anti-Human Interferon Regulatory Factor 3 Antikörper für Enzyme Immunoassay

Recommended Interferon Regulatory Factor 3 Antibody (geliefert von: Anmelden zum Anzeigen )

Antigen
Interferon Regulatory Factor 3 (IRF3) Antikörper
  • irf3
  • IRF3
  • C920001K05Rik
  • IRF-3
  • interferon regulatory factor 3
  • interferon regulatory factor 7
  • irf3
  • IRF3
  • irf-3
  • Irf3
  • IRF7
Epitop
AA 108-166
27
24
19
19
18
18
17
15
15
11
9
5
4
4
4
4
4
4
3
3
3
3
3
3
3
3
3
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
Reaktivität
Human
301
122
72
7
6
6
3
2
2
1
1
1
1
1
Wirt
Maus
258
73
3
Klonalität
Monoklonal
Konjugat
Unkonjugiert
7
6
6
5
4
4
4
4
4
3
3
3
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
Applikation
Enzyme Immunoassay (EIA), Western Blotting (WB)
272
134
106
81
52
44
31
29
27
14
14
8
4
3
2
2
2
1
1
Hersteller
Anmelden zum Anzeigen
Hersteller Produkt- Nr.
Anmelden zum Anzeigen
Request

Produkt kostenlos erhalten?

Für Ihre Validierungsdaten erstatten wir Ihnen den vollen Kaufpreis. Ich möchte dieses Produkt validieren

Mehr erfahren

Bilder

Produktnummer ABIN317099
$ 522.50
Zzgl. Versandkosten $45.00
Relevance Score ABIN Application Konjugat Host Isotype Epitope Hersteller Clonality References Details
1 ABIN5554904 EIA IHC (p) WB Rabbit IgG C-Term Anmelden zum Anzeigen Polyclonal 0
1 ABIN5554905 EIA IF WB Rabbit IgG Intermediate Domain Anmelden zum Anzeigen Polyclonal 0

General

Antigen Interferon Regulatory Factor 3 (IRF3) Antikörper
Epitop AA 108-166
(27), (24), (19), (19), (18), (18), (17), (15), (15), (11), (9), (5), (4), (4), (4), (4), (4), (4), (3), (3), (3), (3), (3), (3), (3), (3), (3), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reaktivität Human
(301), (122), (72), (7), (6), (6), (3), (2), (2), (1), (1), (1), (1), (1)
Wirt Maus
(258), (73), (3)
Klonalität (Klon)
Monoklonal   ( )
Konjugat Unkonjugiert
(7), (6), (6), (5), (4), (4), (4), (4), (4), (3), (3), (3), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1)
Applikation Enzyme Immunoassay (EIA), Western Blotting (WB)
(272), (134), (106), (81), (52), (44), (31), (29), (27), (14), (14), (8), (4), (3), (2), (2), (2), (1), (1)
Pubmed 2 Publikationen vorhanden
Hersteller Anmelden zum Anzeigen

Produktdetails

Antigendetails Anwendungsinformationen Handhabung Referenzen Bilder
Spezifität The antibody recognizes human interferon regulatory factor 3 (IRF3), a 55 kDa constitutively expressed member of the IRF family. Other species not tested.
Produktmerkmale Synonyms: Interferon regulatory factor 3, IRF-3
Reinigung Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant
Immunogen Recombinant human IRF3 (108-166 aa) purified from E. coli
Klon 3F10
Isotyp IgG1

Antigendetails

Produktdetails Anwendungsinformationen Handhabung Referenzen Bilder zurück nach oben
Antigen
Andere Bezeichnung IRF3 (IRF3 Antibody Abstract)
Hintergrund Members of the Interferon regulatory factor (IRF) family regulate gene expression critical to immune response, hemopoiesis, and proliferation. IRF-3 is distinct from other family members. Its transcriptional activity is regulated solely by posttranslational modifications. It plays a crucial role in activation of innate immunity and inflammation in response to viral infection. IRF3 accumulates in an inactive form in the cytoplasm and then translocates to the nucleus as a homodimer, following stimuli-induced phosphorylation of specific serine/threonine residues. Association of the homodimer with p300/CBP (CREBB binding protein) forms dsRNA-activated factor 1 (DRAF1), which then activates the transcription of interferon alpha and beta, along with other interferon-induced genes.Synonyms: IRF-3, Interferon regulatory factor 3
Gen-ID 3661
UniProt Q14653
Pathways TLR Signalweg, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Hepatitis C, Toll-Like Receptors Cascades

Anwendungsinformationen

Produktdetails Antigendetails Handhabung Referenzen Bilder zurück nach oben
Applikations-hinweise ELISA. Western blot (1: 1,000 - 1: 3,000), recommended starting dilution is 1: 2,000.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Beschränkungen Nur für Forschungszwecke einsetzbar

Handhabung

Produktdetails Antigendetails Anwendungsinformationen Referenzen Bilder zurück nach oben
Format Liquid
Konzentration 1.0 mg/mL
Buffer PBS, pH 7.4, containing 10 % glycerol and 0.01 % sodium azide
Konservierungs-mittel Sodium azide
Vorsichtsmaßnahmen This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Lagerung 4 °C/-20 °C
Informationen zur Lagerung Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer. Avoid repeated freezing and thawing.
Shelf life: one year from despatch.
Haltbarkeit 12 months

Referenzen

Produktdetails Antigendetails Anwendungsinformationen Handhabung Bilder zurück nach oben
Allgemeine Veröffentlichungen

Pietilä, Veckman, Lehtonen, Lin, Hiscott, Julkunen: "Multiple NF-kappaB and IFN regulatory factor family transcription factors regulate CCL19 gene expression in human monocyte-derived dendritic cells." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 178, Issue 1, pp. 253-61, 2006

DeFilippis, Robinson, Keck, Hansen, Nelson, Früh: "Interferon regulatory factor 3 is necessary for induction of antiviral genes during human cytomegalovirus infection." in: Journal of virology, Vol. 80, Issue 2, pp. 1032-7, 2005

Bilder

Produktdetails Antigendetails Anwendungsinformationen Handhabung Referenzen zurück nach oben
Bilder des Herstellers
Western Blotting (WB) image for anti-Interferon Regulatory Factor 3 (IRF3) (AA 108-166) antibody (ABIN317099) anti-Interferon Regulatory Factor 3 (IRF3) (AA 108-166) antibody
Western Blotting (WB) image for anti-Interferon Regulatory Factor 3 (IRF3) (AA 108-166) antibody (ABIN317099) anti-Interferon Regulatory Factor 3 (IRF3) (AA 108-166) antibody (Image 2)