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Human Polyclonal PRODH Primary Antibody für IHC (p), IHC - ABIN251304
Paterlini, Zakharenko, Lai, Qin, Zhang, Mukai, Westphal, Olivier, Sulzer, Pavlidis, Siegelbaum, Karayiorgou, Gogos: Transcriptional and behavioral interaction between 22q11.2 orthologs modulates schizophrenia-related phenotypes in mice. in Nature neuroscience 2005
Human Polyclonal PRODH Primary Antibody für ELISA, WB - ABIN4347384
Li, Ma, Hu, Wang, Yan, Meng, Liu, Toulopoulou, Murray, Collier: PRODH gene is associated with executive function in schizophrenic families. in American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2008
Human Polyclonal PRODH Primary Antibody für FACS, IHC (p) - ABIN1881685
Polyak, Xia, Zweier, Kinzler, Vogelstein: A model for p53-induced apoptosis. in Nature 1997
knockdown and overexpression of human PRODH and slgA in the lateral neurons ventral (LNv (zeige CMTM7 Antikörper)) lead to altered aggressive behavior.
ARR18 interaction negatively interferes with the transcriptional activity of bZIP63 on the PDH1 promoter. [PDH1]
ProDH potentiates the oxidative burst and cell death associated with the hypersensitive response.
ProDH-silenced plants displayed reduced ROS (zeige ROS1 Antikörper) and cell death levels as well as enhanced susceptibility in response to avirulent pathogens.
bZIP11 target processes are identified using transiently increased nuclear bZIP11 levels and genome-wide expression analysis; the effect of bZIP11 on ASN1 (zeige ASNS Antikörper) and GBF6 are reported.
Here, we show that Prodh-deficient mice with elevated CNS L-proline display specific deficits in high-frequency GABA-ergic transmission and gamma-band oscillations. We find that L-proline is a GABA-mimetic and can act at multiple GABA-ergic targets
PRODH/POX and succinate regulated mitochondrial respiration.
PRODH/POX knockdown decreased DNA and collagen biosynthesis, whereas increased prolidase (zeige PEPD Antikörper) activity and intracellular proline level in MCF-7shPRODH/POX cells.
this study shows that PRODH plays a causative role in DNA damage-induced senescence through the enzymatic generation of reactive oxygen species
the frequency of a recurrent small 22q11.2 deletion encompassing PRODH and the neighboring DGCR6 (zeige DGCR6 Antikörper) gene in three case-control studies, was studied.
The findings support a major role for the PRODH 757TT, 1766GG, and 1852AA genotypes alone and in combination for schizophrenia susceptibility.
Thirty-five percent of the subjects were hyperprolinemic, allele carriers of PRODH rs450046 had a lower full-scale intelligence compared to T allele carriers
GR and KLF15 physically interact via low affinity GR binding sites within glucocorticoid response elements (GREs) for PRODH and AASS that contribute to combinatorial regulation with KLF15.
results suggest that PRODH and COMT may interact to contribute to the ASD phenotype in individuals with VCFS
Functional COMT (zeige COMT Antikörper), but not PRODH, variant affects IQ and executive functions in 22q11.2DS subjects during neurodevelopment with a maximal effect at adulthood
Data indicate that a functional proline dehydrogenase (PRODH) variant associated with schizophrenia that may have a neurochemical impact, altering brain function, but is not responsible for the cortical reductions found in the disorder.
This gene encodes a mitochondrial protein that catalyzes the first step in proline degradation. Mutations in this gene are associated with hyperprolinemia type 1 and susceptibility to schizophrenia 4 (SCZD4). This gene is located on chromosome 22q11.21, a region which has also been associated with the contiguous gene deletion syndromes, DiGeorge and CATCH22. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
proline dehydrogenase (oxidase) 1
, Proline dehydrogenase (Proline oxidase)
, proline dehydrogenase
, proline dehydrogenase, mitochondrial-like
, proline dehydrogenase 1, mitochondrial
, proline dehydrogenase, mitochondrial
, proline oxidase
, p53-induced gene 6 protein
, proline oxidase 2
, proline oxidase, mitochondrial
, tumor protein p53 inducible protein 6
, proline dehydrogenase (proline oxidase)