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Caudal Wnt8a is expressed only early somite stages. It is needed for normal anterior trunk development in the absence of Wnt3a. Wnt8a and Wnt3a cooperate to maintain Fgf8 expression and stop premature Sox2 up-regulation in the axial stem cell niche.
Wnt8a expression depends on the presence of Fgf3 indicating a serial regulation between Fgf and Wnt signalling during otic placode induction and specification.
demonstrate that both the enlargement of the otic placode and the expansion of the Wnt8a expression domain can be rescued in Spry1/; Spry2/ embryos by reducing the gene dosage of Fgf10
FGF signaling regulates otic placode induction and refinement by controlling both ectodermal target genes and hindbrain Wnt8a.
Developmental regulation of this protein is involved in cardiac myogenesis
The Wnt8A expression was evaluted in the resultant Tg(CAG-mWnt8A) embryos to identify mWnt8A misexpression.
Here, we show that Wnt/planar cell polarity (PCP) autocrine signaling controls the emergence of cytonemes, and that cytonemes subsequently control paracrine Wnt/beta-catenin signal activation. Upon binding of the Wnt family member Wnt8a, the receptor tyrosine kinase Ror2 becomes activated.
the WNT8A gene is involved in the susceptibility to HSCR, and plays an important role in the occurrence and development of Hirschsprung's disease.
Expression and regulation of WNT8A mRNA in human tumor cell lines
In the Wnt-receiving cells, Wnt8a on cytonemes triggers Wnt/beta-catenin-dependent gene transcription and proliferation. We show that cytoneme-based Wnt transport operates in diverse processes, including zebrafish development, murine intestinal crypt and human cancer organoids, demonstrating that Wnt transport by cytonemes and its control via the Ror2 pathway is highly conserved in vertebrates
The results demonstrate that the argon plasma jet has no adverse effects on fin regeneration and embryogenesis in zebrafish, and does not interrupt the (Wnt)/beta-Catenin-signaling pathways.
These results indicated that maternal wnt8a is dispensable for the initial dorsal determination, but cooperates with zygotic wnt8a for ventrolateral and posterior tissue formation.
Wnt signaling balances specification of the cardiac and pharyngeal muscle fields.
Data suggest that Wnt3, Wnt3a, and Wnt8a bind to their respective receptors (Fz8, Lrp6, and Lypd6) in ordered plasma membrane environments; ordered plasma membrane environments appear to be essential for binding of Wnt proteins to their receptor complexes and stimulation of downstream signaling activity.
Wnt8, in addition to its well-established role in posterior mesoderm patterning, also plays a later role as a factor that expands the renal progenitor pool prior to kidney morphogenesis.
Cortical depth and differential transport of vegetally localized dorsal and germ line determinants, Wnt8a, grip2a, and Dazl, in the zebrafish embryo have been presented.
Gain of function of Wnt8a results in the accumulation of beta-catenin into the nuclei of all cells of the gastrula from the margin to the animal pole.
A filopodia-based transport system for Wnt8a controls anteroposterior patterning of the neural plate during vertebrate gastrulation.
Wnt limits its own signaling activity in part via up-regulation of a transporter, slc35c1 that promotes terminal fucosylation and thereby limits Wnt activity.
Dynamic association with donor cell filopodia and lipid-modification are essential features of Wnt8a during patterning of the zebrafish neuroectoderm.
post-transcriptional control of wnt8a is essential to fine tune the balance of the signaling outputs of the complex wnt8a locus, which is essential to zebrafish axis development
A novel role for Eaf1 and Eaf2 in inhibiting canonical Wnt/beta-catenin signaling, which might form the mechanistic basis for Eaf1 and Eaf2 tumor suppressor activity.
Wnt8a expression pattern reflects complex interactions of multiple regulatory inputs.
2-OST functions within the Wnt pathway, downstream of Wnt ligand signaling and upstream of Gsk3beta and beta-catenin intracellular localization and function
It was shown that Wnt3a-Wnt8a/beta-catenin signaling directly regulates ciliogenic transcription factor foxj1a expression and ciliogenesis in zebrafish Kupffer's vesicle.
Data show that the maternal dorsal determinant, Wnt8a, is required to localize the primary dorsal center, and that the extent of this domain is defined by the activity of two maternally provided Wnt antagonists, Sfrp1a and Frzb.
wnt8a expression marks Nodal-independent tail mesoderm formation and that Ntl/Bra predominantly regulates wnt8a in paraxial mesoderm progenitors.
Kzp controls canonical Wnt8 signaling to modulate dorsoventral patterning during zebrafish gastrulation
Wnt8 and BMP signaling have independent roles during vertebrate ventrolateral mesoderm development that can be identified through loss-of-function analysis.
The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family, and may be implicated in development of early embryos as well as germ cell tumors. It encodes a protein which shows 81% amino acid identity to the mouse Wnt8A protein.
wingless-type MMTV integration site family, member 8A
, protein Wnt-8a
, protein Wnt-8a-like
, protein Wnt-8d
, stimulated by retinoic acid gene 11 protein
, wingless-related MMTV integration site 8D
, wingless-related MMTV integration site 8A
, protein Wnt-8a ORF1
, protein Wnt-8c