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study evaluated the time-course of HO-1 and catalase (zeige CAT Proteine) gene expressions in nodules and roots of soybean plants subjected to cadmium treatment
Data suggest expression of hsp32 is up-regulated in kidney epithelial cells upon in vitro exposure to heavy metal water pollutants (Cd, As) or proteasomal inhibitors (MG132, withaferin A, celastrol); heat shock may be synergistic factor.
this study provides a better understanding of the role of the HO-1/Carbon monoxide system in controlling heart function in lower vertebrates.
The induced expression of HO-1 by fenofibrate appeared to be essential for mediating the protective effects of fenofibrate, as the inhibition of HO-1 activity significantly diminished the protective effects of fenofibrate against the GM-mediated death of sensory hair cells in cochlea
Suggest that Gata-1 (zeige GATA1 Proteine) and Nrf2a (zeige NFE2L2 Proteine) play differential roles in regulating the heme degradation enzymes hmox1a/bvra (zeige BLVRA Proteine)/bvrb (zeige BLVRB Proteine) during an early developmental period of heightened cellular stress.
Bach1 (zeige BACH1 Proteine) regulates the liver specificity and transience of the Nrf2a (zeige NFE2L2 Proteine)-dependent induction of hmox1a and that heme mediates this regulation through Bach1 (zeige BACH1 Proteine) inhibition based on its level in each tissue.
Data indicate that Heme oxygenase 1 (HY1) functioned negatively and acted upstream of ABSCISIC ACID-INSENSITIVE4 (ABI4) in drought signaling.
HY1 confers cadmium tolerance by decreasing nitric oxide production and improving iron homeostasis.
Data indicate that AtHO1 (HY1; heme oxygenase-1)-overexpressing plants generated more NO, whereas knock-down of AtHO1 expression reduced the level of nitric oxide (NO) in plants.
HY1 mutant exhibited progressive salt hypersensitivity.
Disrupting the binding of the AtHBP5 to haem oxygenase 1 (HY1) leads to oxidative stress.
Mutation of HY1 causes UV-C hypersensitivity by impairing carotenoid and flavonoid biosynthesis and the down-regulation of antioxidant defence.
HY1 and HY5 additively regulate the expression of light regulated genes and accumulation of chlorophyll and anthocyanin during early seedling development.
HY1 (Heme oxygenase 1) plays an important role in salt acclimation.
all members of the HO1 subfamily (HY1, HO3 and HO4) are active monomeric HOs and can convert haem to BV IXalpha using spinach Fd (ferredoxin) as an electron donor
HO2 (zeige HMOX2 Proteine) has an activity high enough to substitute for HO1 under aerobic conditions.
These results indicate that TNFRI (zeige TNFRSF1A Proteine)-Fc and hHO-1 overexpression may apparently induce free iron in the liver and exert oxidative stress by enhancing reactive oxygen species production and block normal postneonatal liver metabolism.
Mice overexpressing human HO-1 specifically in astrocytes are protected from collagenase-induced intracerebral hemorrhage, as examined by striatal cell viability, neurological deficits and mortality.
HMOX1 negatively regulates MMP-9 (zeige MMP9 Proteine) expression in chronic lymphocytic leukemia cells in response to arsenic trioxide, through modulation of the p38 MAPK (zeige MAPK14 Proteine)/AP-1 (zeige FOSB Proteine) signaling pathway.
Review/Meta-analysis: both the HO-1(GT)n repeat length polymorphism and the T(-413)A SNP are associated with decreased risk of coronary heart disease. The (GT)n repeat length polymorphism was associated with coronary restenosis following PCI (zeige SERPINA5 Proteine).
These data suggest that heme oxygenase-1 is induced during acute HIV-1 infection, likely mediating anti-inflammatory effects and driving expansion of heme oxygenase-1-specific CD8 (zeige CD8A Proteine) regulatory T cells capable of suppressing HIV-1-specific immune responses in vitro.
