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anti-Human NR2F2 Antikörper:
anti-Mouse (Murine) NR2F2 Antikörper:
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Cow (Bovine) Polyclonal NR2F2 Primary Antibody für IHC, WB - ABIN2792599
Sato, Suzuki, Hidaka, Sato, Ito, Ito, Sasano: Immunolocalization of nuclear transcription factors, DAX-1 and COUP-TF II, in the normal human ovary: correlation with adrenal 4 binding protein/steroidogenic factor-1 immunolocalization during the menstrual cycle. in The Journal of clinical endocrinology and metabolism 2003
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Cow (Bovine) Polyclonal NR2F2 Primary Antibody für WB - ABIN2781131
Cho, Yi, Tserentsoodol, Searle, Ferreira: Neuroprotection resulting from insufficiency of RANBP2 is associated with the modulation of protein and lipid homeostasis of functionally diverse but linked pathways in response to oxidative stress. in Disease models & mechanisms 2010
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Results suggest that xCOUP-TF and xCyp26 are both regulated by Wnt signaling, and cooperatively function in retinoic acid (RA) signaling to affect anterior-posterior (A-P) neural patterning.
Both in zebrafish and Xenopus the development of the main lymphatic structures was severely hampered.
Study results revealed that COUPTFII knockdown significantly inhibited colorectal cancer invasion and migration. Expression of miR34a was revealed to be inversely correlated with COUPTFII expression. High COUP-TFII expression competitively inhibited miR-34a transcription, thereby promoting the epithelialmesenchymal transition process. These results indicated that COUP-TFII and miR-34a may regulate each other.
These findings suggested NR2F2 as a novel susceptibility gene of human congenital bicuspid aortic valve.
Genetic and Epigenetic Profiling Reveals EZH2-mediated Down Regulation of OCT-4 Involves NR2F2 during Cardiac Differentiation of Human Embryonic Stem Cells.
The interaction is known to control gluconeogenesis, principally through direct binding of COUP-TFII/Glucocorticoid Receptor (GR) complexes to the promoters of gluconeogenic enzyme genes.
A pathogenic NR2F2 variant (c.856dupG, p.Val286Glyfs*23) caused syndromic forms of congenital heart defect.
heterozygous frameshift mutations in NR2F2, encoding COUP-TF2, were identified in three children.
High COUP-TFII expression is associated with increased lymphangiogenesis and lymph node metastasis in prostate adenocarcinoma.
NR2F2 loss-of-function mutation is associated with increased susceptibility to double outlet right ventricle and ventricular septal defect .
The results of the present study suggest that COUPTFII functions as a significant regulatory suppressor of gastric cancer growth and metastasis, and suggests that COUPTFII may serve as a novel diagnostic and prognostic biomarker for gastric cancer metastasis.
COUP-TFII is a critical factor controlling metastatic gene networks to promote prostate cancer metastasis.
fifth of COUP-TFI cells also co-expressed COUP-TFII, and cells expressing either transcription factor followed posterior or anterio-lateral pathways into the cortex
Dividing COUP-TFII+ progenitor cells were localized to ventral CGE
We showed that the orphan receptor COUP-TFII is an important player in hepatic neoangiogenesis. COUP-TFII expression in hepatic stellate cells (HSC) controls the crosstalk between hepatic HSC and endothelial cells coordinating vascular remodelling during liver injury.
Low COUPTFII expression is associated with prostate cancer.
We conclude that COUP-TFII mutations can cause diaphragmatic hernias, and should be included in the differential diagnosis of CDH patients, particularly those with comorbid congenital heart defects.
Studied the role of Nuclear receptor subfamily 2 group F member 2 (NR2F2) in MSC chondrogenesis in bioprinted cartilage. NR2F2 over-expressed MSCs showed significantly enhanced chondrogenesis while NR2F2 knockdown cells demonstrated the exactly opposite behavior.
NR2F2 is a Direct Target Gene of miR-382 in colorectal cancer.
Results indicate that COUP-TFII may play an oncogenic role in RCC, and COUP-TFII may promote tumor progression through inhibiting BRCA1.
MicroRNA-27b was targeted and down-regulated by NR2F2 in human gastric cancer tissues and cells.
NR2F2 could promote TGF-beta-induced epithelial-mesenchymal transition of colorectal carcinoma cells and inhibit Smad7 expression via transactivation of miR-21.
Study shows that COUP-TFII is expressed in the subpopulation of neural crest cells (NCCs) and its derivatives, and targeted ablation of COUP-TFII in mouse NCCs results in markedly shortened and bifurcated tympanic rings, which in turn disturb the caudal direction of external acoustic meatus invagination.
