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apically localized serine/threonine kinase aPKC directly phosphorylates an N-terminal site of the cell-cycle inhibitor p27Xic1 and reduces its ability to inhibit the cyclin-dependent kinase 2 (zeige CDK2 Proteine), leading to shortening of G1 and S phases
Neural induction by Syn4 (zeige SNTG1 Proteine) through the PKC pathway requires inhibition of PKCdelta (zeige PKCd Proteine) and activation of PKCalpha.
The depletion of membrane PIP(2) underlies receptor-mediated inhibition of IKs and that phosphorylation by PKC of the KCNE1 (zeige KCNE1 Proteine) subunit underlies the GqPCR-mediated channel activation.
Our data demonstrate isoform-specific regulation of closed-state inactivation by protein kinase C in Kv4.3 (zeige KCND3 Proteine)
Data show that PKC staining colocalizes with monkey retina expresses a retina-specific slice variant of PCP2.
high expression of both PLCE1 (zeige PLCE1 Proteine) and PRKCA is significantly associated with poor outcomes of the patients with esophageal cancers.
In nasopharyngeal carcinoma, PKCalpha is linked to the invasion of adjacent tissues, especially in the skull base. Down-regulation of PKCalpha is a risk factor for regional lymph node metastasis.
LAV-BPIFB4 (zeige BPIFB4 Proteine) isoform modulates eNOS (zeige NOS3 Proteine) signalling through Ca2 (zeige CA2 Proteine)+/PKC-alpha-dependent mechanism.
Studied interactions between protein kinase C alpha (PKCalpha), FOXC2 (zeige FOXC2 Proteine), and p120-catenin (CTNND1 (zeige CTNND1 Proteine)) in breast cancer, cell migration/ invasion; found PKCalpha acts as an upstream regulator of FOXC2 (zeige FOXC2 Proteine), which in turn represses the expression of p120-catenin (zeige CTNND1 Proteine), in both in endocrine resistant ER+breast cancer and basal A triple negative breast cancer
Phosphorylated PKCalpha is elevated in epidermis genetically deleted of DLX3 (zeige DLX3 Proteine) and the hyperproliferative response to TPA (zeige PLAT Proteine) is increased, suggesting that the homeobox protein indirectly regulates the activity in the pathway, possibly through an effect on reduced phosphatase expression
Results show that PKCalpha expression is under the regulation of miR (zeige MLXIP Proteine)-142-3p contributing to reduced osteoclasts survival.
Molecular Determinants for the Binding Mode of Alkylphosphocholines in the C2 Domain of PKCalpha.
Studies suggest that rare deleterious variants of PARD3 (zeige PARD3 Proteine) in the aPKC-binding region contribute to human cranial neural tube defect (NTD).
study identified PKCalpha as hepatitis E virus HEV in host defense
ADP inhibits mesothelioma cell proliferation via PKC-alpha/ERK (zeige EPHB2 Proteine)/p53 (zeige TP53 Proteine) signaling.
Results show that de novo polarisation of the embryo at the 8-cell stage is directed by phospholipase C (PLC) and protein kinase C (PKC).
However, the mechanism that induces release of IL-6 (zeige IL6 Proteine) from skeletal muscle cells remains unknown. Here we show that heat increases IL-6 (zeige IL6 Proteine) in skeletal muscle cells through the transient receptor potential vannilloid 1, PKC, and cAMP response element-binding protein signal transduction pathway.
protein kinase (zeige CDK7 Proteine) Calpha (zeige PRKACA Proteine) (PKCalpha) gain of function mutations may promote synaptic defects in Alzheimer's disease
Erk5 MAP kinase is activated in response to PDGF-BB in the smooth muscle cell line MOVAS in a manner dependent on Mekk2, Mek1/2, Mek5, PI3-kinase and protein kinase C (PKC).
PKC-alpha plays a crucial role in the pathophysiology of peritoneal membrane dysfunction induced by peritoneal dialysis fluids, and its therapeutic inhibition might be a valuable treatment option for peritoneal dialysis patients.
these results identify PKCalpha and HMGB1 as important co-regulators involved in hydrogen peroxide-induced poly-ADP-ribose formation.
the present study demonstrates that nNOS-derived NO signaling modulated by spinal Sig-1R activation increases Nox2 activity and concomitant ROS production, which leads to a ROS-induced increase in PKC-dependent pGluN1 expression in the spinal cord dorsal horn and the development of pain hypersensitivity
We conclude that synaptotagmin-1 (zeige SYT1 Proteine) phosphorylation is an essential step in PKC-dependent potentiation of synaptic transmission, acting downstream of the two other essential DAG/PKC substrates, Munc13-1 and Munc18-1 (zeige STXBP1 Proteine).
