anti-Human CD36 Antikörper für Enzyme Immunoassay

Recommended CD36 Antibody (geliefert von: Anmelden zum Anzeigen )

Antigen
CD36 Molecule (thrombospondin Receptor) (CD36) Antikörper
  • BDPLT10
  • CHDS7
  • FAT
  • GP3B
  • GP4
  • GPIV
  • PASIV
  • SCARB3
  • Fat
  • Scarb3
  • GPIIIB
  • PAS-4
  • zgc:92513
  • CD36 molecule
  • CD36 molecule (thrombospondin receptor)
  • CD36
  • Cd36
  • cd36
Reaktivität
Human
360
153
93
8
7
4
4
3
3
3
1
Wirt
Maus
250
140
48
12
2
Klonalität
Monoklonal
Konjugat
Dieser CD36 Antikörper ist unkonjugiert
53
27
21
20
10
9
8
5
5
5
3
3
3
3
3
3
3
3
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
1
1
Applikation
Functional Studies (Func), Enzyme Immunoassay (EIA), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunofluorescence (IF), Western Blotting (WB)
288
145
130
91
66
41
39
39
37
25
14
3
3
3
3
3
2
2
2
2
2
1
1
1
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Produktnummer ABIN1106321
$ 423.50
Zzgl. Versandkosten $45.00
Relevance Score ABIN Application Konjugat Host Isotype Epitope Hersteller Clonality References Details
1 ABIN1106322 Func EIA IHC (fro) IF WB Biotin Mouse IgG1 Anmelden zum Anzeigen FA6-152 5
1 ABIN1106325 Func EIA IHC (fro) IF IP FITC Mouse IgG1 Anmelden zum Anzeigen FA6-152 5

General

Antigen CD36 Molecule (thrombospondin Receptor) (CD36) Antikörper
Reaktivität Human
(360), (153), (93), (8), (7), (4), (4), (3), (3), (3), (1)
Wirt Maus
(250), (140), (48), (12), (2)
Klonalität (Klon)
Monoklonal   ( )
Konjugat Dieser CD36 Antikörper ist unkonjugiert
(53), (27), (21), (20), (10), (9), (8), (5), (5), (5), (3), (3), (3), (3), (3), (3), (3), (3), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1)
Applikation Functional Studies (Func), Enzyme Immunoassay (EIA), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunofluorescence (IF), Western Blotting (WB)
(288), (145), (130), (91), (66), (41), (39), (39), (37), (25), (14), (3), (3), (3), (3), (3), (2), (2), (2), (2), (2), (1), (1), (1)
Pubmed 5 Publikationen vorhanden
Hersteller Anmelden zum Anzeigen

Produktdetails anti-CD36 Antikörper

Target Details CD36 Anwendungsinformationen Handhabung Referenzen für anti-CD36 Antikörper (ABIN1106321) Bilder
Spezifität This antibody recognizes human CD36 (88- kDa), a cell surface class B scavenger receptor, also known as thrombospondin receptor. It blocks the biological activity of CD36 by blocking collagen/thrombospondin binding. The antibody agglutinates fetal but not adult erythrocytes.
Kreuzreaktivität (Details) Species reactivity (tested):Human
Reinigung Protein G
Immunogen 20-Weeks-old fetal erythrocytes
Klon FA6-152
Isotyp IgG1
Plasmids, Primers & others

