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Our findings showed that increased expression of CD34 (zeige CD34 Proteine) and CD117 markers confer tumor progression and aggressiveness on prostate cancer.
A phase Ib study of dasatinib plus ipilimumab in patients with gastrointestinal stromal tumor (GIST) and other sarcomas was performed on the basis of preclinical data demonstrating that combined KIT and CTLA-4 (zeige CTLA4 Proteine) blockade is synergistic.
4 different mutant (MT-KIT) KIT proteins from GIST tumors are intrinsically less stable than wild-type KIT due to proteasome-mediated degradation and abnormally localized to the endoplasmic reticulum or the Golgi complex. PKC-theta (zeige PRKCQ Proteine); is strongly and exclusively expressed in GISTs and interacts with intracellular MT-KIT to promote its stabilization by increased retention in the Golgi complex.
Report a new in vivo model of KIT D816V+ advanced systemic mastocytosis developed by transplantation of the human ROSAKIT D816V-Gluc (zeige GBA Proteine) mast cell line in NOD-SCID (zeige PRKDC Proteine) IL-2R gamma (zeige IL2RG Proteine)-/- mice, using Gaussia princeps luciferase as a reporter.
KIT D816V mutation sensitized mast cells from systemic mastocytosis patients to histone deacetylase (zeige HDAC1 Proteine) inhibitor mediated killing.
the presented study demonstrates that CBFB-MYH11-based MRD status during the first 3 months after allo-HCT, but not KIT mutations, can be used to identify patients with a high risk of relapse.
Hedgehog (zeige SHH Proteine) pathway dysregulation contributes to the pathogenesis of human gastrointestinal stromal tumors via GLI (zeige GLI1 Proteine)-mediated activation of KIT expression.
findings that the CD56 (zeige NCAM1 Proteine) and CD117 expression levels are lower in advanced stages than earlier stages and that LDH level and CD117 expression have an inverse relationship in patients with newly diagnosed multiple myeloma (MM) suggest that CD56 (zeige NCAM1 Proteine) and CD117 expressions may be prognostic markers for MM.
activation of KIT by a gain-of-function, somatic mutation is a novel mechanism of resistance to crizotinib in ROS1 rearranged non-small cell lung cancer
Mutational activation of Kit-, Ras/Raf (zeige RAF1 Proteine)/Erk (zeige EPHB2 Proteine)- and Akt (zeige AKT1 Proteine)- pathways indicate the biological importance of these pathways and their components as potential targets for therapy.
Activation of c-kit signalling by SCF (zeige KITLG Proteine) promotes migration of cardiac stem cells with increased phosphorylation of CXCR4 (zeige CXCR4 Proteine)-serine 339, p38 mitogen-activated protein kinase (p38 MAPK (zeige MAPK14 Proteine)) and extracellular regulated protein kinases 1/2 (ERK1/2).
c-Kit(+) Adipose tissue-derived mesenchymal stem cells (ASCs)may promote breast cancer growth and angiogenesis by a synergistic effect of c-Kit and IL-3. Our findings suggest that c-Kit(+) subpopulations of ASCs should be eliminated in fat grafts for breast reconstruction of cancer patients following mastectomy.
exposure of HSPCs to SCF and diminished number of c-Kit receptors in their cell membranes do not compromise the capacity of HSPCs to reconstitute damaged hematopoietic tissue.
the stem cell gene Kit is regulated inversely from Krt5 (zeige KRT5 Proteine)/Krt14 (zeige KRT14 Proteine) by RA signaling
TPO (zeige THPO Proteine) and its receptor Mpl (zeige MPL Proteine) are dispensable for platelet survival in adult mice
Artificially applied c-kit(+) cells interact with the target organ endothelium following ischemia reperfusion injury. This interaction seems to depend on TLR-MyD88 (zeige MYD88 Proteine) signaling.
a critical role for PRL2 phosphatase in mediating Notch and c-Kit signals in early T cell progenitors, is reported.
These results suggest that CD44 (zeige CD44 Proteine)(+)CD117(+) T cells are stem cells and a specific T-cell phenotype that initially develops in the thymus, but they do not progress through DN3 and DN4 stages, lack a DP stage, and potently suppress T-cell proliferation and modulate the CTLA-4 (zeige CTLA4 Proteine) pathway.
we studied the efficacy of ACK2, an antibody that blocks KIT, followed by low-dose irradiation as a preconditioning regimen for hematopoietic cell transplantation using a murine model of Mucopolysaccharidosis type II.
C-kit-positive hematopoietic stem/progenitor cells expressed significantly higher of Nox1 (zeige NOX1 Proteine) and catalase (zeige CAT Proteine), but less of lactoperoxidase (zeige LPO Proteine) than in matured mononuclear cells.
FGF7 (zeige FGF7 Proteine) may be an important regulator for oocyte growth and its action is mediated via the KIT/KITLG (zeige KITLG Proteine) signaling pathway.
mRNA expression of c-kit and SCF was decreased in gallbladder tissues in the HCD group. Consistent with the findings of RT-PCR, a lower expression level of c-kit and SCF protein was also observed in HCD animals.
Delayed enrichment for c-kit and inducing cardiac differentiation attenuated protective effects of BMSCs' transplantation in pig model of acute myocardial infarction.
Pravastatin improves function in hibernating myocardium by mobilizing CD133+ and cKit+ bone marrow progenitor cells and promoting myocytes to reenter the growth phase of the cardiac cell cycle.
c-kit is primarily expressed in the spermatogonia and spermatocytes of goat testes.
This gene encodes the human homolog of the proto-oncogene c-kit. C-kit was first identified as the cellular homolog of the feline sarcoma viral oncogene v-kit. This protein is a type 3 transmembrane receptor for MGF (mast cell growth factor, also known as stem cell factor). Mutations in this gene are associated with gastrointestinal stromal tumors, mast cell disease, acute myelogenous lukemia, and piebaldism. Multiple transcript variants encoding different isoforms have been found for this gene.
mast/stem cell growth factor receptor Kit
, p145 c-kit
, piebald trait protein
, proto-oncogene c-Kit
, proto-oncogene tyrosine-protein kinase Kit
, soluble KIT variant 1
, tyrosine-protein kinase Kit
, v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene-like protein
, Dominant white spotting
, Steel Factor Receptor
, c-kit proto-oncogene protein
, dominant spotting
, spotted sterile male
, c-kit receptor tyrosine kinase
, mast/stem cell growth factor receptor
, protein kinase
, c-kit receptor
, mast cell growth factor receptor
, c-KIT gene1
, receptor tyrosine kinase c-kit
, Mast/stem cell growth factor receptor
, Proto-oncogene c-Kit
, Tyrosine-protein kinase Kit
, caprine c-kit protein