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These data are consistent with a model in which bivalent recruitment of a GADS/SLP-76 (zeige LCP2 Proteine) complex is required for costimulation by CD6 (zeige CD6 Proteine).
Following phosphorylation of the tyrosine, the proteins growth factor receptor-bound protein 2 (Grb2 (zeige GRB2 Proteine)), Grb2 (zeige GRB2 Proteine)-related adaptor downstream of Shc (zeige SHC1 Proteine) (Gads), and p85 subunit of phosphoinositide 3-kinase may bind to pYMNM (where pY is phosphotyrosine) via their Src (zeige SRC Proteine) homology 2 (SH2) domains, leading to downstream signaling to distinct immune pathways. These three adaptor proteins bind to the same site on CD28 (zeige CD28 Proteine) with variable affinity
GADS deficient T cells displayed similar levels of T cell receptor -induced SLP-76 (zeige LCP2 Proteine) and PLC-gamma1 (zeige PLCG1 Proteine) phosphorylation but exhibited substantial decrease in TCR-induced IL-2 (zeige IL2 Proteine) and IFN-gamma (zeige IFNG Proteine) release.
Gads was dispensable for TCR-induced phosphorylation of SLP-76 (zeige LCP2 Proteine), but was a dose-dependent amplifier of TCR-induced CD69 (zeige CD69 Proteine) expression.
GADS mediates lymphoid disease downstream of BCR-ABL (zeige ABL1 Proteine) through the recruitment of specific signaling intermediates.
Histidine domain-protein tyrosine phosphatase (zeige ACP1 Proteine) interacts with Grb2 (zeige GRB2 Proteine) and GrpL
The results show that Bcr-Abl (zeige ABL1 Proteine) regulates the actin cytoskeleton and non-apoptotic membrane blebbing via a GADS/Slp-76 (zeige LCP2 Proteine)/Nck1 (zeige NCK1 Proteine) adaptor protein pathway.
Exogenous expression of GrpL in a GrpL-negative B cell line leads to enhanced antigen receptor-induced extracellular signal-related kinase and p38 mitogen-activated protein kinase (zeige MAPK14 Proteine) phosphorylation.
AML-1 (zeige RUNX1 Proteine) plays a role in driving Mona (zeige MMP2 Proteine) protein expression in T and myelomonocytic cells.
Plays a tissue-specific role as an inhibitor of RET receptor tyrosine kinase (zeige RET Proteine) mitogenic signaling
High GADS expression is associated with neoplasms.
The combined loss of Gads and CD127 (zeige IL7R Proteine) reveals a novel function of Gads prior to T cell receptor beta expression
Data show that the primary function of Gads is to regulate the sensitivity of the TCR to Ag ligation.
Induced expression and association of the Mona/Gads adapter and Gab3 scaffolding protein (zeige GAB3 Proteine) during monocyte/macrophage differentiation. (Gab3 scaffolding protein (zeige GAB3 Proteine))
Results reveal the basis for preferential recognition of specific LAT (zeige LAT Proteine) sites by Gads.
Mona/Gads SH3C binding to hematopoietic progenitor kinase 1 (HPK1 (zeige MAP4K1 Proteine)) combines an atypical SH3 binding motif, R/KXXK, with a classical PXXP motif embedded in a polyproline type II (PPII) helix
The Gads adaptor protein is critical for homeostasis of CD4 (zeige CD4 Proteine)(+) T cells.
Selective impairment of FcepsilonRI (zeige FCER1A Proteine)-mediated allergic reaction in Gads-deficient mice
Gads plays a key role in linking the adapter LAT (zeige LAT Proteine) to SLP-76 (zeige LCP2 Proteine) in response to weak activation of GPVI (zeige GP6 Proteine) and CLEC-2 (zeige CLEC1B Proteine) whereas LAT (zeige LAT Proteine) is required for full activation over a wider range of agonist concentrations.
This gene encodes a member of the GRB2/Sem5/Drk family. This member is an adaptor-like protein involved in leukocyte-specific protein-tyrosine kinase signaling. Like its related family member, GRB2-related adaptor protein (GRAP), this protein contains an SH2 domain flanked by two SH3 domains. This protein interacts with other proteins, such as GRB2-associated binding protein 1 (GAB1) and the SLP-76 leukocyte protein (LCP2), through its SH3 domains. Transcript variants utilizing alternative polyA sites exist.
GRB2-related adaptor protein 2
, GRB2-related adapter protein 2
, GRB-2-like protein
, GRB2-related protein with insert domain
, SH3-SH2-SH3 adapter Mona
, SH3-SH2-SH3 adaptor molecule
, adapter protein GRID
, grf40 adapter protein
, growth factor receptor-binding protein
, growth factor receptor-bound protein 2-related adaptor protein 2
, hematopoietic cell-associated adapter protein GrpL
, hematopoietic cell-associated adaptor protein GRPL
, GRB-2-related monocytic adapter protein
, Grb2-related adaptor downstream of Sch
, hematopoietic cell-associated adaptor protein GrpL
, monocytic adapter
, monocytic adaptor