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Human SMN2 Protein expressed in Wheat germ - ABIN1320680
Cucchiarini, Madry, Terwilliger: Enhanced expression of the central survival of motor neuron (SMN) protein during the pathogenesis of osteoarthritis. in Journal of cellular and molecular medicine 2013
We have now identified A-44G as an additional positive disease modifier, present in a group of patients carrying 3 SMN2 (zeige SMN1 Proteine) copies. Through systematic mutagenesis, we found that the improvement in exon 7 splicing is mainly attributable to the A-44G transition in intron 6.
Ongoing research may yield other treatments, especially for children who have not responded to Spinraza. A gene therapy delivered by adeno (zeige ADORA2A Proteine)-associated virus type 9 (AAV9) is designed to replace or correct SMN1 (zeige SMN1 Proteine) . Cure SMA (zeige SMN1 Proteine) is supporting research in this area as well as studies of small molecules that correct SMN2 (zeige SMN1 Proteine) splicing or spur it to produce more protein.
To determine the dependence of oligodendrocyte (OL)on the Smn (zeige STMN1 Proteine) protein(SMN1 (zeige SMN1 Proteine)), we utilized the Smn (zeige STMN1 Proteine)-/-;SMN2 (zeige SMN1 Proteine) (severe) mouse model. Our data suggest that despite the multi-functionality and ubiquitous expression of the Smn (zeige STMN1 Proteine) protein, it does not play a key role in myelination of the CNS, at least in the context of spinal muscular atrophy pathogenesis.
The spleen is disproportionately small in the murine model of spinal muscular atrophy with a deficiency in SMN2 (zeige SMN1 Proteine).
Low SMN2 (zeige SMN1 Proteine) expression is associated with Spinal Muscular Atrophy.
we have characterized SMN (zeige STMN1 Proteine)-C1, a low-molecular weight compound that corrects alternative splicing defects of SMN2 (zeige SMN1 Proteine) exon 7. We evaluated SMN (zeige STMN1 Proteine)-C1 pharmacokinetics in mice, the dose-response of SMN (zeige STMN1 Proteine)-C1 induction of SMN (zeige STMN1 Proteine) protein in two mouse models of SMA (zeige SMN1 Proteine), the correlation between SMN (zeige STMN1 Proteine)-C1 PK and SMN (zeige STMN1 Proteine) protein induction in vivo, and demonstrated that the peripheral SMN (zeige STMN1 Proteine) protein levels correlated with CNS SMN (zeige STMN1 Proteine) protein levels
Deletion in SMN2 (zeige SMN1 Proteine) gene is associated with spinal muscular atrophy.
Thus, we can conclude that SMN2 (zeige SMN1 Proteine) methylation may regulate the SMA (zeige SMN1 Proteine) disease phenotype by modulating its transcription.
This study demonstrated that Deficiency of the Survival of SMN2 (zeige SMN1 Proteine) Impairs mRNA Localization and Local Translation in the Growth Cone of Motor Neurons
Inverse correlation was observed between SMN2 (zeige SMN1 Proteine), SERF1A and NAIP (zeige NAIP Proteine) copy number polymorphism and spinal muscular atrophy type.
This gene is part of a 500 kb inverted duplication on chromosome 5q13. This duplicated region contains at least four genes and repetitive elements which make it prone to rearrangements and deletions. The repetitiveness and complexity of the sequence have also caused difficulty in determining the organization of this genomic region. The telomeric and centromeric copies of this gene are nearly identical and encode the same protein. While mutations in the telomeric copy are associated with spinal muscular atrophy, mutations in this gene, the centromeric copy, do not lead to disease. This gene may be a modifier of disease caused by mutation in the telomeric copy. The critical sequence difference between the two genes is a single nucleotide in exon 7, which is thought to be an exon splice enhancer. Note that the nine exons of both the telomeric and centromeric copies are designated historically as exon 1, 2a, 2b, and 3-8. It is thought that gene conversion events may involve the two genes, leading to varying copy numbers of each gene. The full length protein encoded by this gene localizes to both the cytoplasm and the nucleus. Within the nucleus, the protein localizes to subnuclear bodies called gems which are found near coiled bodies containing high concentrations of small ribonucleoproteins (snRNPs). This protein forms heteromeric complexes with proteins such as SIP1 and GEMIN4, and also interacts with several proteins known to be involved in the biogenesis of snRNPs, such as hnRNP U protein and the small nucleolar RNA binding protein. Four transcript variants encoding distinct isoforms have been described.
component of gems 1
, survival motor neuron protein
, tudor domain containing 16B
, survival of motor neuron 2, centromeric