Among myelodysplastic syndromes patients only, CD163 (zeige CD163 Proteine) + macrophage density and HO1 and H-ferritin expression by CD163 (zeige CD163 Proteine) + macrophages increased in tandem with marrow iron. High HO1 was significantly associated with shorter overall survival.
elevated HMOX1 expression is associated with stemness in Glioblastoma multiforme and can be modulated through TGFbeta (zeige TGFB1 Proteine).
Fetal GTn (zeige GNAT3 Proteine) Repeat in the Heme Oxygenase 1 Promoter Is Associated With Severe and Early-Onset Preeclampsia.
CAL (zeige FBLIM1 Proteine) suppresses the expression of pro-inflammatory cytokines via p62 (zeige GTF2H1 Proteine)/Nrf2 (zeige GABPA Proteine)-linked HO-1 induction in RASFs.
Findings indicate the importance of nuclear heme oxygenase-1 (HO-1) post-translational modification in the induction of cancer progression.
These results provide a unique insight into the molecular mechanisms underlying the antiviral effects of the stress-responsive protein HO-1 during Porcine reproductive and respiratory syndrome virus infection.
findings collectively suggest that miR (zeige MYLIP Proteine)-506 acts as a tumor suppressor via regulation of ROCK1 (zeige ROCK1 Proteine) expression and may thus be a promising therapeutic target for HCC (zeige FAM126A Proteine)
Exogenous administration of CO exacerbated allergic symptoms, resulting in higher levels of both CO and heme oxygenase-1 expression, and a further reduction in H2S levels and CSE expression.
Down-regulation of HO-1 is associated with pulmonary arterial hypertension and right ventricular failure.
The study revealed the involvement of HO-1 in classical swine fever virus proliferation.
The protective properties of flavonoids, such as EGCG, against endothelial inflammation may be regulated in part though induction of HO-1 and subsequent activator protein-1 signaling.
Glutamate (zeige GRIN2C Proteine) regulates Ca2 (zeige CA2 Proteine)+ signals in smooth muscle cells of newborn piglet brain slice arterioles through astrocyte- and heme oxygenase-dependent mechanisms.
obalt protoporphyrin prevents postictal cerebral vascular dysfunction by upregulating HO-1.
Data demonstrate that lipopolysaccharides evoke a heat shock response, with an increase heat shock proteins 70 and Hsp32) and of VEGF (zeige VEGFA Proteine), a specific endothelial cell growth factor (zeige FGF1 Proteine).
Interaction of soluble factors in plasma possibly generated during PICSO are not responsible for upregulation of HO-1 and VEGF mRNA.
the data were consistent with HO-1 acting as an anti-viral factor and these findings suggested that induction of HO-1 may be a useful prevention and treatment strategy against BVDV infection.
These findings suggest that bronchiolar epithelial cells and macrophages up-regulate Nrf2 (zeige NFE2L2 Proteine) expression early in the course of infection, which results in increased expression of HO-1 within these cells.
investigation of molecular mechanisms of microvascular complications in diabetes/hyperglycemia: regulation of HO-1 gene expression in aortic endothelial cells by advanced glycation end products
Sickle blood increases endothelial heme oxygenase activity.
data provide evidence for the involvement of the thioredoxin/thioredoxin (zeige TXN Proteine) receptor system, in the regulation of haem oxygenase-1 expression in aortic endothelial cells during pro-oxidant challenge
Heme oxygenase-1 induction modulates hypoxic pulmonary vasoconstriction through upregulation of ecSOD/SOD3 (zeige SOD3 Proteine).
report that TLR signaling involving MyoD88 has a negative role in egress of HSPCs from BM into PB as TLR signaling enhances expression of HO-1 in hematopoietic cells
These findings indicate that the HO-1/EBP (zeige EBP Proteine) interaction plays a protective role in alleviating the dysfunction of oxidative stress and cardiac systolic function induced by cholesterol stimulation.
Taken together, these findings suggest that 2,3,5,4'-Tetrahydroxystilbene-2-O-beta-D-glucoside (TSG (zeige TWSG1 Proteine)) enhances mitochondrial biogenesis and function mainly via activation the HO-1. TSG (zeige TWSG1 Proteine) can be developed as a potential drug for treatment of inflammatory diseases.
