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These findings suggested that miR (zeige MLXIP Proteine)-204 might serve as a tumor suppressor in the development of cervical cancer by directly targeting EphB2.
EphB2 signaling-mediated Sirt3 (zeige SIRT3 Proteine) expression reduces MSC (zeige MSC Proteine) senescence by maintaining mitochondrial reactive oxygen species homeostasis.
This study showed that EphB2 cells have a transient increase in migration after heterotypic activation, which underlies a shift in the EphB2-ephrinB1 (zeige EFNB1 Proteine) border but is not required for segregation or border sharpening.
This is the first study to link SLC1A3 (zeige SLC1A3 Proteine) and EPHB2 to clinically relevant vertebral osteoporosis phenotypes.
Data show that EPHB2 predicted poor breast cancer survival and EPHB2 protein expression has also prognostic value depending on cell localization.
showed that patients with SSc (zeige CYP11A1 Proteine) or SLE have AAb against EphB2, a protein involved in angiogenesis, and THEX1 (zeige ERI1 Proteine), a 3'-5' exoribonuclease involved in histone mRNA degradation. We have further identified a peptide from EphB2 as a specific and sensitive tool for SLE diagnosis
show that expression of EPHB2 and SNAIL1 (zeige SNAI1 Proteine) - an inducer of epithelial-mesenchymal transition (EMT (zeige ITK Proteine)) - is anti-correlated in colorectal cancer cell lines and tumors
Tiam2 (zeige TIAM2 Proteine)/Rac (zeige AKT1 Proteine) are key components of EphB2 trans-endocytosis and are important for cell repulsion.
High expression of junctional adhesion molecule-A (zeige F11R Proteine) and EphB2 can predict poor overall survival and high mortality rate, and EphB2 is an independent prognostic biomarker in lung adenocarcinoma patients.
Data show that activation of EphB2 receptor kinase arrests tau protein hyperphosphorylation through phosphatidylinositol 3-kinase (PI3K)/Akt protein-mediated glycogen synthase kinase-3beta (GSK-3beta) inhibition.
although both EphB2 and EphB3 (zeige EPHB3 Proteine) are necessary for cortical thymic epithelial maturation, the relevance of EphB3 (zeige EPHB3 Proteine) is greater since EphB3 (zeige EPHB3 Proteine)-/- thymic cortex exhibits a more severe phenotype than that of EphB2-deficient thymuses
ephrin-B2 (zeige EFNB2 Proteine) and EphA4 (zeige EPHA4 Proteine) have graded and modular expression patterns in the developing inferior colliculus
Overexpression of EphB2 also rescued the ADDLs-induced depletion of the expression of EphB2 and GluN2B (zeige GRIN2B Proteine)-containing NMDA receptors trafficking in cultured hippocampal neurons.
ephrin B3 (zeige EFNB3 Proteine)/EphB2 are obvious candidates for driving the Syk (zeige SYK Proteine)-dependent repulsive response.
The results of this study indicated that the decrease in spine density in the mPFC was associated with susceptibility to stress, and EphB2 downregulation in the mPFC increased the vulnerability to stress.
We here identify that EphB2 receptor tyrosine kinase (zeige ERBB3 Proteine), which is specifically expressed in glutamatergic neurons, is required for the innate fear responses in the neonatal brain.
Here, we identified the interaction sites of the EphB2 FN domain with ADDLs for the first time to develop a small (10 aa) peptide (Pep63) capable of blocking the EphB2-ADDL (zeige ADD3 Proteine) interaction.
EphB4 (zeige EPHB4 Proteine) plays an irreplaceable role in bone regeneration in an inflammatory microenvironment, whereas the functional loss of ephrinB2 (zeige EFNB2 Proteine) can be effectively compensated, most possibly by other ephrins with similar chemical structures
Authors suggest that aging is accompanied by the upregulation of miR-204 in the hippocampus, which downregulates EphB2 and results in reduced surface and total NR1 expression.
Findings suggest that a combination of forward and reverse EphB1 (zeige EPHB1 Proteine)/2 receptor-mediated signaling contribute to posterior branch of the anterior commissure and corpus callosum axon guidance
Ephrin receptors and their ligands, the ephrins, mediate numerous developmental processes, particularly in the nervous system. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. The Eph family of receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Ephrin receptors make up the largest subgroup of the receptor tyrosine kinase (RTK) family. The protein encoded by this gene is a receptor for ephrin-B family members.
ephrin receptor EphB2
, EPH receptor B2
, ephrin type-B receptor 2-like
, EPH-like kinase 5
, developmentally-regulated Eph-related tyrosine kinase
, elk-related tyrosine kinase
, eph tyrosine kinase 3
, ephrin type-B receptor 2
, protein-tyrosine kinase HEK5
, renal carcinoma antigen NY-REN-47
, tyrosine-protein kinase TYRO5
, tyrosine-protein kinase receptor EPH-3
, neural kinase
, nuk receptor tyrosine kinase
, tyrosine-protein kinase receptor SEK-3
, embryo kinase 5 protein CEK5