anti-Maus Interferon Regulatory Factor 3 Antikörper für Immunofluorescence (Paraffin-embedded Sections)

Recommended Interferon Regulatory Factor 3 Antibody (geliefert von: Anmelden zum Anzeigen )

Antigen
Interferon Regulatory Factor 3 (IRF3) Antikörper
  • irf3
  • IRF3
  • C920001K05Rik
  • IRF-3
  • interferon regulatory factor 3
  • interferon regulatory factor 7
  • irf3
  • IRF3
  • irf-3
  • Irf3
  • IRF7
Epitop
AA 375-425, pSer396
25
25
20
19
19
18
17
15
14
11
9
5
4
4
4
4
4
4
3
3
3
3
3
3
3
3
3
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
Reaktivität
Human, Maus, Ratte (Rattus)
310
120
68
6
6
6
3
2
2
1
1
1
1
Wirt
Kaninchen
254
86
3
Klonalität
Polyklonal
Konjugat
Unkonjugiert
7
6
6
5
4
4
4
4
4
4
3
3
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
Applikation
Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
281
134
99
75
50
45
41
31
26
14
13
8
4
3
3
2
2
1
1
Optionen
Hersteller
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Bilder

Produktnummer ABIN742688
$ 340.45
Zzgl. Versandkosten $45.00
Relevance Score ABIN Application Konjugat Host Isotype Epitope Hersteller Clonality References Details
1 ABIN682588 IF (p) IHC (p) WB Rabbit IgG AA 60-95 Anmelden zum Anzeigen Polyclonal 1
1 ABIN742695 IF (cc) IF (p) FITC Rabbit IgG AA 375-425, pSer396 Anmelden zum Anzeigen Polyclonal 1
1 ABIN903063 IF (p) Alexa Fluor 488 Rabbit IgG AA 60-95 Anmelden zum Anzeigen Polyclonal 0
1 ABIN903064 IF (p) Alexa Fluor 555 Rabbit IgG AA 60-95 Anmelden zum Anzeigen Polyclonal 0
1 ABIN903067 IF (p) Alexa Fluor 350 Rabbit IgG AA 60-95 Anmelden zum Anzeigen Polyclonal 0
1 ABIN903065 IF (p) Alexa Fluor 647 Rabbit IgG AA 60-95 Anmelden zum Anzeigen Polyclonal 0
1 ABIN742691 IF (cc) IF (p) Cy3 Rabbit IgG AA 375-425, pSer396 Anmelden zum Anzeigen Polyclonal 0
1 ABIN742692 IF (cc) IF (p) Cy5 Rabbit IgG AA 375-425, pSer396 Anmelden zum Anzeigen Polyclonal 0
1 ABIN742693 IF (cc) IF (p) Cy5.5 Rabbit IgG AA 375-425, pSer396 Anmelden zum Anzeigen Polyclonal 0
1 ABIN742694 IF (cc) IF (p) Cy7 Rabbit IgG AA 375-425, pSer396 Anmelden zum Anzeigen Polyclonal 0
1 ABIN682591 IF (p) Cy3 Rabbit IgG AA 60-95 Anmelden zum Anzeigen Polyclonal 0
1 ABIN682594 IF (p) Cy7 Rabbit IgG AA 60-95 Anmelden zum Anzeigen Polyclonal 0
1 ABIN682595 IF (p) FITC Rabbit IgG AA 60-95 Anmelden zum Anzeigen Polyclonal 0
1 ABIN682592 IF (p) Cy5 Rabbit IgG AA 60-95 Anmelden zum Anzeigen Polyclonal 0
1 ABIN682593 IF (p) Cy5.5 Rabbit IgG AA 60-95 Anmelden zum Anzeigen Polyclonal 0
1 ABIN875981 IF (cc) IF (p) Alexa Fluor 488 Rabbit IgG AA 375-425, pSer396 Anmelden zum Anzeigen Polyclonal 0
1 ABIN875979 IF (cc) IF (p) Alexa Fluor 647 Rabbit IgG AA 375-425, pSer396 Anmelden zum Anzeigen Polyclonal 0
1 ABIN875982 IF (cc) IF (p) Alexa Fluor 555 Rabbit IgG AA 375-425, pSer396 Anmelden zum Anzeigen Polyclonal 0
1 ABIN875980 IF (cc) IF (p) Alexa Fluor 350 Rabbit IgG AA 375-425, pSer396 Anmelden zum Anzeigen Polyclonal 0
1 ABIN2814916 IF (p) Alexa Fluor 594 Rabbit IgG AA 60-95 Anmelden zum Anzeigen Polyclonal 0

General

Antigen Interferon Regulatory Factor 3 (IRF3) Antikörper
Epitop AA 375-425, pSer396
(25), (25), (20), (19), (19), (18), (17), (15), (14), (11), (9), (5), (4), (4), (4), (4), (4), (4), (3), (3), (3), (3), (3), (3), (3), (3), (3), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reaktivität Human, Maus, Ratte (Rattus)
(310), (120), (68), (6), (6), (6), (3), (2), (2), (1), (1), (1), (1)
Wirt Kaninchen
(254), (86), (3)
Klonalität
Polyklonal
Konjugat Unkonjugiert
(7), (6), (6), (5), (4), (4), (4), (4), (4), (4), (3), (3), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1)
Applikation Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
(281), (134), (99), (75), (50), (45), (41), (31), (26), (14), (13), (8), (4), (3), (3), (2), (2), (1), (1)
Pubmed 4 Publikationen vorhanden
Hersteller Anmelden zum Anzeigen

