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we demonstrate that a pathological reduction in TNFAIP3 levels induced NF-kappaB (zeige NFKB1 Proteine)/SMAD7 (zeige SMAD7 Proteine) pathway activation, causing a deficiency in MSCs in ITP (zeige ITPA Proteine) patients. The ability of ITP (zeige ITPA Proteine)-MSCs to support megakaryocytic differentiation and thrombopoiesis of CD34 (zeige CD34 Proteine)(+) cells was impaired.
miR (zeige MLXIP Proteine)-125b regulates differentiation and reprogramming of T cell glucose metabolism via targeting A20 in T cell acute lymphoblastic leukemia.
Review/Meta-analysis: TNFAIP3 gene rs10499194, rs13207033 polymorphisms decrease the risk of rheumatoid arthritis, especially among Caucasian populations.
In vitro deletion of A20 in B cells compromised the expression of IL10.
Low A20 expression is associated with hepatocellular carcinoma.
The results suggest that TNFAIP3 polymorphisms (rs2230926, rs5029937, rs5029939, and rs3757173) are associated with susceptibility to systemic lupus erythematosus. (Meta-analysis)
Hepatitis C virus core protein ligates gC1qR (zeige C1QBP Proteine) to induce A20 expression in macrophages via P38 (zeige CRK Proteine), JNK (zeige MAPK8 Proteine) and NF-kappaB (zeige NFKB1 Proteine) signaling pathways, which leads to a low-grade chronic inflammation during HCV infection.
Results show that TNFAIP3 expression is regulated by miR (zeige MLXIP Proteine)-19b through targeting its 3'-UTR which contributes to the radioresistance of nasopharyngeal carcinoma and consequently activating the NF-kappaB (zeige NFKB1 Proteine) pathway.
demonstrates that TNFAIP3 gene polymorphisms (rs2230926 and rs5029937) are associated with the increased risk of rheumatoid arthritis. [META-ANALYSIS]
CHN1 and TNFAIP3 are candidate biomarkers for esophageal squamous cell carcinomas
Mice with A20 deficient B cells are prone to food allergy.
Tnfaip3, an anti-inflammatory gene, is located precisely underneath the linkage peak and contains two non-synonymous SNPs leading to conservative amino acid substitutions.
These results suggest that Leishmania exploits A20 and UCP2 (zeige UCP2 Proteine) to impair inflammasome activation for disease propagation
A20 promotes metastasis of aggressive basal-like breast cancers through multi-monoubiquitylation of Snail1 (zeige SNAI1 Proteine).
holding thymic production of natural Treg cells in check, A20 integrates Treg cell activity and increased effector T cell survival into an efficient CD4 (zeige CD4 Proteine)(+) T cell response
these studies establish A20 as a crucial hepatoprotective factor.
These results suggested that A20 is involved in regulating intracerebral hemorrhage-induced inflammatory injury in both the central and peripheral system
the ubiquitin-modifying enzyme TNFAIP3/A20, an upstream regulator of T cell receptor (TCR) signaling in T cells, is an essential cell-intrinsic regulator of Natural killer T differentiation.
these data reveal a crucial role of A20 in regulating the immunomodulatory activities of mesenchymal stem cells.
Data show the characterization and deduced amino acid sequence analysis for A20 gene which expression increases in MDBK cells infected by BVDV-1. Also, regulatory regions for NF-kappaB (zeige NFKB1 Proteine) and Sp-1 (zeige SP1 Proteine) additionally to an ARE element for mRNA stability were detected
This gene was identified as a gene whose expression is rapidly induced by the tumor necrosis factor (TNF). The protein encoded by this gene is a zinc finger protein and ubiqitin-editing enzyme, and has been shown to inhibit NF-kappa B activation as well as TNF-mediated apoptosis. The encoded protein, which has both ubiquitin ligase and deubiquitinase activities, is involved in the cytokine-mediated immune and inflammatory responses. Several transcript variants encoding the same protein have been found for this gene.
tumor necrosis factor, alpha-induced protein 3
, OTU domain-containing protein 7C
, TNF alpha-induced protein 3
, putative DNA-binding protein A20
, tumor necrosis factor alpha-induced protein 3
, tumor necrosis factor inducible protein A20
, zinc finger protein A20
, tumor necrosis factor induced protein 3