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anti-Human RAB5 Antikörper:
anti-Mouse (Murine) RAB5 Antikörper:
anti-Rat (Rattus) RAB5 Antikörper:
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Human Polyclonal RAB5 Primary Antibody für ICC, IF - ABIN266020
Sönnichsen, De Renzis, Nielsen, Rietdorf, Zerial: Distinct membrane domains on endosomes in the recycling pathway visualized by multicolor imaging of Rab4, Rab5, and Rab11. in The Journal of cell biology 2000
Show all 8 Pubmed References
Human Monoclonal RAB5 Primary Antibody für ELISA, WB - ABIN519585
Chamberlain, Oberg, Furber, Poland, Hawrysh, Knafelc, McBride, Anderson: Deregulation of Rab5 and Rab4 proteins in p85R274A-expressing cells alters PDGFR trafficking. in Cellular signalling 2010
Cow (Bovine) Polyclonal RAB5 Primary Antibody für IHC, WB - ABIN2786773
Coyne, Shen, Turner, Bergelson: Coxsackievirus entry across epithelial tight junctions requires occludin and the small GTPases Rab34 and Rab5. in Cell host & microbe 2007
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Human Polyclonal RAB5 Primary Antibody für IP, WB - ABIN1742215
Perlini, Botti, Fornasiero, Giannandrea, Bonanomi, Amendola, Naldini, Benfenati, Valtorta: Effects of phosphorylation and neuronal activity on the control of synapse formation by synapsin I. in Journal of cell science 2011
Human Monoclonal RAB5 Primary Antibody für ICC, IP - ABIN1742214
Seipold, Damme, Prox, Rabe, Kasparek, Sedlacek, Altmeppen, Willem, Boland, Glatzel, Saftig: Tetraspanin 3: A central endocytic membrane component regulating the expression of ADAM10, presenilin and the amyloid precursor protein. in Biochimica et biophysica acta 2016
Cow (Bovine) Polyclonal RAB5 Primary Antibody für ICC, IF - ABIN361846
Ali, Wasmeier, Lamoreux, Strom, Seabra: Multiple regions contribute to membrane targeting of Rab GTPases. in Journal of cell science 2004
Show all 7 Pubmed References
Horse (Equine) Polyclonal RAB5 Primary Antibody für ICC, IF - ABIN4891966
Pera, Larrea, Guardia-Laguarta, Montesinos, Velasco, Agrawal, Xu, Chan, Di Paolo, Mehler, Perumal, Macaluso, Freyberg, Acin-Perez, Enriquez, Schon, Area-Gomez: Increased localization of APP-C99 in mitochondria-associated ER membranes causes mitochondrial dysfunction in Alzheimer disease. in The EMBO journal 2017
The authors demonstrate that RABGEF1 (zeige RABGEF1 Antikörper), the upstream factor of the endosomal Rab GTPase (zeige RAB6A Antikörper) cascade, is recruited to damaged mitochondria via ubiquitin binding downstream of Parkin (zeige PARK2 Antikörper). RABGEF1 (zeige RABGEF1 Antikörper) directs the downstream Rab (zeige HRB Antikörper) proteins, RAB5 and RAB7A (zeige RAB7A Antikörper), to damaged mitochondria, whose associations are further regulated by mitochondrial Rab (zeige HRB Antikörper)-GAPs.
Low RAB5 expression is associated with glioma progression.
The expression level of EMC-6 is significantly elevated in cervical cancer, without significant correlation with Beclin1 (zeige BECN1 Antikörper) and Rab5a.
Here the authors show that Rab5 is monoubiquitinated on K116, K140, and K165. Structural analysis combined with biochemical data revealed that interactions with downstream effectors were impeded in Rab5 monoubiquitinated at K140, whereas GDP release and GTP (zeige AK3 Antikörper) loading activities were altered in Rab5 monoubiquitinated at K165.
Rab5a is overexpressed in oral cancer tissue samples and promotes the malignant phenotype through EMT (zeige ITK Antikörper) and the ERK (zeige EPHB2 Antikörper)/MMP2 (zeige MMP2 Antikörper) signaling pathway.
