anti-Maus CD80 Antikörper für Functional Studies

Recommended CD80 Antibody (geliefert von: Anmelden zum Anzeigen )

Antigen
CD80 Antikörper
  • B7
  • B7-1
  • B7.1
  • BB1
  • CD28LG
  • CD28LG1
  • LAB7
  • B71
  • Cd28l
  • Ly-53
  • Ly53
  • MIC17
  • TSA1
  • CD80 molecule
  • Cd80 molecule
  • CD80 antigen
  • CD80
  • Cd80
Reaktivität
Maus, Hund
476
306
48
11
9
6
4
3
2
2
1
1
1
Wirt
Hamster
422
125
108
100
43
17
Klonalität
Monoklonal
Konjugat
Dieser CD80 Antikörper ist unkonjugiert
78
77
57
43
20
20
18
17
12
10
10
8
8
8
8
7
7
7
6
6
5
5
4
4
4
4
4
4
3
2
2
2
2
2
2
2
2
2
2
2
2
1
Applikation
Functional Studies (Func), Flow Cytometry (FACS), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunoprecipitation (IP)
557
211
173
152
121
93
74
44
38
27
26
18
9
8
7
6
6
5
5
4
2
2
2
2
1
1
1
Optionen
Hersteller
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Hersteller Produkt- Nr.
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Produktnummer ABIN489934
$ 189.75
Zzgl. Versandkosten $45.00
Relevance Score ABIN Application Konjugat Host Isotype Epitope Hersteller Clonality References Details
1 ABIN567985 Func IHC (fro) FACS IP Hamster IgG2 Anmelden zum Anzeigen 16-10A1 9
1 ABIN371006 Func FACS IP Rat IgG2a Anmelden zum Anzeigen 1G10 6
1 ABIN371007 Func FACS IP Rat IgG2a Anmelden zum Anzeigen 1G10 6
1 ABIN316878 Func FACS IHC (fro) Rat IgG2a Anmelden zum Anzeigen RM80 2
1 ABIN1967873 BR FACS Func IHC IHC (fro) IP Neut Hamster IgG2 Anmelden zum Anzeigen 16-10A1 0
1 ABIN600886 FACS Func IHC IHC (fro) Rat IgG2a Anmelden zum Anzeigen 0
1 ABIN3200026 FACS Func IHC (fro) IP Armenian Hamster IgG2 Anmelden zum Anzeigen 16-10A1 0
1 ABIN217761 FACS Func IHC IHC (fro) Rat IgG2a Anmelden zum Anzeigen 0
1 ABIN4282666 FACS Func IHC IHC (fro) IP Armenian Hamster IgG Anmelden zum Anzeigen 16-10A1 0
1 ABIN4282667 FACS Func IHC IHC (fro) IP Armenian Hamster IgG Anmelden zum Anzeigen 16-10A1 0
1 ABIN4282668 FACS Func IHC IHC (fro) IP Armenian Hamster IgG Anmelden zum Anzeigen 16-10A1 0
1 ABIN4282669 FACS Func IHC IHC (fro) IP Armenian Hamster IgG Anmelden zum Anzeigen 16-10A1 0
1 ABIN2567919 Func FACS Mouse IgG1 kappa Anmelden zum Anzeigen 2D10-4 0
1 ABIN2567925 Func FACS IF IP IHC Hamster IgG Anmelden zum Anzeigen 16-10A1 0
1 ABIN2567920 Func FACS Mouse IgG1 kappa Anmelden zum Anzeigen 2D10-4 0
1 ABIN2567926 Func FACS IP IHC Hamster IgG Anmelden zum Anzeigen 16-10A1 0
1 ABIN5574782 FACS Func IHC (fro) IP Hamster IgG2 Anmelden zum Anzeigen 16-10A1 0

General

Antigen CD80 Antikörper
Reaktivität Maus, Hund
(476), (306), (48), (11), (9), (6), (4), (3), (2), (2), (1), (1), (1)
Wirt Hamster
(422), (125), (108), (100), (43), (17)
Klonalität (Klon)
Monoklonal   ( )
Konjugat Dieser CD80 Antikörper ist unkonjugiert
(78), (77), (57), (43), (20), (20), (18), (17), (12), (10), (10), (8), (8), (8), (8), (7), (7), (7), (6), (6), (5), (5), (4), (4), (4), (4), (4), (4), (3), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1)
Applikation Functional Studies (Func), Flow Cytometry (FACS), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunoprecipitation (IP)
(557), (211), (173), (152), (121), (93), (74), (44), (38), (27), (26), (18), (9), (8), (7), (6), (6), (5), (5), (4), (2), (2), (2), (2), (1), (1), (1)
Pubmed 8 Publikationen vorhanden
Hersteller Anmelden zum Anzeigen

