anti-Human Interferon Regulatory Factor 3 Antikörper für Immunohistochemistry (Paraffin-embedded Sections)

Recommended Interferon Regulatory Factor 3 Antibody (geliefert von: Anmelden zum Anzeigen )

Antigen
Interferon Regulatory Factor 3 (IRF3) Antikörper
  • irf3
  • IRF3
  • C920001K05Rik
  • IRF-3
  • interferon regulatory factor 3
  • interferon regulatory factor 7
  • irf3
  • IRF3
  • irf-3
  • Irf3
  • IRF7
Epitop
AA 375-425, pSer396
26
21
19
19
19
17
15
14
12
11
9
5
4
4
4
4
4
4
3
3
3
3
3
3
3
3
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Reaktivität
Human, Maus, Ratte (Rattus)
290
122
71
7
6
6
3
2
2
1
1
1
1
Wirt
Kaninchen
257
63
3
Klonalität
Polyklonal
Konjugat
Unkonjugiert
7
6
6
4
4
3
3
3
3
2
2
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
Applikation
Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
267
129
103
77
50
41
28
26
25
14
13
8
4
3
3
2
2
1
Optionen
Hersteller
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Bilder

Produktnummer ABIN742688
$ 340.45
Zzgl. Versandkosten $45.00
Relevance Score ABIN Application Konjugat Host Isotype Epitope Hersteller Clonality References Details
11.414684 ABIN5946612 FACS ICC IF IHC IHC (p) WB Rabbit IgG Anmelden zum Anzeigen SD2062 0
11.414684 ABIN213923 IF IHC IHC (p) WB Rabbit IgG C-Term Anmelden zum Anzeigen Polyclonal 0
11.414684 ABIN214288 ICC IHC IHC (p) WB Rabbit IgG Internal Region Anmelden zum Anzeigen Polyclonal 0
11.414684 ABIN337252 IHC IHC (p) WB Rabbit IgG Anmelden zum Anzeigen Polyclonal 0
11.414684 ABIN4327554 ICC IF IHC IHC (p) WB Rabbit IgG Anmelden zum Anzeigen Polyclonal 0
11.414684 ABIN5557495 IF (cc) IHC (p) WB Rabbit IgG Anmelden zum Anzeigen 4C3 0
11.414684 ABIN4327551 ELISA ICC IF IHC IHC (p) WB Rabbit Anmelden zum Anzeigen Polyclonal 0
11.414684 ABIN4327550 ICC IF IHC IHC (p) WB Mouse IgG2a Anmelden zum Anzeigen 2G3 0
1 ABIN1498899 IF IHC IHC (p) WB Mouse IgG2a Anmelden zum Anzeigen 2G3 0
1 ABIN682588 IF (p) IHC (p) WB Rabbit IgG AA 60-95 Anmelden zum Anzeigen Polyclonal 1
1 ABIN5554904 EIA IHC (p) WB Rabbit IgG C-Term Anmelden zum Anzeigen Polyclonal 0
1 ABIN2610443 IHC IHC (p) IP WB Rabbit IgG AA 275-325 Anmelden zum Anzeigen Polyclonal 0
1 ABIN272027 IF IHC (p) WB Rabbit Anmelden zum Anzeigen Polyclonal 0
1 ABIN5956956 ELISA IHC (p) WB Rabbit IgG Ser396 Anmelden zum Anzeigen Polyclonal 0
1 ABIN5956957 ELISA IHC (p) WB Rabbit IgG Ser386 Anmelden zum Anzeigen Polyclonal 0
1 ABIN5956961 ELISA IF IHC (p) WB Rabbit IgG pSer385 Anmelden zum Anzeigen Polyclonal 0
1 ABIN303018 IF IHC (p) WB Rabbit Anmelden zum Anzeigen Polyclonal 0
1 ABIN302806 IHC (p) WB Rabbit Anmelden zum Anzeigen Polyclonal 0
1 ABIN1736027 IHC (p) WB Rabbit IgG Anmelden zum Anzeigen Polyclonal 0
1 ABIN5581052 ELISA IF IHC (p) WB Rabbit Anmelden zum Anzeigen Polyclonal 0

General

Antigen Interferon Regulatory Factor 3 (IRF3) Antikörper
Epitop AA 375-425, pSer396
(26), (21), (19), (19), (19), (17), (15), (14), (12), (11), (9), (5), (4), (4), (4), (4), (4), (4), (3), (3), (3), (3), (3), (3), (3), (3), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reaktivität Human, Maus, Ratte (Rattus)
(290), (122), (71), (7), (6), (6), (3), (2), (2), (1), (1), (1), (1)
Wirt Kaninchen
(257), (63), (3)
Klonalität
Polyklonal
Konjugat Unkonjugiert
(7), (6), (6), (4), (4), (3), (3), (3), (3), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1)
Applikation Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
(267), (129), (103), (77), (50), (41), (28), (26), (25), (14), (13), (8), (4), (3), (3), (2), (2), (1)
Pubmed 4 Publikationen vorhanden
Hersteller Anmelden zum Anzeigen

Produktdetails

Antigendetails Anwendungsinformationen Handhabung Referenzen Bilder
Reinigung Purified by Protein A.
Immunogen KLH conjugated synthetic phosphopeptide derived from human IRF3 around the phosphorylation site of Ser396
Isotyp IgG