Rab5 was found abundantly localized in macrophage rich areas of human atherosclerotic lesions.Rab5 plays an important role in modulating the intracellular cholesterol of macrophages and consequently mediating the formation of foam cells.
The results were indicative that rabies virus N proficiently colocalized with Rab5/EEA1 (zeige EEA1 Antikörper) and Rab7 (zeige RAB7B Antikörper)/LAMP1 (zeige LAMP1 Antikörper) in both cell lines at 24 and 48 h post-infection, while N titers significantly decreased in early infection of rabies virus.
Membrane localization and dynamics of geranylgeranylated Rab5 hypervariable region has been reported.
study elucidated a novel Malat1-miR-101-STMN1/RAB5A/ATG4D regulatory network that Malat1 activates autophagy and promotes cell proliferation by sponging miR-101 and upregulating STMN1, RAB5A and ATG4D expression in glioma cells
In conclusion, mutant KRAS promotes endosomal degradation in PDAC cell lines, which is impaired by KRAS silencing. Moreover, KRAS silencing activates RAB5A upregulation and drives PDAC subtype-dependent modulation of endosome trafficking.
The authors described a long-distance signaling mechanism of Porcine hemagglutinating encephalomyelitis virus-driven deficits in neurons and suggested that such Ulk1 (zeige ULK1 Antikörper) repression may result in limited NGF (zeige NGFB Antikörper)/TrkA (zeige NTRK1 Antikörper) retrograde signaling within activated Rab5 endosomes, explaining the progressive failure of neurite outgrowth and survival.
SH3GLB1 (zeige SH3GLB1 Antikörper) controls nicotinic acetylcholine receptors endocytic trafficking in a phosphorylation- and RAB5-dependent manner at steps upstream of autophagosome formation.
E. chaffeensis secretes Etf-1 (zeige ETF1 Antikörper) to induce autophagy to repurpose the host cytoplasm and capture nutrients for its growth through RAB5 and class III PtdIns3K, while avoiding autolysosomal killing.
These data highlight a requirement of Rab5 and the endosomal system for the regulation of gluconeogenic gene expression that has important implications for metabolic diseases.
Inpp5e (zeige INPP5E Antikörper), through functional interactions with Rab20 (zeige RAB20 Antikörper) on the phagosome, activates Rab5, which, in turn, increases PtdIns3P and delays phagosome acidification.
FGF21 (zeige FGF21 Antikörper) has a role in promoting endothelial cell angiogenesis through a dynamin-2 (zeige DNM2 Antikörper) and Rab5 dependent pathway
In silico screening for palmitoyl substrates reveals a role for DHHC1/3/10 (zDHHC1/3/11)-mediated neurochondrin (zeige NCDN Antikörper) palmitoylation in its targeting to Rab5-positive endosomes.
In mammalian cells, p110beta acts as a molecular sensor for growth factor availability and induces autophagy by activating a Rab5-mediated signaling cascade.
Data show that Rinl is closely associated with the cytoskeleton and thus contributes to the spatial control of Rab5a and Rab22 signaling at actin-positive compartments.
Data reveal the affinity of Rabex-5 (zeige RABGEF1 Antikörper)/Rabaptin-5 (zeige RABEP1 Antikörper)/Rab5-GTP (zeige AK3 Antikörper) interaction in the cell, which is quantitatively related to the Rabex-5 (zeige RABGEF1 Antikörper) concentration for the onset of the indirect
Expression of dominant negative Rab5 and Rab7 (zeige RAB7A Antikörper) mutants, but not the dominant negative Rab11 (zeige RAB11A Antikörper) mutant, significantly inhibited classical swine fever virus replication. These results were confirmed by silencing of Rab5 and Rab7 (zeige RAB7A Antikörper).
Dominant-negative mutant rab5 inhibits FMDV infection of IBRS-2 cells.
Required for the fusion of plasma membranes and early endosomes (By similarity).
, Rab5a, GTPase
, hypothetical protein
, Ras-related protein Rab-5A
, ras-related protein rab-5a
, RAB5A, member RAS oncogene family
, ras-related protein Rab-5A
, RAS-associated protein RAB5A
, small GTP-binding protein rab5
, GTP-binding protein (rab5)