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Protein kinase C acts as a tumor suppressor.Cancer-associated mutations in protein kinase C are generally loss-of-function mutations.[review]
PKCvarepsilon directly modulates the Aurora B (zeige AURKB Proteine)-dependent abscission checkpoint by phosphorylating Aurora B (zeige AURKB Proteine) at S227. This phosphorylation invokes a switch in Aurora B (zeige AURKB Proteine) specificity, with increased phosphorylation of a subset of target substrates, including the CPC subunit Borealin (zeige CDCA8 Proteine).
Results indicate an important role of protein kinase C epsilon (PKCepsilon) in autophagy and as a therapeutic target.
PKC epsilon, activated by DCP (zeige ACE Proteine)-LA, increases elastin (zeige ELN Proteine) and fibulin-5 (zeige FBLN5 Proteine)/DANCE in the extracellular space of cultured fibroblasts by the mechanism independent of transcriptional and translational modulation or inhibition of elastolysis.
The downregulation of mi143 promoted cell proliferation by regulating PKCepsilon in the hepatocellular carcinoma cells.
These results demonstrate the relevance of hepatic diacylglycerol-induced PKCepsilon activation in the pathogenesis of NAFLD-associated hepatic insulin (zeige INS Proteine) resistance in humans.
Data show that protein kinase C epsilon (PKCepsilon) phosphorylates migration and invasion inhibitory protein (MIIP (zeige MIIP Proteine)) at Ser303 and promotes its binding to RelA/p65 (zeige NFkBP65 Proteine), facilitating colorectal cancer metastasis.
NF-kappaB (zeige NFKB1 Proteine) signaling thus appears to play a critical role in promoting both castration resistance and enzalutamide resistance in PKC (zeige PRRT2 Proteine)/Twist1 (zeige TWIST1 Proteine) signaling in prostate cancer.
results imply that an intimate correlation between miR (zeige MLXIP Proteine)-218-5p and PRKCE/MDR1 axis abnormal expression is a key determinant of gemcitabine tolerance, and suggest a novel miR (zeige MLXIP Proteine)-218-5p-based clinical intervention target for Gallbladder cancer patients.
Resistin (zeige RETN Proteine)-associated vascular smooth muscle cell dysfunction and intimal hyperplasia are related to PKCepsilon-dependent Nox activation and ROS (zeige ROS1 Proteine) generation
Data indicate that sirtuin 5 (SIRT5 (zeige SIRT5 Proteine)) is an important mitochondrial enzyme for protection against metabolic and ischemic stress following protein kinase C epsilon (PKCepsilon) activation in the brain.
abnormal PKC-epsilon/PKC-delta (zeige PKCd Proteine) ratio promotes the activation of Drp1 (zeige CRMP1 Proteine) signalling, caspase (zeige CASP3 Proteine) cascades and GSK-3beta-dependent mPTP (zeige PTPN2 Proteine) opening
PKCepsilon deletion in the epidermis resulted in inhibition of UVR-induced Stat3 (zeige STAT3 Proteine) phosphorylation.
PKCepsilon is a negative regulator of megakaryopoiesis
study establishes that the pseudosubstrate of PKC-epsilon binds phosphatidylinositol 4-phosphate (PI4P), tethering it to the trans-Golgi network (TGN (zeige TG Proteine)). This TGN (zeige TG Proteine)-associated pool of PKC-epsilon is necessary for its concentration at the phagocytic cup and Fc [gamma] receptor (FcgammaR)-dependent membrane fusion
that PKC-epsilon activation mediates 1) dysfunction of complexes I and III of the respiratory chain, 2) oxidant production, 3) morphological damage to the kidney, and 4) decreases in renal functions after ischemia
Sstudy provides evidence that PKCepsilon-ALDH2 (zeige ALDH2 Proteine) pathway positively regulates adipocyte differentiation by regulation of PPARgamma (zeige PPARG Proteine) transcriptional activity.
Data suggest that PKCe positively regulates beta-catenin (zeige CTNNB1 Proteine) expression and stabilization in a glycogen synthase kinase 3beta-independent manner; beta-catenin (zeige CTNNB1 Proteine) exhibits a perinuclear localization pattern in podocytes; however, beta-catenin (zeige CTNNB1 Proteine) is predominantly localized to nucleus in podocytes from PKCe knockout mice. (PKCe = protein kinase C epsilon)
Results demonstrate that specific inhibition of PKCepsilon reduces ethanol consumption and prolongs ethanol intoxication, support the development of inhibitors of PKCepsilon catalytic activity as a strategy to reduce ethanol consumption, and they demonstrate that the AS- PKCepsilon mouse is a useful tool to study the role of PKCepsilon in behavior.
These data identify PKCepsilon as a key regulator of cilia slowing in response to combined smoke and alcohol-induced lung injury.
deltaPKC inhibition or varepsilonPKC activation repairs endothelial vascular dysfunction by regulating eNOS (zeige NOS3 Proteine) post-translational modification
Differential expression of protein kinase C epsilon and an elevation of [Ca(2 (zeige CA2 Proteine)+)]i are important for acquisition of luteolytic response to PGF2 alpha
By regulating VEGFR2 (zeige KDR Proteine) expression and activation, PKC-epsilon expression is critical for activation of Akt (zeige AKT1 Proteine) and eNOS (zeige NOS3 Proteine) by VEGF (zeige VEGFA Proteine) and contributes to VEGF (zeige VEGFA Proteine)-stimulated Erk (zeige MAPK1 Proteine) activation, whereas PKC-alpha (zeige PKCa Proteine) has opposite effects.
Activation of PKC induces the translocation of Nrf2 (zeige NFE2L2 Proteine) and the enhancement of endogenous antioxidant defenses in ischemic preconditioned rabbit heart.
in contrast to protective effects of PKC-epsilon activation in cardiomyocytes, sustained PKC-epsilon activation is detrimental to mitochondrial function and viability in renal proximal tubule cells
Preferential glucose utilization by PKCepsilon hearts is orchestrated by a p-GSK3beta/HIF-1alpha (zeige HIF1A Proteine)-mediated mechanism.
Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role in cells. The protein encoded by this gene is one of the PKC family members. This kinase has been shown to be involved in many different cellular functions, such as neuron channel activation, apoptosis, cardioprotection from ischemia, heat shock response, as well as insulin exocytosis. Knockout studies in mice suggest that this kinase is important for lipopolysaccharide (LPS)-mediated signaling in activated macrophages and may also play a role in controlling anxiety-like behavior.
protein kinase C epsilon type
, protein kinase C, epsilon
, protein kinase C epsilon type-like
, pkc epsilon
, protein kinase C, eta