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anti-Rat (Rattus) WASF2 Antikörper:
anti-Human WASF2 Antikörper:
anti-Mouse (Murine) WASF2 Antikörper:
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Bat Polyclonal WASF2 Primary Antibody für WB - ABIN610903
Frain, Swart, Monaci, Nicosia, Stämpfli, Frank, Cortese: The liver-specific transcription factor LF-B1 contains a highly diverged homeobox DNA binding domain. in Cell 1989
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Results show that in cisplatin-resistant cervical cancer tissues, Rac1 (zeige RAC1 Antikörper), and Wave2 mRNA expression was significantly up-regulated compared to that of the cisplatin-sensitive cervical cancer tissues. In HeLa and Caski cervical cancer cell lines, Rac1 (zeige RAC1 Antikörper) activity and Wave2 protein expression was significantly promoted by SH3BP1 (zeige SH3BP1 Antikörper) overexpression.
Studied leucine rich repeat kinase 2 (LRRK2)-WAS protein family member 2 (WAVE2) pathway in modulation of phagocytosis in leukocytes, as well as its possible role for altered immune function in Parkinson's Disease.
The level of WASF2 in gastric cancer tissues was negatively correlated with miR (zeige MLXIP Antikörper)-146a expression and had inverse clinicopathologic features. The newly identified miR (zeige MLXIP Antikörper)-146a/WASF2 axis may provide a novel therapeutic target for gastric cancer.
These findings indicate that inhibition of the Rac1WAVE2Arp2/3 signaling pathway may promote radiosensitivity, which may partially result from the downregulation of CFL1 (zeige VPS72 Antikörper) in U251 human glioma cells.
SH3BP1 (zeige SH3BP1 Antikörper) promoted VEGF (zeige VEGFA Antikörper) secretion via Rac1 (zeige RAC1 Antikörper)-WAVE2 signaling, so as to exert an augmentation on cell invasion and microvessel formation.
the MCP1 (zeige CCL2 Antikörper)-induced cortactin (zeige CTTN Antikörper) phosphorylation is dependent on PLCb3 (zeige PLCB3 Antikörper)-mediated PKC (zeige PRRT2 Antikörper) activation, and siRNA-mediated down-regulation of either of these molecules prevents cortactin (zeige CTTN Antikörper) interaction with WAVE2
WASp and WAVE2 differ in their dynamics and their associated proteins
these results suggest that Arp2 (zeige ACTR2 Antikörper)/3 and the upstream regulator, WAVE2, are essential co-factors hijacked by HIV for intracellular migration, and may serve as novel targets to prevent HIV transmission.
WAVE2 is down-regulated in gastric cancer
Cortactin (zeige CTTN Antikörper) has a role as a scaffold for Arp2 (zeige ACTR2 Antikörper)/3 and WAVE2 at the epithelial zonula adherens
TrkC (zeige NTRK3 Antikörper) signals to the podocyte actin cytoskeleton to induce migration by phosphorylating WAVE2 Erk (zeige EPHB2 Antikörper) dependently. This signaling mechanism may be important for TrkC (zeige NTRK3 Antikörper)-mediated cytoskeletal dynamics in podocyte disease.
Rho family GTPases use the I-BAR proteins, IRSp53 (zeige BAIAP2 Antikörper) (also known as BAIAP2 (zeige BAIAP2 Antikörper)), IRTKS (zeige BAIAP2L1 Antikörper) and Pinkbar (zeige BAIAP2L2 Antikörper), as a central mechanism to modulate cell morphology.
Data show that the primary effect of costimulation blockade was to decrease recruitment of the activator of actin nucleation WAVE2 (Wiskott-Aldrich syndrome protein family member protein 2) and cofilin (actin-severing protein) to F-actin.
The expression of NESH/Abi-3 (zeige ABI3 Antikörper) caused degradation of endogenous Abi-1 (zeige ABI1 Antikörper), which led to the formation of a NESH/Abi-3 (zeige ABI3 Antikörper)-based WAVE2 complex.
This study demonstrated that WAVE2-Abi2 (zeige ABI2 Antikörper) complex, which controls growth cone activity, is crucial for completing transition from a multipolar to bipolar shape.
Results of the present study show that the nucleation-promoting factors JMY (zeige JMY Antikörper) and WAVE2 are critical for cytokinesis during development of mouse embryos.
These results identify Wasf2 as a novel target of intermittent PTH administration via the Wnt and phosphoinositide-dependent protein kinase signaling pathways.
The protein and messenger RNA levels of WAVE2 were decreased in aged oocytes, but the levels were normal in caffeine-treated aged oocytes.
mDia1 and WAVE2 are important Src (zeige SRC Antikörper) homology 3 domain partners of IRSp53 (zeige BAIAP2 Antikörper) in forming filopodia.
WAVE2 regulates oocyte polarization by regulating meiotic spindle, peripheral positioning, probably via an actin-mediated pathway, and is involved in polar body emission during mouse oocyte meiotic maturation.
This gene encodes a member of the Wiskott-Aldrich syndrome protein family. The gene product is a protein that forms a multiprotein complex that links receptor kinases and actin. Binding to actin occurs through a C-terminal verprolin homology domain in all family members. The multiprotein complex serves to tranduce signals that involve changes in cell shape, motility or function. The published map location (PMID:10381382) has been changed based on recent genomic sequence comparisons, which indicate that the expressed gene is located on chromosome 1, and a pseudogene may be located on chromosome X. Two transcript variants encoding different isoforms have been found for this gene.
WAS protein family, member 2
, wiskott-Aldrich syndrome protein family member 2
, WASP family Verprolin-homologous protein 2
, WASP family protein member 2
, WASP family protein member 4
, protein WAVE-2
, putative Wiskott-Aldrich syndrome protein family member 4
, suppressor of cyclic-AMP receptor (WASP-family)
, verprolin homology domain-containing protein 2