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anti-Human Cytochrome B Reductase 1 Antikörper:
anti-Mouse (Murine) Cytochrome B Reductase 1 Antikörper:
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Human Polyclonal Cytochrome B Reductase 1 Primary Antibody für IHC, ELISA - ABIN185343
Atanasova, Li, Bjarnason, Tzatchev, Simpson: Duodenal ascorbate and ferric reductase in human iron deficiency. in The American journal of clinical nutrition 2005
Show all 4 Pubmed References
Single nucleotide polymorphism in CYBRD1 gene is associated with hemochromatosis (zeige HFE Antikörper).
CYBRD1 has an involvement in iron homeostasis in chronic hepatitis C.
DCYTB is an important predictor of outcome and is associated with response to therapy in breast cancer patients.
Polymorphisms in CYBRD1 modulates iron phenotype in HFE (zeige HFE Antikörper) p.C282Y homozygous hemochromatosis (zeige HFE Antikörper).
Letter: report mutations in CYBRD1 promoter in and possible role in iron hemostasis in patients with porphyria cutanea tarda.
In Africans with iron overload not related to the HFE (zeige HFE Antikörper) gene, the possible involvement of the SLC40A1 (zeige SLC40A1 Antikörper) and CYBRD1 genes was demonstrated for the first time.
Duodenal cytochrome b present in human erythrocytes may contribute to their ability to reduce extracellular monodehydroascorbate.
Functional characterization of Cybrd1 heme groups and iron/ascorbate metabolism.
The results of this study confirm that Dcytb can act as a ferric reductase that stimulates iron uptake in Caco-2 cells.
It was concluded that Cybrd1 is the primary iron-regulated duodenal ferric reductase in the gut (zeige GUSB Antikörper) and that it is necessary for optimal iron metabolism.
Increased iron absorption reported in early hypoxia could be accounted for in part by the enhancement of Dcytb expression by Hif-2alpha (zeige EPAS1 Antikörper) in the duodenum.
Regulatory defects in liver and intestine implicate abnormal hepcidin (zeige HAMP Antikörper) and Cybrd1 expression in hemochromatosis (zeige HFE Antikörper).
Dcytb, DMT1 (zeige SLC11A2 Antikörper), Ireg1 (zeige SLC40A1 Antikörper) and transferrin receptor 1 (zeige TFR Antikörper) have roles in iron transport and hemolysis
Iron absorption genes(Dcytb,IREG1 (zeige SLC40A1 Antikörper),DMT1 (zeige SLC11A2 Antikörper))were expressed at lower levels in mouse caecum and colon than in the duodenum. They are regulated by body iron requirements.
loss of Cybrd1 had little or no impact on body iron stores, even in the setting of iron deficiency; other mechanisms must be available for the reduction of dietary iron
cybrd1 is nonessential in mice
Dcytb plays a physiological role in both iron and copper uptake, through divalent metal transporter 1 (DMT1 (zeige SLC11A2 Antikörper)) and copper transporter 1 (zeige SLC31A1 Antikörper), respectively.
This gene is a member of the cytochrome b(561) family that encodes an iron-regulated protein. It highly expressed in the duodenal brush border membrane. It has ferric reductase activity and is believed to play a physiological role in dietary iron absorption.
cytochrome b reductase 1
, cytochrome b561 family, member A2
, duodenal cytochrome b
, ferric-chelate reductase 3