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a new AHI-1 (zeige AHI1 ELISA Kits)-BCR-ABL (zeige ABL1 ELISA Kits)-DNM2 protein complex was uncovered, which regulates leukemic properties of these cells through a unique mechanism of cellular endocytosis and ROS (zeige ROS1 ELISA Kits)-mediated autophagy. Thus, targeting this complex may facilitate eradication of LSCs for curative therapies
dynamin-2, as a tetramer, might help to establish hemi-fusion and stabilizes the pore during HIV-1 fusion.
Data suggest DNM2/RRAGB (zeige RRAGB ELISA Kits)- (or DNM2/RRAGC (zeige RRAGC ELISA Kits)-)dependent endocytosis of extracellular amino acids (AAs (zeige FGD1 ELISA Kits)) plays critical role in mTORC1 transport/activation; recruitment of mTORC1 from cytoplasm to lysosome is suppressed by DNM2 inhibition; AA deprivation appears to be main cause of mTORC1 inactivation via DNM2 inhibition. (RHEB (zeige RHEB ELISA Kits) = Ras homolog enriched in brain (zeige RHEB ELISA Kits); DNM2 = dynamin II; RRAG = Ras-related GTP binding protein (zeige RAB10 ELISA Kits))
Study showed that dynamin 2 and cortactin participate in the formation of F-actin bundles, which stabilize filopodia in migrating cancer cells.
Data demonstrate that dynamin II is required for the E2:ERalpha (zeige ESR1 ELISA Kits) signaling of physiological functions and uncovers a role for autophagy in the control of ERalpha (zeige ESR1 ELISA Kits) turnover.
This study reported the clinical characteristics, molecular diagnosis strategy, and DNM2 gene mutations of four Chinese Han patients with centronuclear myopathy.
uncover a link between the dynamin 2 function and JNK (zeige MAPK8 ELISA Kits) signaling which leads to AP-1 (zeige FOSB ELISA Kits) induction
results provide evidence for a novel Arf6 (zeige ARF6 ELISA Kits) activation mechanism by Dyn2 through EFA6B and EFA6D in CME in a manner dependent upon the GTPase (zeige RACGAP1 ELISA Kits) activity of Dyn2
We conclude that DNM2 is a novel negative regulator of NO production in mouse collecting ducts.
In marked contrast to invadopodia, this degradation does not require the action of Src kinase (zeige CSK ELISA Kits), Cdc42 (zeige CDC42 ELISA Kits) or Dyn2. Rather, inhibition of Dyn2 causes a marked upregulation of stromal matrix degradation
Loss of Dynamin 2 GTPase (zeige RACGAP1 ELISA Kits) function results in microcytic anaemia.
DNM2 mutations cooperate with Lmo2 (zeige LMO2 ELISA Kits) T-cell oncogenes by enhancing IL-7 (zeige IL7 ELISA Kits) signalling.
Genetic disruption of Dyn2 GTPase (zeige RACGAP1 ELISA Kits) activity selectively in hepatic stellate cells enhances fibrogenesis.
Oxidative stress-induced (zeige SQSTM1 ELISA Kits) apoptosis and reactive oxygen species production are attenuated by not only Drp1 (zeige CRMP1 ELISA Kits) inhibition but also Dynamin 2 inhibition, implicating Dynamin 2 as a mediator of oxidative stress in cardiomyocytes.
Results show that centronuclear myopathy associated Dyn2 mutants are gain-of-function mutations, and their primary effect in muscle is T-tubule disorganization, which explains the susceptibility of muscle to Dyn2 hyperactivity.
Dynamin 2 might participate in the early embryonic development through an actin-based cytokinesis
Dynamin 2 has a role in endocytosis and in sustaining T-cell receptor signaling and driving metabolic reprogramming in T lymphocytes
DNM2-dependent endocytosis in megakaryocytes regulates megakaryopoiesis, thrombopoiesis, and bone marrow homeostasis.
Thus dynamin (zeige DNM1 ELISA Kits) that was recently found to control late stages of myoblast fusion also controls late stages of macrophage fusion, revealing an intriguing conserved mechanistic motif shared by diverse cell-cell fusion processes.
Using an inducible knockout mouse model to generate dynamin 1 (zeige DNM1 ELISA Kits)- and 2-deficient primary osteoclast precursors and myoblasts, it was shown that fusion of both cell types requires dynamin (zeige DNM1 ELISA Kits).
Dynamin-2 directs actin polymerization at the exocytosis site where both, in concert, adjust the hormone quantal release.
role of the proline-rich domain of dynamin-2 in in vitro potentiation of endothelial nitric-oxide synthase (zeige NOS3 ELISA Kits) activity.
Knocking down dynamin-2 by small interfering RNA reduced both leukotoxin internalization and cytotoxicity.
LKT-mediated cell death involve dynamin-2 and cyclophilin D
DNM2-S619L causes disease, in part, by interfering with membrane tubulation
Our findings suggest that dnm2 and dnm2-like are orthologs to human DNM2, and that they are required for normal zebrafish development.
Upregulation of miR (zeige MYLIP ELISA Kits)-124 expression corresponded to decreased expression of its target, DNM2, in the Japanese encephalitis virus -infected PK15 cells.
Dynamin 2 possibly regulates porcine oocyte maturation through its effects on actin-mediated spindle positioning and cytokinesis, and that this may depend on regulating ARP2 (zeige ACTR2 ELISA Kits) localization.
Dynamins represent one of the subfamilies of GTP-binding proteins. These proteins share considerable sequence similarity over the N-terminal portion of the molecule, which contains the GTPase domain. Dynamins are associated with microtubules. They have been implicated in cell processes such as endocytosis and cell motility, and in alterations of the membrane that accompany certain activities such as bone resorption by osteoclasts. Dynamins bind many proteins that bind actin and other cytoskeletal proteins. Dynamins can also self-assemble, a process that stimulates GTPase activity. Five alternatively spliced transcripts encoding different proteins have been described. Additional alternatively spliced transcripts may exist, but their full-length nature has not been determined.
, dynamin 2
, dynamin II