Produktdetails anti-CD80 Antikörper

Target Details CD80 Anwendungsinformationen Handhabung Referenzen für anti-CD80 Antikörper (ABIN489934) Bilder
Spezifität The Armenian hamster monoclonal antibody 16-10A1 reacts with CD80 (B7-1), a 60 kDa single chain type I glycoprotein of immunoglobulin supergene family, expressed on professional antigen-presenting cells, such as dendritic cells, macrophages or activated B lymphocytes.
Reinigung Purified from hybridoma culture supernatant by protein-A affinity chromatography.
Reinheit > 95 % (by SDS-PAGE)
Immunogen CD80-transfected CHO cell line
Klon 16-10A1
Isotyp IgG2

Target Details CD80

Produktdetails anti-CD80 Antikörper Anwendungsinformationen Handhabung Referenzen für anti-CD80 Antikörper (ABIN489934) Bilder zurück nach oben
Antigen
Andere Bezeichnung CD80 (CD80 Antibody Abstract)
Hintergrund CD80 (B7-1) and CD86 (B7-2) are ligands of T cell critical costimulatory molecule CD28 and of an inhibitory receptor CTLA-4 (CD152). The both B7 molecules are expressed on professional antigen-presenting cells and are essential for T cell activation, the both molecules can also substitute for each other in this process. The question what are the differences in CD80 and CD86 competency has not been fully elucidated yet, there are still conflicts in results about their respective roles in initiation or sustaining of the T cell immune response.
Gen-ID 12519
Pathways T-Zell Rezeptor Signalweg, Fc-epsilon Rezeptor Signalübertragung, EGFR Signaling Pathway, Neurotrophin Signalübertragung, Positive Regulation of Immune Effector Process

Anwendungsinformationen

Produktdetails anti-CD80 Antikörper Target Details CD80 Handhabung Referenzen für anti-CD80 Antikörper (ABIN489934) Bilder zurück nach oben
Applikations-hinweise Flow Cytometry: Recommended dilution: 6 µg/mL
Functional Application: Blocking

Working concentrations should be determined by the investigator.
Beschränkungen Nur für Forschungszwecke einsetzbar

Handhabung

Produktdetails anti-CD80 Antikörper Target Details CD80 Anwendungsinformationen Referenzen für anti-CD80 Antikörper (ABIN489934) Bilder zurück nach oben
Konzentration 1 mg/mL
Buffer Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.4
Konservierungs-mittel Sodium azide
Vorsichtsmaßnahmen This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handhabung Do not freeze.
Lagerung 4 °C
Informationen zur Lagerung Store at 2-8 °C. Do not use after expiration date stamped on vial label.

Referenzen für anti-CD80 Antikörper (ABIN489934)

Produktdetails anti-CD80 Antikörper Target Details CD80 Anwendungsinformationen Handhabung Bilder zurück nach oben
Produkt verwendet in:

Mukherjee, Ahmed, Malu, Nandi: "Modulation of cell cycle progression by CTLA4-CD80/CD86 interactions on CD4+ T cells depends on strength of the CD3 signal: critical role for IL-2." in: Journal of leukocyte biology, Vol. 80, Issue 1, pp. 66-74, 2006

Odobasic, Kitching, Semple, Timoshanko, Tipping, Holdsworth: "Glomerular expression of CD80 and CD86 is required for leukocyte accumulation and injury in crescentic glomerulonephritis." in: Journal of the American Society of Nephrology : JASN, Vol. 16, Issue 7, pp. 2012-22, 2005

Paust, Lu, McCarty, Cantor: "Engagement of B7 on effector T cells by regulatory T cells prevents autoimmune disease." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 101, Issue 28, pp. 10398-403, 2004

Quah, Ni, ONeill: "In vitro hematopoiesis produces a distinct class of immature dendritic cells from spleen progenitors with limited T cell stimulation capacity." in: International immunology, Vol. 16, Issue 4, pp. 567-77, 2004

Reiser, von Gersdorff, Loos, Oh, Asanuma, Giardino, Rastaldi, Calvaresi, Watanabe, Schwarz, Faul, Kretzler, Davidson, Sugimoto, Kalluri, Sharpe, Kreidberg, Mundel: "Induction of B7-1 in podocytes is associated with nephrotic syndrome." in: The Journal of clinical investigation, Vol. 113, Issue 10, pp. 1390-7, 2004

Gueirard, Ave, Balazuc, Thiberge, Huerre, Milon, Guiso: "Bordetella bronchiseptica persists in the nasal cavities of mice and triggers early delivery of dendritic cells in the lymph nodes draining the lower and upper respiratory tract." in: Infection and immunity, Vol. 71, Issue 7, pp. 4137-43, 2003

Mencacci, Montagnoli, Bacci, Cenci, Pitzurra, Spreca, Kopf, Sharpe, Romani: "CD80+Gr-1+ myeloid cells inhibit development of antifungal Th1 immunity in mice with candidiasis." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 169, Issue 6, pp. 3180-90, 2002

Horspool, Perrin, Woodcock, Cox, King, June, Harlan, St Louis, Lee: "Nucleic acid vaccine-induced immune responses require CD28 costimulation and are regulated by CTLA4." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 160, Issue 6, pp. 2706-14, 1998