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Human Asialoglycoprotein Receptor 1 Protein expressed in Human Cells - ABIN2215180
Christie, Simerská, Jen, Hussein, Rawi, Hartley-Tassell, Day, Jennings, Toth: A drug delivery strategy: binding enkephalin to asialoglycoprotein receptor by enzymatic galactosylation. in PLoS ONE 2014
Authors report the generation of a human embryonic stem cell line WAe001-A-6 harbouring homozygous ASGR1 mutations using CRISPR/Cas9. The mutation involves a 37bp deletion, resulting in a frame shift.
PEGylated lipoplexes were well tolerated by both HEK293 (ASGP (zeige MUC4 Proteine)-R-negative) and HepG2 (ASGP (zeige MUC4 Proteine)-R-positive) cell lines and delivered DNA to the hepatoma cell line HepG2 by ASGP (zeige MUC4 Proteine)-R mediation at levels three-fold greater than nonPEGylated lipoplexes.
findings show that the hepatitis E virus (HEV) ORF2 protein interacts directly with the ectodomain of both ASGR1 and ASGR2; ASGPR is involved in and facilitates HEV infection by binding to ORF2
ASGR1 can inhibit the activity of V-ATPase (zeige ATP6V1H Proteine) by interacting with LASS2 (zeige CERS2 Proteine), thereby suppressing the metastatic potential of hepatoma cells.
This review will focus on the mechanisms of platelet senescence with specific emphasis on the role of post-translational modifications in platelet life-span and thrombopoietin (zeige THPO Proteine) production downstream of the hepatic Ashwell-Morrell receptor, originally termed asialoglycoprotein receptor (ASGPR).
ASGR1 haploinsufficiency was associated with reduced levels of non-HDL (zeige HSD11B1 Proteine) cholesterol and a reduced risk of coronary artery disease.
Flow cytometric assessment of ASGPR expression may be a useful predictor of liver dysfunction following major hepatectomy for HCC (zeige FAM126A Proteine) in Chinese patients.
Anti-ASGPR antibody could be used for specific and efficient HCC (zeige FAM126A Proteine) CTC enrichment, and anti-P-CK combined with anti-CPS1 (zeige CPS1 Proteine) antibodies is superior to identification with one antibody alone in the sensitivity for HCC (zeige FAM126A Proteine) CTC detection.
Endocytic AMR (zeige GPR182 Proteine) controls TPO (zeige THPO Proteine) expression through Janus kinase 2 (JAK2 (zeige JAK2 Proteine)) and the acute phase response signal transducer and activator of transcription 3 (STAT3 (zeige STAT3 Proteine)) in vivo and in vitro
Anti-ASGPR levels correlate with biochemical parameters and with the severity and manifestation autoimmune processes in patients with autoimmune hepatitis.
the key roles of the ManR and ASGR in controlling circulating levels of numerous glycoproteins critical for regulating reproductive hormones and blood coagulation.
Mice lacking the hepatocyte asialoglycoprotein receptor are more susceptible to the induction of T cell-mediated hepatitis suggesting a potentially significant role of the ASGPR in the homeostatic regulation of T cells in the liver.
found that the asialoglycoprotein receptor (ASGPR) is involved in hepatocyte recognition of cells predestined for killing, including activated autologous T lymphocytes
Asialoglycoprotein receptor 1 is a novel important factor that responds to endogenous lectins in the tumor microenvironment to promote metastasis by activating the epidermal growth factor receptor (zeige EGFR Proteine)-extracellular signal-regulated kinase pathway.
The Ashwell receptor is composed of type 2 transmembrane glycoproteins termed Asgr1 and Asgr2 (zeige ASGR2 Proteine). Both are predominantly expressed in the liver.
Proper ASGP (zeige MUC4 Proteine) receptor function protects against carbon tetrachloride-induced liver damage in a knockout mouse model lacking functional ASGP (zeige MUC4 Proteine) receptor.
The ASGR1 expressed on aortic and limb arterial pig vascular endothelium plays a role in binding and phagocytosis of human platelets.
This gene encodes a subunit of the asialoglycoprotein receptor. This receptor is a transmembrane protein that plays a critical role in serum glycoprotein homeostasis by mediating the endocytosis and lysosomal degradation of glycoproteins with exposed terminal galactose or N-acetylgalactosamine residues. The asialoglycoprotein receptor may facilitate hepatic infection by multiple viruses including hepatitis B, and is also a target for liver-specific drug delivery. The asialoglycoprotein receptor is a hetero-oligomeric protein composed of major and minor subunits, which are encoded by different genes. The protein encoded by this gene is the more abundant major subunit. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
asialoglycoprotein receptor 1
, C-type lectin domain family 4 member H1
, hepatic lectin H1
, ASGP-R 1
, ASGPR 1
, hepatic lectin 1
, Asialoglycoprotein receptor 1 (hepatic lectin)
, asialoglycoprotein receptor (RHL1)
, hepatic lectin 1 RHL1
, hepatic lectin 1, RHL1