Study demonstrated mechanistically that COUP-TFII repressed myogenesis through direct transcriptional repression of genes important for myoblast fusion as well as inhibition of FAK activation.
elimination of Wolffian ducts in female embryos is actively promoted by COUP-TFII, which suppresses a mesenchyme-epithelium cross-talk responsible for Wolffian duct maintenance.
Together, these results imply that Tie2 is essential for venous specification and maintenance via Akt mediated stabilization of COUP-TFII.
Coup-TF1 and Coup-TF2 control subtype and laminar identity of MGE-derived neocortical interneurons
A regulatory role of COUP-TFII in the development of muscular dystrophy.
FGF2 is an extracellular inducer of COUP-TFII expression and may suppress the osteogenic potential of mesenchymal cells by inducing COUP-TFII expression prior to the onset of osteogenic differentiation
results identify a novel cooperation between MEF2 factors and NR2F2 in the expression of the Akr1c14 gene
These in vitro and in vivo data support an anti-adipogenic role of COUP-TFII via downregulating the Notch signaling target gene Hey1.
Myocardial Nr2f2 overexpression causes heart failure. Nr2f2 represses genes critical for mitochondrial ETC enzyme activity, oxidative stress detoxification and mitochondrial dynamics, resulting in increased ROS and lower rates of oxygen consumption.
Data show that Chicken ovalbumin upstream promoter transcription factor II (COUP-TFII)-induced expression of Neuropilin-2 (Nrp2) and its down-regulation control the destination of preoptic area (POa)-derived GABAergic neurons.
These data demonstrate that Nr2f2 is a direct target of POU4F3 in vitro and that this regulatory relationship may be relevant to hair cell development and survival.
COUP-TFII cooperates with the nuclear receptor steroidogenic factor 1 (SF1) to further enhance Insl3 promoter activity in Leydig cells.
Postnatal increase in hepatic COUP-TFII gene expression is involved in the regulation of liver fatty acid oxidation, which in turn sustains an active hepatic gluconeogenesis essential to maintain blood glucose level required for newborn mice survival.
Transcription factors COUP-TFI and COUP-TFII are required for the production of granule cells in the mouse olfactory bulb.
MicroRNA-194 reciprocally stimulates osteogenesis and inhibits adipogenesis via regulating COUP-TFII expression.
miR-302a is induced by osteogenic stimuli and promotes osteoblast differentiation by targeting Chicken ovalbumin upstream promoter transcription factor II
These data identify an essential role for the nuclear receptor NR2F2 as a direct activator of Star gene expression in Leydig cells, and thus in the control of steroid hormone biosynthesis.
Critical function of proinflammatory cytokines and the COUP-TFII regulatory gene network in the progression of endometriosis.
Using nr2f1a and nr2f2 mutants, we find that Nr2f1a and Nr2f2 have redundant requirements restricting ventricular cardiomyocyte number and promoting development of the posterior pharyngeal muscles.
Sox7/18 factors and Notch regulate nr2f2 gene expression during venous differentiation in zebrafish.
absence of NR2F2 in zebrafish resulted in distinct vascular defects including loss of venous marker expression, major trunk vessel fusion and vascular leakage.
Results show that chicken ovalbumin upstream promoter transcription factor II (COUP-TFII), hepatocyte nuclear factor 4alpha (HNF-4alpha) and HNF-4gamma regulate growth hormone receptor 1A promoter activity by binding to a common DNA element
Involvement of Ad4BP/SF-1, DAX-1, and COUP-TFII transcription factor on steroid production and luteinization in ovarian theca cells.
This gene encodes a member of the steroid thyroid hormone superfamily of nuclear receptors. The encoded protein is a ligand inducible transcription factor that is involved in the regulation of many different genes. Alternate splicing results in multiple transcript variants.
nuclear receptor subfamily 2, group F, member 2
, ADP-ribosylation factor related protein 1
, COUP transcription factor 2
, COUP transcription factor II
, apolipoprotein A-I regulatory protein 1
, apolipoprotein AI regulatory protein 1
, chicken ovalbumin upstream promoter transcription factor 2
, chicken ovalbumin upstream promoter-transcription factor I
, chicken ovalbumin upstream promoter-transcription factor II variant 1
, chicken ovalbumin upstream promoter-transcription factor II variant 2
, chicken ovalbumin upstream promoter-transcription factor II variant 3
, COUP-TF II
, apolipoprotein regulatory protein 1
, ovalbumin upstream promoter beta nuclear receptor
, seven-up related 40
, nuclear receptor subfamily 2 group F member 2
, apolipoprotein A1 regulatory protein 1
, nuclear receptor subfamily 2, group F, member 1
, transcription factor COUP 2