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ICAP-1 monoubiquitylation helps in switching from ROCK2 (zeige ROCK2 Proteine)-mediated to MRCKalpha-mediated cell contractility.
nuclear-cytoplasmic shuttling of ICAP1 influences both integrin activation and KRIT1 (zeige KRIT1 Proteine) localization, presumably impacting nuclear functions of KRIT1 (zeige KRIT1 Proteine).
The cocrystal structure of ICAP1 in complex with krev (zeige RAP1B Proteine) interaction trapped protein (KRIT)1 (zeige KRIT1 Proteine) is characterized here.
The structural basis for KRIT1 (zeige KRIT1 Proteine) antagonized ICAP1-modulated integrin-beta1 activation.
Annexin A1 (zeige ANXA1 Proteine) is associated with gastric cancer survival and promotes gastric cancer cell invasiveness through the formyl peptide receptor/extracellular signal-regulated kinase/integrin beta-1-binding protein 1 pathway.
Identify ICAP1 as a novel regulator to prevent excessive sprouting angiogenesis.
Site-directed mutagenesis showed that Leu(135), Ile(138), and Ile(139) of Icap1 alpha, and Leu(82) and Tyr (zeige TYR Proteine)(144), are required for the Icap1 alpha-beta(1) integrin interaction
Integrin-binding protein also interacts with Krit 1 (zeige KRIT1 Proteine) protein, cause of CCM1 (zeige KRIT1 Proteine). (ICAP-1, integrin cytoplasmic domain-associated protein 1)
beta(1) integrin viability signal in collagen matrices is transduced by focal adhesion kinase
ICAP-1 shuttles between the nucleus and cytoplasm in a beta1 integrin-dependent manner
The CCM1 (zeige KRIT1 Proteine) loss resulted in ICAP-1 destabilization, which increased beta1 integrin activation and led to increased RhoA (zeige RHOA Proteine)-dependent contractility.
Data show that phosphorylation of ICAP-1alpha by CaMKII (zeige CAMK2G Proteine) controls beta1 integrin activation and cell adhesion.
The ICAP-1 works in concert with kindlin-2 (zeige FERMT2 Proteine) to control the dynamics of beta1 integrin-containing fibrillar adhesions and, thereby, regulates fibronectin (zeige FN1 Proteine) deposition and osteoblast mineralization.
Live cell imaging, which was performed in both Icap-1-deficient mouse embryonic fibroblasts and cells expressing active beta(1) integrin, shows that the integrin high affinity state favored by talin is antagonistically controlled by ICAP-1.
ICAP-1 regulates beta1 integrin-dependent cell migration by affecting the pattern of focal adhesion formation.
Integrin cytoplasmic domain-associated protein-1 (ICAP-1) binds ROCK to beta1 integrin at the cell membrane (ICAP-1)
ICAP-1 promotes differentiation of osteoprogenitors by supporting their condensation through modulating the integrin high affinity state.
The cytoplasmic domains of integrins are essential for cell adhesion. The protein encoded by this gene binds to the beta1 integrin cytoplasmic domain. The interaction between this protein and beta1 integrin is highly specific. Two isoforms of this protein are derived from alternatively spliced transcripts. The shorter form of this protein does not interact with the beta1 integrin cytoplasmic domain. The longer form is a phosphoprotein and the extent of its phosphorylation is regulated by the cell-matrix interaction, suggesting an important role of this protein during integrin-dependent cell adhesion.
integrin beta-1-binding protein 1
, integrin cytoplasmic domain-associated protein 1
, integrin cytoplasmic domain-associated protein 1-alpha
, integrin cytoplasmic domain-associated protein 1-beta