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Human Factor VII Protein expressed in Human Cells - ABIN2004310
Li, Wang, Long, Su, Bukhory, Dai, Jin, Huang, Jia, Li, Fan, Liu, Wang: Novel antibody against a glutamic acid-rich human fibrinogen-like protein 2-derived peptide near Ser91 inhibits hfgl2 prothrombinase activity. in PLoS ONE 2014
Hepsin (zeige HPN Proteine) plays a physiologically important role in factor VII (zeige TH Proteine) activation and hemostasis in zebrafish.
study reports the full-length cDNA sequences of rhesus monkey FVII; deduced protein sequence of FVII indicates the functional domains; comparison of three-dimensional protein structure with human shows high conservation between them
FVIIa-antithrombin (zeige SERPINC1 Proteine) levels in early and late preeclampsia
Using protein C (zeige PROC Proteine)-factor VII (zeige TH Proteine) chimera demonstrate that APC (zeige APC Proteine) light chain amino acid residues outside the EPCR (zeige PROCR Proteine)-binding site enable cytoprotective PAR1 (zeige MARK2 Proteine) signaling.
Report a good correlation between the type of F7 mutation and/or polymorphisms and FVII:C levels, without a direct link between FVII:C and bleeding tendency in factor VII (zeige TH Proteine) deficiencies.
Polymorphism rs6046 of the FVII gene is associated with the development of fetal growth retardation in Central Russia.
A common pathogenic mechanism, possibly a defective folding of the mutant proteins, was triggered by the FVII mutations. The misfolded state led to impaired trafficking of these proteins causing Endoplasmic reticulum retention, which would explain the low to very low FVII plasma levels observed in patients carrying these mutations.
FVIIa-antithrombin (zeige SERPINC1 Proteine) but not FVIIa is a ligand for LRP1 (zeige LRP1 Proteine), and LRP1 (zeige LRP1 Proteine) contributes to the clearance of FVIIa-antithrombin (zeige SERPINC1 Proteine) in vivo
Data suggest that, for all coagulation proteins tested (prothrombin, factor X, activated factor VII, activated protein C), tighter binding to lipid bilayers (lower Kd) is observed as the proportion of anionic phospholipid increases. These studies were conducted in high-throughput screening using phospholipid bilayers in nanodiscs with multiplexed silicon photonic sensor (micro-ring resonator) array technology.
A coagulation initiating pathway is revealed in which the TF-FVIIa-nascent FXa (zeige F10 Proteine) complex activates FVIII (zeige F8 Proteine) apart from thrombin (zeige F2 Proteine) feedback.
Data suggest activation of PAR2 (zeige F2RL1 Proteine) via FVIIA/TF signaling activates PI3K (zeige PIK3CA Proteine)/AKT (zeige AKT1 Proteine) signaling, inactivates GSK3b signaling, leads to accumulation of beta-catenin (zeige CTNNB1 Proteine), and promotes tumor cell migration/invasion. (PAR2 (zeige F2RL1 Proteine) = protease-activated receptor 2 (zeige F2RL1 Proteine); FVIIA = coagulation factor VIIa; TF = tissue factor/thromboplastin (zeige F3 Proteine); PI3K (zeige PIK3CA Proteine) = phosphatidylinositol 3-kinase; AKT (zeige AKT1 Proteine) = proto-oncogene (zeige RAB1A Proteine) protein c (zeige PROC Proteine)-akt (zeige AKT1 Proteine); GSK3b = glycogen synthase kinase 3 beta)
heterozygotes for FVII deficiency show rare bleeding manifestations which are also present in the unaffected family members with normal FVII levels. This indicates that Factor VII (zeige TH Proteine) activity levels played no role in the occurrence of the bleeding symptoms. Furthermore, FVII levels of around 0.40 IU/dl are capable of assuring a normal hemostasis.
Leu8 (zeige SELL Proteine) is crucial for FVIIa-EPCR (zeige PROCR Proteine) binding; this study characterizes its interaction in vivo in mice
FVIIa binding to EPCR (zeige PROCR Proteine) leads to a barrier protective effect in vivo
FVIIa binding to EPCR (zeige PROCR Proteine) on the endothelium facilitates the transport of FVIIa from circulation to extravascular tissues where TF resides
RNA interference of Serpinc1 (zeige SERPINC1 Proteine) and/or Proc allows for evaluation of the function of these genes in vivo and provides a novel, controlled mouse model for spontaneous venous thrombosis.
Murine FVIIa binds poorly to murine EPCR (zeige PROCR Proteine).
Conclude that the fVII-targeted verteporfin photodynamic therapy that we report here is a novel and effective therapeutic with improved selectivity for the treatment of breast cancer.
The participation of Egr-1 (zeige EGR1 Proteine) in FVIIa-mediated regulation of keratinocyte function was confirmed by use of Egr-1 (zeige EGR1 Proteine)-deficient mice, wherein a significant delay in skin wound healing after injury was observed, relative to WT mice.
Recombinant FVIIa readily associates with the vascular endothelium and subsequently enters into extravascular spaces where it is likely to bind to tissue factor (zeige F3 Proteine) and is retained for extended time periods.
Gene targeting of tissue factor (zeige F3 Proteine), factor X, and factor VII (zeige TH Proteine) in mice: their involvement in embryonic development
This gene encodes coagulation factor VII which is a vitamin K-dependent factor essential for hemostasis. This factor circulates in the blood in a zymogen form, and is converted to an active form by either factor IXa, factor Xa, factor XIIa, or thrombin by minor proteolysis. Upon activation of the factor VII, a heavy chain containing a catalytic domain and a light chain containing 2 EGF-like domains are generated, and two chains are held together by a disulfide bond. In the presence of factor III and calcium ions, the activated factor then further activates the coagulation cascade by converting factor IX to factor IXa and/or factor X to factor Xa. Defects in this gene can cause coagulopathy. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
coagulation factor VII
, serum prothrombin conversion accelerator
, clotting factor
, FVII coagulation protein
, eptacog alfa
, anti-thrombin 3
, serine (or cysteine) proteinase inhibitor, clade C (antithrombin), member 1
, serpin C1
, serpin peptidase inhibitor, clade C, member 1