These data indicate that LPA increases CCN2 (zeige CTGF Proteine) expression through the activation of PKC and PKA. Thus, the regulatory functions of the PKC and PKA pathways are implicated in the LPA-induced increase in CCN2 (zeige CTGF Proteine) expression
PKC activation can enhance hippocampal neurotransmitter release, depending on changes specific to mGluR5 (zeige GRM5 Proteine) and AMPA (zeige GRIA3 Proteine)/kainate receptors.
Isoenzymes beta and delta of PKC have been found significantly phosphorylated, although their location was not changed as a consequence of Trichinella spiralis infection.
AngII activates PKD via a mechanism involving Src family kinases and PKC, to underlie increased aldosterone production.
Significant changes in thin filament Ca2 (zeige CA2 Proteine)+-sensitivity, structure and kinetics are brought about through PKC phosphorylation of cardiac troponin T (zeige TNNT2 Proteine).
Data indicate the involvement of PKC-alpha in proMMP-2 activation and inhibition of TIMP-2 (zeige TIMP2 Proteine) expression by NF-kappaB (zeige NFKB1 Proteine)-MT1-MMP (zeige MMP14 Proteine)-dependent and -independent pathway.
calcium-dependent phosphorylation of argininosuccinate synthase (zeige ASS1 Proteine) Ser (zeige SIGLEC1 Proteine)-328 is mediated by PKCalpha
VDAC phosphorylation is an important determinant of its interaction with dimeric tubulin (zeige TUBB Proteine).
Using yeast cells co-expressing the human wild-type p53 and a single mammalian PKCalpha, delta, epsilon or zeta, results showed a differential regulation of p53-mediated apoptosis by these PKC isoforms.
degradation of protein kinase C(alpha)in sperm capacitation is mediated by PRKA
Data suggest that ceramide interacts with the calcium-dependent lipid binding C2 domain of protein kinase C alpha and thereby induces translocation of the enzyme to the Golgi compartment.
analysis of amino acid critical for the catalytic competence and function of protein kinase (zeige CDK7 Proteine) Calpha (zeige PRKACA Proteine)
By regulating VEGFR2 (zeige KDR Proteine) expression and activation, PKC-epsilon (zeige PRKCE Proteine) expression is critical for activation of Akt (zeige AKT1 Proteine) and eNOS (zeige NOS3 Proteine) by VEGF (zeige VEGFA Proteine) and contributes to VEGF (zeige VEGFA Proteine)-stimulated Erk (zeige MAPK1 Proteine) activation, whereas PKC-alpha has opposite effects.
We conclude that ouabain, even at low concentrations (0.5-8.0 mum), can increase INaL and reverse INCX , and these effects may contribute to the effect of the glycoside to increase Ca(2 (zeige CA2 Proteine)+) transients and contractility.
These results suggest a complex antagonistic interplay between G(q)-activated PKC and Gbetagamma in regulation of L-VDCC, in which multiple cytosolic segments of alpha(1C) are involved.
Protein kinase C alpha (PKCalpha) regulates growth and invasion of endometrial cancer cells.
This study examined the protein expression and spatial-temporal distribution of PKCalpha and CPI-17 (zeige PPP1R14A Proteine) in intact smooth muscle tissues.
Results suggest that the action of genistein on protein kinase A is mediated via adenylate cyclase, but does not appear to involve Gs protein or ICI 182780-sensitive estrogen receptor (zeige ESR1 Proteine).
The PKCalpha, PKCbeta1, and PKCbeta2 mRNA levels tended to be lower in ischemia-reperfused than in sham-operated eyes in both the retinal arteries and the neuroretina.
protein level of retinal PKC-alpha is increased with maturation
Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role in cells. The protein encoded by this gene is one of the PKC family members. This kinase has been reported to play roles in many different cellular processes, such as cell adhesion, cell transformation, cell cycle checkpoint, and cell volume control. Knockout studies in mice suggest that this kinase may be a fundamental regulator of cardiac contractility and Ca(2+) handling in myocytes.
, protein kinase C alpha type
, protein kinase C, alpha
, protein kinase C alpha type-like
, aging-associated gene 6
, protein kinase c-alpha
, protein kinase, C alpha
, protein kinase C alpha