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blockage of RhoA (zeige RHOA Proteine)/ROCK repressed the TAK1 (zeige MAP3K7 Proteine)/NOD2-mediated NF-kappaB (zeige NFKB1 Proteine) pathway in HaCaT cells exposed to UVB.
Study found that TR4 might be able to function through activation of the AKT3 (zeige AKT3 Proteine) expression to drive the EMT (zeige ITK Proteine) phenotype and enhance the seminoma cell proliferation and invasion.
Altering TR4-ATF3 (zeige ATF3 Proteine) signaling increases the efficacy of cisplatin to suppress hepatocellular carcinoma growth/progression.
High TAK1 (zeige MAP3K7 Proteine) expression is associated with the progression of hepatocellular carcinoma.
Here, we report that Pseudomonas aeruginosa ExoY inhibits proinflammatory cytokine production through suppressing the activation of TAK1 (zeige MAP3K7 Proteine) as well as downstream NF-kappaB (zeige NFKB1 Proteine) and mitogen-activated protein (MAP) kinases.
SIRT7 inhibits TR4 degradation by deacetylation of DDB1.
TR4 binds GR to play an important role in glucocorticoid-directed corticotroph tumor POMC (zeige POMC Proteine) regulation in addition to modulating glucocorticoid actions on other GR targets.
this study shows that TAP1 (zeige TAP1 Proteine) plays a novel role in the negative regulation of virus-triggered NF-kappaB (zeige NFKB1 Proteine) signaling and the innate immune response by targeting the TAK1 (zeige MAP3K7 Proteine) complex
TAK1 (zeige MAP3K7 Proteine)/TAB1 (zeige TAB1 Proteine) expression in non-small cell lung carcinoma tissue is significantly increased and closely associated with patient clinical prognosis.
miR (zeige MLXIP Proteine)-203 represses NF-kappaB (zeige NFKB1 Proteine) signaling via targeting TAK1 (zeige MAP3K7 Proteine) and PI3KCA and miR (zeige MLXIP Proteine)-203 overexpression may contribute to the COPD (zeige ARCN1 Proteine) initiation.
TNFalpha (zeige TNF Proteine)-induced phosphorylation of RIPK1 (zeige RIPK1 Proteine) in the intermediate domain by TAK1 plays a key role in regulating the decision between three distinct mechanisms of cell death: necroptosis, RIPK1 (zeige RIPK1 Proteine)-independent and dependent apoptosis.
The results suggest that an intron-free Renilla luciferase reporter may provide a satisfactory internal control for TR4 at certain dose range. Findings advocate caution on the use of Renilla luciferase as an internal control in TR4-directed studies to avoid misleading data interpretation.
We conclude that TR4 is required for the normal differentiation and proliferation of erythroid cells, in addition to its previously characterized roles in embryonic and fetal globin gene repression
CNS-specific Tak1 deletion prevented ER-stress-induced hypothalamic leptin (zeige LEP Proteine) resistance and hyperphagic obesity under a high-fat diet (HFD). Thus, TAK1 is a crucial regulator of ER stress in vivo, which could be a target for alleviation of ER stress and its associated disease conditions.
this study shows that TAK1 negatively regulates lipopolysaccharide-induced cytokine secretion in myeloid cells by inhibiting MEKK3 (zeige MAP3K3 Proteine) activities
The present study demonstrates that TIPE2 (zeige TNFAIP8L2 Proteine) acts as a novel negative regulator of inflammatory and immune responses through TAK1 signaling.
this study shows that increased activity of TAK1 contributes to diabetic nephropathy
Salidroside (SDS (zeige SDS Proteine)) downregulated protein expression of toll-like receptor 4 (TLR4 (zeige TLR4 Proteine)) and CD14 (zeige CD14 Proteine). SDS (zeige SDS Proteine) inhibited LPS (zeige TLR4 Proteine)-triggered phosphorylation of LPS (zeige TLR4 Proteine)-activated kinase 1 (TAK1), p38 (zeige CRK Proteine), c-Jun (zeige JUN Proteine) terminal kinase (JNK (zeige MAPK8 Proteine)), and extracellular signal-regulated kinase (ERK (zeige EPHB2 Proteine)).
Members of the nuclear hormone receptor family, such as NR2C2, act as ligand-activated transcription factors. The proteins have an N-terminal transactivation domain, a central DNA-binding domain with 2 zinc fingers, and a ligand-binding domain at the C terminus. The activated receptor/ligand complex is translocated to the nucleus where it binds to hormone response elements of target genes (Yoshikawa et al., 1996
Nuclear hormone receptor TR4
, TR4 nuclear hormone receptor
, nuclear receptor subfamily 2 group C member 2
, orphan nuclear receptor TAK1
, orphan nuclear receptor TR4
, testicular nuclear receptor 4
, testicular receptor 4
, TR4 orphan receptor
, TR4-NS orphan receptor
, orphan receptor TR4
, nuclear receptor subfamily 2, group H, member 2
, orphan receptor, TR4