex responsible for G2/M phase checkpoint in spermatogenesis.
In Lzts1 (zeige LZTS1 ELISA Kits)(-/-) mouse embryo fibroblasts (MEFs), Cdc25C degradation was increased during M phase, resulting in decreased Cdk1 (zeige CDK1 ELISA Kits) activity.
PP2A:B56delta as a key upstream regulator of Cdk1 (zeige CDK1 ELISA Kits) activity upon exit from mitosis
Blocking mitotic entry by adding the catalytic subunit of protein kinase A results in increased wee1 Ser549 phosphorylation and maintenance of cdc25C.
These observations identify PP2A/B56delta as a central checkpoint effector and suggest a mechanism for controlling 14-3-3 (zeige YWHAQ ELISA Kits) interactions to promote mitosis.
In Xenopus oocytes, p42 MAPK (zeige MAPK1 ELISA Kits) interacts with hypophosphorylated Cdc25 before meiotic induction. During meiotic induction, p42 MAPK (zeige MAPK1 ELISA Kits) phosphorylates Cdc25 at three sites, increasing Cdc25's phosphatase activity.
This gene is highly conserved during evolution and it plays a key role in the regulation of cell division. The encoded protein is a tyrosine phosphatase and belongs to the Cdc25 phosphatase family. It directs dephosphorylation of cyclin B-bound CDC2 and triggers entry into mitosis. It is also thought to suppress p53-induced growth arrest. Multiple alternatively spliced transcript variants of this gene have been described, however, the full-length nature of many of them is not known.
cell division cycle 25 homolog C (S. pombe)
, m-phase inducer phosphatase 3-like
, cell division cycle 25 homolog C
, cell division cycle 25C
, Dual specificity phosphatase Cdc25C
, M-phase inducer phosphatase 3
, dual specificity phosphatase Cdc25C
, dual specificity phosphatase CDC25C
, mitosis inducer CDC25
, phosphotyrosine phosphatase
, protein phosphatase 1, regulatory subunit 60
, cell cycle phosphatase CDC25C
, cell division cycle control protein 25C