The in vitro study illustrated that the anti-inflammatory effects of RA-XII were partially reversed following Nrf2 (zeige NFE2L2 Proteine) and HO-1 inhibition. Together, these findings strongly suggested that RA-XII is a potential agent against acute kidney injury.
mRNA and protein levels of heme oxygenase-1 (HO-1)aresignificantly increased by Melaleuca alternifolia oil via p38 (zeige CRK Proteine) and JNK (zeige MAPK8 Proteine) MAPK (zeige MAPK1 Proteine) activation.
Together with results showing involvement of TTF-1 (zeige NKX2-1 Proteine) in the TNF-alpha (zeige TNF Proteine)-induced increase in interleukin 1 beta (zeige IL1B Proteine) and monocyte chemotactic protein 1 (zeige CCL2 Proteine) production, this study suggests that TTF-1 (zeige NKX2-1 Proteine) plays an important role in the mouse hypothalamus TNF-alpha (zeige TNF Proteine)-induced inflammatory response for regulating HO-1 gene expression.
Curtailment of glial HO-1 transduction at strategic points of the life course may confer neuroprotection in human degenerative and developmental central nervous system disorders.
Results indicate the essential roles of heme oxygenase-1 (HO-1) in suppressing the pathogenesis of abdominal aortic aneurysm (AAA (zeige AAAS Proteine)), suggesting targeting HO-1 might be a promising therapeutic strategy for AAA (zeige AAAS Proteine).
inadequate HO-1 in striatal astrocytes might contribute to the limited antioxidant defense and dopaminergic neuron degeneration in PD, and preferential HO-1 activation in striatal astrocytes might be neuroprotective.
results indicate that high expression of HO-1 may reduce the severity of acute graft-versus-host disease by regulation of the TH17/Treg balance
The expression of oxidative stress markers were upregulated after light exposure but attenuated by cyanidin-3-glucoside and ferulic acid, which may be attributed to the elevated secretion and expression of heme oxygenase (HO-1) and nuclear factor erythroid-2 related factor 2 (Nrf2 (zeige NFE2L2 Proteine)).
Kidneys from circulation-restricted fetuses showed reduced heme oxygenase-1 mRNA.
Ligustrazine injection possesses notable protective effects on ischemia/reperfusion injury in rabbits by increasing the expression of HO-1 in lung.
Results add new evidence for the importance of HO-1 in the genesis and development of atherosclerosis and provide several possible mechanisms underlying the anti-atherosclerosis effects of HO-1
the effect of HO-1 on the progression and stabilization of vulnerable plaques and the possible mechanism
Heme-L-lysinate could attenuate atherosclerotic progression through upregulating HO-1 and HSP70 (zeige HSP70 Proteine) expression and increasing CO production.
These results suggest that HO-1 is important in limiting in-stent stenosis and can be regarded as a new therapeutic target.
Statins showed anti-atherosclerotic effects mediated by HO-1/eNOS (zeige NOS3 Proteine), restoring the [NO]/[ONOO(-)] imbalance and reducing lipid peroxidation.
HO-1/CO system was activated and may be one of the protective signal pathway during pulmonary ischemia-reperfusion injury in rabbits.
HO-1 contributes to vascular repair by increasing circulating endothelial progenitor cells (EPCs) derived from the bone marrow.
Heme oxygenase, an essential enzyme in heme catabolism, cleaves heme to form biliverdin, which is subsequently converted to bilirubin by biliverdin reductase, and carbon monoxide, a putative neurotransmitter. Heme oxygenase activity is induced by its substrate heme and by various nonheme substances. Heme oxygenase occurs as 2 isozymes, an inducible heme oxygenase-1 and a constitutive heme oxygenase-2. HMOX1 and HMOX2 belong to the heme oxygenase family.
heme oxygenase (decycling) 1
, heme oxygenase 1
, heme oxygenase
, Heme oxygenase
, heat shock protein, 32-kD
, heat shock protein 32
, heme oxygenase (decyclizing) 1
, P32 protein
, heme oxygenase-1