Produktdetails

Antigendetails Anwendungsinformationen Handhabung Referenzen Bilder
Reinigung Purified by Protein A.
Immunogen KLH conjugated synthetic phosphopeptide derived from human IRF3 around the phosphorylation site of Ser396
Isotyp IgG

Antigendetails

Produktdetails Anwendungsinformationen Handhabung Referenzen Bilder zurück nach oben
Antigen
Andere Bezeichnung Irf3 (IRF3 Antibody Abstract)
Hintergrund

Key transcriptional regulator of type I interferon (IFN)-dependent immune responses which plays a critical role in the innate immune response against DNA and RNA viruses. Regulates the transcription of type I IFN genes (IFN-alpha and IFN-beta) and IFN-stimulated genes (ISG) by binding to an interferon-stimulated response element (ISRE) in their promoters. Acts as a more potent activator of the IFN-beta (IFNB) gene than the IFN-alpha (IFNA) gene and plays a critical role in both the early and late phases of the IFNA/B gene induction. Found in an inactive form in the cytoplasm of uninfected cells and following viral infection, double-stranded RNA (dsRNA), or toll-like receptor (TLR) signaling, is phosphorylated by IKBKE and TBK1 kinases. This induces a conformational change, leading to its dimerization and nuclear localization and association with CREB binding protein (CREBBP) to form dsRNA-activated factor 1 (DRAF1), a complex which activates the transcription of the type I IFN and ISG genes. Can activate distinct gene expression programs in macrophages and can induce significant apoptosis in primary macrophages.

Subcellular location: Cytoplasm, Nucleus

Synonyms: Interferon regulatory factor 3, IRF-3, IRF3

Gen-ID 3661
UniProt Q14653
Pathways TLR Signalweg, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Hepatitis C, Toll-Like Receptors Cascades

Anwendungsinformationen

Produktdetails Antigendetails Handhabung Referenzen Bilder zurück nach oben
Applikations-hinweise WB 1:100-1000
IHC-P 1:100-500
IF(IHC-P) 1:50-200
IF(ICC) 1:50-200
Beschränkungen Nur für Forschungszwecke einsetzbar

Handhabung

Produktdetails Antigendetails Anwendungsinformationen Referenzen Bilder zurück nach oben
Format Liquid
Konzentration 1 μg/μL
Buffer Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % sodium azide.
Konservierungs-mittel Sodium azide
Vorsichtsmaßnahmen This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
Lagerung -20 °C
Informationen zur Lagerung Store at -20°C
Haltbarkeit 12 months

Referenzen

Produktdetails Antigendetails Anwendungsinformationen Handhabung Bilder zurück nach oben
Produkt verwendet in:

Ando, Matsumoto, Taguchi, Kobayashi: "Poly (I:C) impairs NO donor-induced relaxation by overexposure to NO via the NF-kappa B/iNOS pathway in rat superior mesenteric arteries." in: Free radical biology & medicine, Vol. 112, pp. 553-566, 2017 Von den Autoren verwendete Methode: Western Blotting (WB) (Probematerial (Species): Rat (Rattus)). Weitere Details: Sample: arteries

Le Bel, Gosselin: "Leukotriene B4 Enhances NOD2-Dependent Innate Response against Influenza Virus Infection." in: PLoS ONE, Vol. 10, Issue 10, pp. e0139856, 2015 Von den Autoren verwendete Methode: Western Blotting (WB) (Probematerial (Species): Mouse (Murine)). Weitere Details: Sample: Lung

Ichikawa, Sugiura, Koarai, Minakata, Kikuchi, Morishita, Oka, Kanai, Kawabata, Hiramatsu, Akamatsu, Hirano, Nakanishi, Matsunaga, Yamamoto, Ichinose: "TLR3 activation augments matrix metalloproteinase production through reactive nitrogen species generation in human lung fibroblasts." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 192, Issue 11, pp. 4977-88, 2014

Menasria, Boivin, Lebel, Piret, Gosselin, Boivin: "Both TRIF and IPS-1 Adaptor Proteins Contribute to the Cerebral Innate Immune Response against Herpes Simplex Virus 1 Infection." in: Journal of virology, Vol. 87, Issue 13, pp. 7301-8, 2013

Bilder

Produktdetails Antigendetails Anwendungsinformationen Handhabung Referenzen zurück nach oben
Bilder des Herstellers
Immunohistochemistry (IHC) image for anti-Interferon Regulatory Factor 3 (IRF3) (AA 375-425), (pSer396) antibody (ABIN742688) Formalin-fixed and paraffin embedded mouse stomach tissue labeled with Anti-Phospho-I...
Immunofluorescence (IF) image for anti-Interferon Regulatory Factor 3 (IRF3) (AA 375-425), (pSer396) antibody (ABIN742688) Formalin-fixed and paraffin-embedded rat colitis labeled with Anti-Phospho-IRF3 (Ser3...
Western Blotting (WB) image for anti-Interferon Regulatory Factor 3 (IRF3) (AA 375-425), (pSer396) antibody (ABIN742688) Mouse liver lysates probed with Anti-IRF3 (Ser396) Polyclonal Antibody, Unconjugated ...
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) image for anti-Interferon Regulatory Factor 3 (IRF3) (AA 375-425), (pSer396) antibody (ABIN742688) Formalin-fixed and paraffin embedded mouse stomach tissue labeled with Anti-Phospho-I...
Western Blotting (WB) image for anti-Interferon Regulatory Factor 3 (IRF3) (AA 375-425), (pSer396) antibody (ABIN742688) U251 lysates probed with IRF3 (Ser396) Polyclonal Antibody, unconjugated at 1:300 ov...