Antigendetails

Produktdetails Anwendungsinformationen Handhabung Referenzen Bilder zurück nach oben
Antigen
Andere Bezeichnung Irf3 (IRF3 Antibody Abstract)
Hintergrund

Key transcriptional regulator of type I interferon (IFN)-dependent immune responses which plays a critical role in the innate immune response against DNA and RNA viruses. Regulates the transcription of type I IFN genes (IFN-alpha and IFN-beta) and IFN-stimulated genes (ISG) by binding to an interferon-stimulated response element (ISRE) in their promoters. Acts as a more potent activator of the IFN-beta (IFNB) gene than the IFN-alpha (IFNA) gene and plays a critical role in both the early and late phases of the IFNA/B gene induction. Found in an inactive form in the cytoplasm of uninfected cells and following viral infection, double-stranded RNA (dsRNA), or toll-like receptor (TLR) signaling, is phosphorylated by IKBKE and TBK1 kinases. This induces a conformational change, leading to its dimerization and nuclear localization and association with CREB binding protein (CREBBP) to form dsRNA-activated factor 1 (DRAF1), a complex which activates the transcription of the type I IFN and ISG genes. Can activate distinct gene expression programs in macrophages and can induce significant apoptosis in primary macrophages.

Subcellular location: Cytoplasm, Nucleus

Synonyms: Interferon regulatory factor 3, IRF-3, IRF3

Gen-ID 3661
UniProt Q14653
Pathways TLR Signalweg, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Hepatitis C, Toll-Like Receptors Cascades

Anwendungsinformationen

Produktdetails Antigendetails Handhabung Referenzen Bilder zurück nach oben
Applikations-hinweise WB 1:100-1000
IHC-P 1:100-500
IF(IHC-P) 1:50-200
IF(ICC) 1:50-200
Beschränkungen Nur für Forschungszwecke einsetzbar

Handhabung

Produktdetails Antigendetails Anwendungsinformationen Referenzen Bilder zurück nach oben
Format Liquid
Konzentration 1 μg/μL
Buffer Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % sodium azide.
Konservierungs-mittel Sodium azide
Vorsichtsmaßnahmen This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
Lagerung -20 °C
Informationen zur Lagerung Store at -20°C
Haltbarkeit 12 months

Referenzen

Produktdetails Antigendetails Anwendungsinformationen Handhabung Bilder zurück nach oben
Produkt verwendet in:

Ando, Matsumoto, Taguchi, Kobayashi: "Poly (I:C) impairs NO donor-induced relaxation by overexposure to NO via the NF-kappa B/iNOS pathway in rat superior mesenteric arteries." in: Free radical biology & medicine, Vol. 112, pp. 553-566, 2017 Von den Autoren verwendete Methode: Western Blotting (WB) (Probematerial (Species): Rat (Rattus)). Weitere Details: Sample: arteries

Le Bel, Gosselin: "Leukotriene B4 Enhances NOD2-Dependent Innate Response against Influenza Virus Infection." in: PLoS ONE, Vol. 10, Issue 10, pp. e0139856, 2015 Von den Autoren verwendete Methode: Western Blotting (WB) (Probematerial (Species): Mouse (Murine)). Weitere Details: Sample: Lung

Ichikawa, Sugiura, Koarai, Minakata, Kikuchi, Morishita, Oka, Kanai, Kawabata, Hiramatsu, Akamatsu, Hirano, Nakanishi, Matsunaga, Yamamoto, Ichinose: "TLR3 activation augments matrix metalloproteinase production through reactive nitrogen species generation in human lung fibroblasts." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 192, Issue 11, pp. 4977-88, 2014

Menasria, Boivin, Lebel, Piret, Gosselin, Boivin: "Both TRIF and IPS-1 Adaptor Proteins Contribute to the Cerebral Innate Immune Response against Herpes Simplex Virus 1 Infection." in: Journal of virology, Vol. 87, Issue 13, pp. 7301-8, 2013

Bilder

Produktdetails Antigendetails Anwendungsinformationen Handhabung Referenzen zurück nach oben
Bilder des Herstellers
Immunohistochemistry (IHC) image for anti-Interferon Regulatory Factor 3 (IRF3) (AA 375-425), (pSer396) antibody (ABIN742688) Formalin-fixed and paraffin embedded mouse stomach tissue labeled with Anti-Phospho-I...
Immunofluorescence (IF) image for anti-Interferon Regulatory Factor 3 (IRF3) (AA 375-425), (pSer396) antibody (ABIN742688) Formalin-fixed and paraffin-embedded rat colitis labeled with Anti-Phospho-IRF3 (Ser3...
Western Blotting (WB) image for anti-Interferon Regulatory Factor 3 (IRF3) (AA 375-425), (pSer396) antibody (ABIN742688) Mouse liver lysates probed with Anti-IRF3 (Ser396) Polyclonal Antibody, Unconjugated ...
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) image for anti-Interferon Regulatory Factor 3 (IRF3) (AA 375-425), (pSer396) antibody (ABIN742688) Formalin-fixed and paraffin embedded mouse stomach tissue labeled with Anti-Phospho-I...
Western Blotting (WB) image for anti-Interferon Regulatory Factor 3 (IRF3) (AA 375-425), (pSer396) antibody (ABIN742688) U251 lysates probed with IRF3 (Ser396) Polyclonal Antibody, unconjugated at 1:300 ov...