Target Details CD36

Produktdetails anti-CD36 Antikörper Anwendungsinformationen Handhabung Referenzen für anti-CD36 Antikörper (ABIN1106321) Bilder zurück nach oben
Antigen
Andere Bezeichnung CD36 (CD36 Antibody Abstract)
Hintergrund CD36 is a heavily N-glycosylated transmembrane protein of ~88 kDa with two short intracellular domains and a large extracellular domain. The protein is sensitive for neuroaminidase, resulting in a shift from 88 to 85 kDa. CD36 is expressed on platelets, mature monocytes and macrophages, microvascular endothelial cells, mammary endothelial cells, during stages of erythroid cell development and on some macrophage derived dendritic cells. The antibody recognizes adult and fetal monocytes, platelets and reticulocytes, but doesn't stain lymphocytes and granulocytes. Reactivity has also been found in small intestine, kidney, liver and thyroid. CD36 expression is primarily controlled by the transcription heterodimer PPARg-RXR (peroxisome proliferator-activated receptor-g-retinoid-X-receptor). CD36 is preferentially found within lipid rafts, which facilitates its association with receptors, signaling and adaptor molecules. It is a receptor and transporter of oxidized lipids and long chain fatty acids. CD36 has been implicated in many biological processes including angiogenesis, phagocytosis, inflammation, and lipid and glucose metabolism. Several in vivo models support the role of the thrombospondin / CD36 system in angiogenesis and tumor growth. An important role for CD36 has been found in Malaria as major receptor for P. falciparum-infected red blood cells. CD36 is associated with Src-family kinases and with the integrins α3β1 and α6β1. Recently, CD36 has been identified as a protein that is required for toll like receptor (TLR2) recognition of di-acylated bacterial lipopeptides and lipoteichoic acid4. Furthermore, CD36 has been shown to function as phagocytic receptor for apoptotic cells. Many different ligands have been reported to interact with CD36, suggesting that CD36 could recognize a structure-based domain rather than specific contact residues.Synonyms: Fatty acid translocase, GP3B, GP4, Glycoprotein IIIb, PAS IV, PAS-4, Platelet collagen receptor, Platelet glycoprotein 4, Platelet glycoprotein IV, Thrombospondin receptor
Gen-ID 948
NCBI Accession NP_000063
UniProt P16671
Pathways TLR Signalweg, Peptide Hormone Metabolism, Response to Growth Hormone Stimulus, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Regulation of Lipid Metabolism by PPARalpha, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Hepatitis C, Toll-Like Receptors Cascades, Lipid Metabolism

Anwendungsinformationen

Produktdetails anti-CD36 Antikörper Target Details CD36 Handhabung Referenzen für anti-CD36 Antikörper (ABIN1106321) Bilder zurück nach oben
Applikations-hinweise Optimal working dilution should be determined by the investigator.
Beschränkungen Nur für Forschungszwecke einsetzbar

Handhabung

Produktdetails anti-CD36 Antikörper Target Details CD36 Anwendungsinformationen Referenzen für anti-CD36 Antikörper (ABIN1106321) Bilder zurück nach oben
Konzentration 0.1 mg/mL
Buffer PBS, 0.1 % bovine serum albumin
Lagerung 4 °C
Informationen zur Lagerung Store at 2 - 8 °C.

Referenzen für anti-CD36 Antikörper (ABIN1106321)

Produktdetails anti-CD36 Antikörper Target Details CD36 Anwendungsinformationen Handhabung Bilder zurück nach oben
Allgemeine Veröffentlichungen

Ehara, Ueda, Naruko, Haze, Matsuo, Ogami, Ikura, Itabe, Komatsu, Yoshiyama, Takeuchi, Yoshikawa: "Pathophysiological role of oxidized low-density lipoprotein in plaque instability in coronary artery diseases." in: Journal of diabetes and its complications, Vol. 16, Issue 1, pp. 60-4, 2002

Nakata, Nakagawa, Nishida, Nozaki, Miyagawa, Nakagawa, Tamura, Matsumoto, Kameda-Takemura, Yamashita, Matsuzawa: "CD36, a novel receptor for oxidized low-density lipoproteins, is highly expressed on lipid-laden macrophages in human atherosclerotic aorta." in: Arteriosclerosis, thrombosis, and vascular biology, Vol. 19, Issue 5, pp. 1333-9, 1999

Thibert, Bellucci, Edelman, Tandon, Legrand: "Quantitation of platelet glycoprotein IV (CD36) in healthy subjects and in patients with essential thrombocythemia using an immunocapture assay." in: Thrombosis and haemostasis, Vol. 68, Issue 5, pp. 600-5, 1993

Kieffer, Bettaieb, Legrand, Coulombel, Vainchenker, Edelman, Breton-Gorius: "Developmentally regulated expression of a 78 kDa erythroblast membrane glycoprotein immunologically related to the platelet thrombospondin receptor." in: The Biochemical journal, Vol. 262, Issue 3, pp. 835-42, 1990

Edelman, Vinci, Villeval, Vainchenker, Henri, Miglierina, Rouger, Reviron, Breton-Gorius, Sureau: "A monoclonal antibody against an erythrocyte ontogenic antigen identifies fetal and adult erythroid progenitors." in: Blood, Vol. 67, Issue 1, pp. 56-63, 1986