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Human WNT2 Protein expressed in Wheat germ - ABIN1325356
Habuchi, Nagai, Sugaya, Atsumi, Stevens, Kimata: Mice deficient in heparan sulfate 6-O-sulfotransferase-1 exhibit defective heparan sulfate biosynthesis, abnormal placentation, and late embryonic lethality. in The Journal of biological chemistry 2007
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We discovered an otk paralog (otk2, CG8964), which is co-expressed with otk throughout embryonic and larval development. Otk and Otk2 bind to each other and form complexes with Frizzled, Frizzled2 (zeige FZD2 Proteine) and Wnt2, pointing to a function as Wnt (zeige WNT4 Proteine) co-receptors.
Mutations in Wnt2 alter presynaptic motor neuron morphology and presynaptic protein localization at the neuromuscular junction.
DWnt-2 promotes correct patterning of direct flight muscles through a mechanism that is independent of the attachment site differentiation initiated by stripe.
Data show that Drosophila Naked cuticle (Nkd (zeige NKD1 Proteine)) engages the nuclear import adaptor Importin-alpha3 to antagonize Wnt (zeige WNT4 Proteine)/beta-catenin signaling.
It activates beta-catenin-independent pathway, such as planar cell polarity pathway, calcium signaling. (review)
Transient expression of WNT2 promotes somatic cell reprogramming by inducing beta-catenin (zeige CTNNB1 Proteine) nuclear accumulation.
Study indicates essential roles for Wnt2 and Wnt3 (zeige WNT3 Proteine) in chronic restraint stress-induced depression-like behaviors and antidepressant.
Upregulation of Wnt2 expression enhanced WISP-1 (zeige WISP1 Proteine) and promoted vascular smooth muscle cell migration and intimal thickening.
Wnt 2 levels were markedly down-regulated by retinoic acid in pancreatic stellar cells and chronic pancreatitis.
We propose that the WNT2/CTNNB1 (zeige CTNNB1 Proteine) pathway regulates CX43 (zeige GJA1 Proteine) expression and gap junction intercellular communication in granulosa cells by modulating CTNNB1 (zeige CTNNB1 Proteine) stability and localization in adherens junctions
Pdgf (zeige PDGFA Proteine) signaling potentiates Wnt2-Wnt7b (zeige WNT7B Proteine) signaling to promote high levels of Wnt activity in mesenchymal progenitors that is required for proper development of endoderm-derived organs, such as the lung
Expression of WNT2 in pancreatic cancer cells suppresses anoikis, enhances anchorage-independent sphere formation, and increases metastatic propensity in vivo.
Wnt2 plays strong positive stage-specific role in cardiogenesis through non-canonical Wnt pathway in murine ES cells.
show that Wnt2 signaling is necessary and sufficient for activation of a transcriptional and signaling network critical for smooth muscle specification and differentiation including myocardin/Mrtf-B (zeige MKL2 Proteine) and the signaling factor Fgf10 (zeige FGF10 Proteine)
Wnt2 expression is downregulated at lung bud stage in the nitrofen model. Optical projection tomography is potentially a useful approach to visualize both gene expression and morphology during very early stages of lung development.
Three-dimensional organotypic co-culture assays revealed that WNT2-mediated fibroblast motility and extracellular matrix remodeling enhanced cancer cell invasion of cell lines even harboring mutations in the adenomatous polyposis coli (zeige APC Proteine)/beta-catenin (zeige CTNNB1 Proteine) pathway.
Chondrogenic potential was higher and Wnt/beta-catenin signaling was more potently activated by a GSK-3beta inhibitor in the posterior than in the anterior part of the human infant sclera.
data enforced the evidence that knockdown of c-Fos inhibited cell proliferation, migration, and invasion, and promoted the apoptosis of OS cells accompanied by altered expression of Wnt2 and Fzd9
High WNT2 expression is associated with Cervical Carcinoma Metastasis.
targeting beta-catenin with lipofection-delivered small interfering RNA oligonucleotide inhibited the proliferation and cell cycle arrest in G0/G1 phase and increased apoptosis of fibroblast cells, accompanied by downregulation of Wnt2 and cyclin D1 as well as the phosphorylation level of glycogen synthase kinase 3 beta in the keloid fibrosis
Genetic polymorphisms in the WNT2 and CTNNB1 genes were closely associated with hepatocellular carcinoma risk and progression in a Chinese Han population
The WNT2 rs39315 G allele was associated with advanced tumor stage in hepatocellular carcinoma.
Wnt2 complements Wnt/beta-catenin (zeige CTNNB1 Proteine) signaling in regulating colorectal cancer cell proliferation.
Wnt2/beta-catenin (zeige CTNNB1 Proteine) signaling was involved in stromal-epithelial cells interaction in endometriosis.
High expression of Wnt2 is associated with pancreatic cancer progression promoted by pancreatic stellate cells.
WNT2 gene is associated with resistance to paratuberculosis
These data demonstrate for the first time that FSH (zeige BRD2 Proteine) regulates CTNNB1 (zeige CTNNB1 Proteine) protein and WNT2 mRNA expressions in bovine granulosa cells, suggesting a potential role of canonical WNT signaling in ovarian steroidogenesis and follicular growth of cattle.
show that sequential functions of Wnt2bb and Wnt2 control liver specification and proliferation in zebrafish
This gene is a member of the WNT gene family. The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. Alternatively spliced transcript variants have been identified for this gene.
, wingless-type MMTV integration site family member 2
, INT-1-related protein
, protein Wnt-2
, Int-1-related protein
, int-1-like protein 1
, secreted growth factor
, wingless-related MMTV integration site 2
, wingless-type MMTV integration site 2
, protein Wnt-2-like
, Protein Wnt-2