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Human HPR Protein expressed in Escherichia coli (E. coli) - ABIN1099135
Inamoto, Martin, Paczesny, Tabellini, Momin, Mumaw, Flowers, Lee, Carpenter, Storer, Hanash, Hansen: Association of Plasma CD163 Concentration with De Novo-Onset Chronic Graft-versus-Host Disease. in Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation 2017
the haptoglobin (HP) rs8062041 appeared to be protective against African Trypanosomiasis; HPR is adjacent to HP and is a component of the Trypanolytic factor; the HP and HPR locus is duplicated in some people; the rs8062041 variant may be associated with this duplication and it is possible that increased production of HPR is the cause of protection associated with rs806204
Data indicate that haptoglobin-related protein (Hpr) is presented at the surface of hepG2 cells.
Our analysis illustrates the complex interplay between functions and haplotypes of adjacent genes, environmental context and natural selection, and offers insights into potential use of haptoglobin or haptoglobin-related protein as therapeutic agents.
show that trypanosome lytic factor-1 resistance in Trypanosoma brucei brucei is caused by reduced expression of the Hp/Hb receptor gene.
No trypanosome lytic activity in the sera of mice producing human haptoglobin-related protein
recombinant Hpr binds hemoglobin as efficiently as haptoglobin
apoL-I is responsible for the trypanolytic activity of normal human serum, whereas Hpr allows fast uptake of the carrier HDL particles in trypanolysis
Infection by Trypanosoma brucei brucei causes hemolysis that triggers activation of trypanosome lytic factor by formation of haptoglobin-related protein-hemoglobin complexes, enhancing binding, trypanolytic activity, and clearance of parasites.
at low pH. Trypanosome lytic factor, apoL-1, and apoA-1 exhibit specificity for anionic membranes, whereas Hpr permeabilizes both anionic and zwitterionic membranes.
Elimination of both HPR and PMDH in peroxisomes causes a slight decrease in the rates of photosynthesis under photorespiratory conditions. [HPR1]
The results indicate that HPR can oxidise NADH at sufficient rate in the absence of PMDH to support beta-oxidation and hence seed germination.
This gene encodes a haptoglobin-related protein that binds hemoglobin as efficiently as haptoglobin. Unlike haptoglobin, plasma concentration of this protein is unaffected in patients with sickle cell anemia and extensive intravascular hemolysis, suggesting a difference in binding between haptoglobin-hemoglobin and haptoglobin-related protein-hemoglobin complexes to CD163, the hemoglobin scavenger receptor. This protein may also be a clinically important predictor of recurrence of breast cancer.
, Haptoglobin-related locus