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Mouse (Murine) GRP78 ELISA Kit für Sandwich ELISA - ABIN425546
Li, Zhu, Shen, Wan, Arnold, Peng: Deficiency of rac1 blocks NADPH oxidase activation, inhibits endoplasmic reticulum stress, and reduces myocardial remodeling in a mouse model of type 1 diabetes. in Diabetes 2010
In amphibians, the association of BiP with unfolded protein and its possible role in aggresome function may be vital in the maintenance of cellular proteostasis.
Hspa5 is essential for pronephros formation by mediating retinoic acid signaling.
Overexpression or knockdown demonstrated that GRP78 promoted proliferation and anti-apoptosis of clear cell renal cell carcinoma cells, and the oncogenic activity of GRP78 resulting in by miR (zeige MLXIP ELISA Kits)-30a-5p overexpression.
this study provided mechanistic evidences to support the positive regulatory function of FOXM1 (zeige FOXM1 ELISA Kits) in HSPA5 expression in colorectal cancer
Cancer-associated fibroblasts induced GRP78 expression in A549 and SPCA-1 (zeige ATP2C1 ELISA Kits) cells to facilitate Non-Small Cell Lung Cancer cell migration and invasion
results suggest that the cooperative effects of radiotherapy and cetuximab could be further improved by inhibiting GRP78 in non-responsive oropharyngeal carcinoma patients
Study reports that the endoplasmic reticulum luminal co-chaperone ERdj4/DNAJB9 (zeige DNAJB9 ELISA Kits) is a selective IRE1 (zeige ERN1 ELISA Kits) repressor that promotes a complex between the luminal Hsp70 (zeige HSP70 ELISA Kits) BiP (zeige GDF10 ELISA Kits) and the luminal stress-sensing domain of IRE1alpha (zeige ERN1 ELISA Kits).
GRP78 role in the resistance to cisplatin in the nasopharyngeal carcinoma cells.
High expression of GRP78 is associated with nonalcoholic steatohepatitis.
Data show that cancer-associated fibroblasts (CAFs (zeige TBX1 ELISA Kits))-derived hepatocyte growth factor (HGF (zeige HGF ELISA Kits)) or recombinant HGF (zeige HGF ELISA Kits) activated c-Met/phosphoinositide 3-kinase (PI3K (zeige PIK3CA ELISA Kits))/Akt (zeige AKT1 ELISA Kits) and glucose-regulated protein 78 (GRP78) signalling pathways in ovarian cancer cells.
HSPA5/BIP has roles in endoplasmic reticulum stress, autophagy and apoptosis; inhibitors of HSPA5 could be useful in cancer treatment
Immunohistochemical analysis showed that STAT3 (zeige STAT3 ELISA Kits), GRP78 and BAX (zeige BAX ELISA Kits) protein levels in the combination group were significantly higher than those in STAT3 (zeige STAT3 ELISA Kits) group and CDDP group (P<0.05). Exogenous STAT3 (zeige STAT3 ELISA Kits) and CDDP may synergistically inhibit the xenograft tumour growth through up-regulation of BAX (zeige BAX ELISA Kits) protein via GRP78.
This paper reports the localization of both GRP78 and HSP60 (zeige HSPD1 ELISA Kits) on the luminal/apical surface of oviduct epithelial cells, their binding to spermatozoa, and the presence of endogenous HSP60 (zeige HSPD1 ELISA Kits) in the sperm midpiece.
BiP is a master regulator of endoplasmic reticulum function, and its cleavage by subtilase cytotoxin represents a previously unknown trigger for cell death
Over-expression of GRP78 enhances replication of Porcine Circovirus 2.
These results indicate that GRP78, but not nutritional status, is a potent up-regulator of hepatic PTC (zeige PTCH1 ELISA Kits)-mRNA levels during induction of ER stress in vivo.
Data suggest that activation of GRP78/Ire1 (zeige ERN1 ELISA Kits)/Xbp1 (zeige XBP1 ELISA Kits) pathway of ER stress-unfolded protein response is involved in mouse decidualization.
Upregulating HSF1 (zeige HSF1 ELISA Kits) relieves the tau toxicity in N2a-TauRD DeltaK280 by reducing CHOP (zeige DDIT3 ELISA Kits) and increasing HSP70 (zeige HSP70 ELISA Kits) a5 (BiP/GRP78). Our work reveals how the bidirectional crosstalk between the two stress response systems promotes early tau pathology and identifies HSF1 (zeige HSF1 ELISA Kits) being one likely key player in both systems.
These results demonstrate a key role for GRP78 in alveolar epithelial cell survival.
These results indicate that GRP78, an endoplasmic reticulum chaperon of the HSP70 (zeige HSP70 ELISA Kits) family, is a novel host factor involved at multiple steps of the Japanese encephalitis virus life cycle and could be a potential therapeutic target.
Genetic or pharmacologic inhibition of the HSPA5-GPX4 pathway enhanced gemcitabine sensitivity by disinhibiting ferroptosis in vitro and in both subcutaneous and orthotopic animal models of PDAC.
The data presented indicate that the unfolded protein response is activated in fibrotic lung tissue and strongly localized to macrophages. GRP78- and CHOP (zeige DDIT3 ELISA Kits)-mediated macrophage apoptosis was found to protect against bleomycin-induced fibrosis.
Endoplasmic reticulum stress gene GRP78 is involved in signaling pathway during hepatitis B virus-mediated hepatocarcinogenesis.
data show that Med inhibits ER stress-induced apoptosis and promotes osteoblast cell survival by targeting GRP78.
These results suggested the important roles of endoplasmic reticulum-related chaperons, Bip and SIL1 (zeige SIL1 ELISA Kits), in Alzheimer's disease-like tau hyperphosphorylation.
Phosphatidylinositol deficient zebrafish have elevated hspa5 expression in the liver and hepatic lipid accumulation due to endoplasmic reticulum stress response.
The protein encoded by this gene is a member of the heat shock protein 70 (HSP70) family. It is localized in the lumen of the endoplasmic reticulum (ER), and is involved in the folding and assembly of proteins in the ER. As this protein interacts with many ER proteins, it may play a key role in monitoring protein transport through the cell.
78 kDa glucose-regulated protein
, heat shock 70 kDa protein 5
, Protein 1603
, 78 kDa glucose-regulated protein homolog
, luminal-binding protein
, glucose-regulated protein 78
, glucose-regulated protein 78kDa
, heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
, GRP 78
, heavy-chain binding protein BiP
, immunoglobulin heavy chain-binding protein
, endoplasmic reticulum lumenal Ca(2+)-binding protein grp78
, glucose-regulated protein, 78kDa
, XAP-1 antigen
, glucose regulated protein, 78 kDa
, heat shock 70kD protein 5 (glucose-regulated protein, 78kD)
, heat shock 70kD protein 5
, heat shock 70kDa protein 5 (glucose-regulated protein)
, steroidogenesis-activator polypeptide