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Wnt7a has a role in postmenstrual regeneration and proliferation of endometrial glands and luminal epithelium in primates
Study showed that Wnt7a in the medial insular cortex was significantly increased after 28days of morphine withdrawal, and specific down-regulation of Wnt7a alleviated the anxiety-like behavior.
experiments define the extent of CNS region-specific cooperation for several components of the Norrin and Wnt7a/Wnt7b systems, and they reveal substantial regional heterogeneity in the extent to which partially redundant ligands, receptors, and coactivators maintain the blood-brain barrier and blood-retina barrier
Celsr3 and Fzd3 enable immature neurons to respond to Wnt7, upregulate Jag1 and thereby facilitate feedback signals that tune the timing of neural progenitor cell fate decisions via Notch activation.
We identified Wnt7A and Wnt7B as major Wnts for nerve terminal development in rescue experiments. These observations demonstrate a necessary role of motoneuron Wnts in neuromuscular junction (NMJ) development, in particular presynaptic differentiation
Wnt7a induces a unique phenotype of monocyte-derived macrophages with lower phagocytic capacity and differential expression of pro- and anti-inflammatory cytokines
experiments indicate that Reck and Gpr124 are part of the cell surface protein complex that transduces Wnt7a- and Wnt7b-specific signals in mammalian CNS epithelial cells to promote angiogenesis and regulate the BBB
WNT7a is sufficient to restore post-pubertal endometrial gland formation.
we found that post-ejaculated semen from fertile wild-type males was solidified and the sperm were entrapped in Wnt7aCre/+;Esr1f/f uteri, compared to the watery semen (liquefied) found in Esr1f/f controls.Kallikrein-related peptidases 3 (KLK3) and other kallikrein-related peptidases from male prostate glands are responsible for semen liquefaction by cleaving gel-forming proteins
Data show that the WIF domain of Wnt Inhibitory Factor 1 (WIF1) is bound by C-terminal domains of Wnt proteins Wnt5a and Wnt7a at two sites.
Wnt7a is a novel regulator of ventral midbrain neurogenesis and dopaminergic neuron axon growth and guidance.
Truncated Wnt7a lacking the conserved palmitoylation sites retains full biological activity in skeletal muscle.
epithelial Wnt7a and Wnt7b are possible ligands of Fzd-mediated beta-catenin (Ctnnb1)-dependent (canonical) Wnt signaling in the adjacent undifferentiated periotic mesenchyme of fibrocytes in the murine inner ear
Binding of Wnt7a to Fzd7 leads to an activation of noncanonical Wnt signaling, resulting in directed myogenic stem cell migration and enhanced engraftment.
Wnt7a triggers melanocyte stem cell differentiation through beta-catenin activation, and Kitl might induce following migration of melanoblasts to epidermis
Wnt7a exercised critical control over multiple steps of neurogenesis by regulating genes involved in both cell cycle control and neuronal differentiation.
FN and Wnt7a together regulate the homeostatic levels of satellite stem cells and satellite myogenic cells during regenerative myogenesis.
Hyperactivated c-Met led to increased NF-kappaB signaling, which in turn, drove de novo expression of Wnt7a and overexpression of Wnt7b in Pkd1(-/-) mouse kidneys.
Our data demonstrate that Wnt7a is the earliest known gamma-motor neuron marker
These results indicate that WNT7A plays a critical role in postnatal uterine gland morphogenesis and function, which are important for blastocyst implantation and fertility in the adult uterus.
Data show that female Wnt7a-Cre(+)PR(f/-) mice are infertile due to defects in embryo attachment, stromal cell decidualization, and the inability to cease estrogen-induced epithelial cell proliferation.
results have identified an miR-370-3p/Wnt7a axis that controls UBC invasion through canonical Wnt/beta-catenin signaling, which may offer prognostic and therapeutic opportunities
All exons of WNT7a in 570 schizophrenic patients and 563 controls were sequenced, but none were noted to be associated with schizophrenia.
These results indicate that Wnt7a signaling inhibits inflammatory stimuli-induced catabolic gene expression in human articular chondrocytes and is sufficient to attenuate MMP activities and promote joint cartilage integrity in mouse experimental OA, demonstrating a novel effect of Wnt7a on regulating OA pathogenesis.
This report deals with linkage studies and exome sequencing, disclosing a novel variant in WNT7A, c.934G>A (p.Gly312Ser), as the cause of this Santos syndrome.
Demonstrate a significant change in miRNA profile dependent on the assisted reproductive technology outcome affecting Wnt pathway.
A homozygous novel WNT7A mutation was identified in a child with Al-Awadi-Raas-Rothschild syndrome accompanied by dental abnormalities and his parents with dental abnormalities.
Activation of the WNT/CTNBB1 pathway via WNT7A might play a role in PTC development.
Results show that Wnt7a expression is significantly upregulated in epithelial cells of ovarian cancer which correlates with STAT4 expression and provide evidence that STAT4 promotes ovarian cancer metastasis via tumor-derived Wnt7a-induced activation of cancer-associated fibroblasts.
WNT7A is a direct target of miR-15b in ovarian cancer cell line.
The findings presented in this fetus are compatible with diagnosis of Al-Awadi-Raas-Rothschild syndrome , expanding the mutational spectrum of limb malformations arising from defects in WNT7A
Wnt7a is involved in the transformation of the retinal pigment epithelium.
Wnt7a overexpression is associated with an unfavorable prognosis and that positive Wnt7a may be an independent prognosis factor influencing OS and DFS prediction in colorectal cancer patients.
identified Iloprost, a prostacyclin analog, which initiates downstream signaling cascades similar to that of Wnt7a, as a novel inducer of cellular senescence, presenting potential future clinical translational strategies
Prognosis was significantly more favorable for patients with high Wnt7A expression.
loss of the Wnt7a gene induced by promoter methylation might be a prognostic factor for non-small cell lung carcinoma
this is the first study reporting reduced WNT7A levels in cervical cancer -derived cells and that ectopic WNT7A restoration negatively affects cell proliferation and migration.
Wnt7a has a role in specifying the fate of neural crest-like cells via suppression of notch in the human skin microenvironment
findings suggest a central role of the WNT7A-PAX6 axis in corneal epithelial cell fate determination, and point to a new strategy for treating corneal surface diseases
Wnt7a haplotype 1 had the highest haplotype frequencies and was highly significantly associated with body height, body weight, chest width and height at hip cross.
This gene is a member of the WNT gene family, which consists of structurally related genes that encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is involved in the development of the anterior-posterior axis in the female reproductive tract, and also plays a critical role in uterine smooth muscle pattering and maintenance of adult uterine function. Mutations in this gene are associated with Fuhrmann and Al-Awadi/Raas-Rothschild/Schinzel phocomelia syndromes.
, wingless-type MMTV integration site family, member 7A
, postaxial hemimelia
, proto-oncogene Wnt7a protein
, wingless-related MMTV integration site 7A
, wingless-type MMTV integration site 7A
, Protein Wnt-7a
, wnt-1 related (wnt-7a), wingless-type MMTV integration site family
, protein Wnt-7a-like