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Data show that S100 calcium binding protein A6 (S100A6 (zeige S100A6 Proteine)) is required for the Ca2 (zeige CA2 Proteine)+-dependent nuclear translocation of calcyclin binding protein (CacyBP/SIP) in colon cancer SW480 cells.
CacyBP/SIP nuclear localization, dependent on S100 protein, suppresses gastric cancer tumorigenesis through beta-catenin (zeige CTNNB1 Proteine) degradation and the dephosphorylation of ERK1/2 during the G2 phase.
Our data have shown for the first time the regulation of CacyBP/SIP gene expression by NFAT1 (zeige NFAT1 Proteine). Since NFAT (zeige NFATC1 Proteine) transcription factors are involved in processes related to immune response, these results indicate potential involvement of CacyBP/SIP in the immune system.
These results suggest that CacyBP/SIP may be promoting growth of colon cancer cells by enhancing ubiquitin-mediated degradation of p27kip1 (zeige CDKN1B Proteine).
The biological characteristics a (zeige SIAH1 Proteine)nd target proteins of CacyBP/SIP and its exact role in various cancers are discussed. Re (zeige S100A6 Proteine)view.
CacyBP/SIP nuclear translocation contributes to the proliferation of gastric cancer cells, and CacyBP/SIP exerts this effect, at least in part, by stimulating ubiquitin-mediated degradation of p27Kip1 (zeige CDKN1B Proteine).
CacyBP/SIP plays an important role in inhibiting apoptosis of glioma cells which might be mediated by ERK1/2 signaling pathway.
CacyBP/SIP is a useful indicator of dis processes in Chronic Lymphocytic Leukemia (CLL) and plays an important role in sustaining the balance of cell proliferation and apoptosis.
CacyBP/SIP nuclear translocation promotes the proliferation and cell cycle progression of gastric cancer cells.
Overexpression of CacyBP is associated with glioma.
involvement of CacyBP/SIP in the regulation of p38 (zeige CRK Proteine) kinase activity, in addition to that of ERK1/2, might point to the function of CacyBP/SIP in pro-survival and pro-apoptotic pathways.
In undifferentiated and differentiated tumor cells, CacyBP level has an effect on the ERK1/2-CREB (zeige CREB1 Proteine)-BDNF (zeige BDNF Proteine) pathway.
Calcyclin-binding protein/Siah-1 (zeige SIAH1 Proteine)-interacting protein (CacyBP/SIP) was initially described as a binding partner of S100A6 (zeige S100A6 Proteine) in the Ehrlich ascites tumor cells and later as a Siah-1 (zeige SIAH1 Proteine)-interacting protein. Its role has been studied in various mouse tumors and cell lines. Review.
sumoylated CacyBP/SIP is present in the cytoplasmic and not in the nuclear fraction. We have also established that lysine 16 is the residue which undergoes sumoylation in the CacyBP/SIP protein.
different activity of CacyBP/SIP in neuroblastoma (zeige ARHGEF16 Proteine) NB2a and colon cancer HCT116 cells might affect the ERK1/2 pathway in the differentiation or proliferation processes
new insight into the interaction between S100 proteins and CacyBP/SIP
SIP (-/-) embryonic fibroblasts have increased levels of cytosolic p27 (zeige CDKN1B Proteine) and exhibit increased cell motility compared to wild-type cells.
CacyBP/SIP exhibits a phosphatase activity toward ERK1/2 kinases while its E217K (zeige Ube2g1 Proteine) mutant does not.
Cacybp is associated with acute lung injury
Data indicated that CacyBP/SIP could simultaneously interact with tubulin (zeige TUBB Proteine) and actin, suggesting that CacyBP/SIP might link actin and tubulin (zeige TUBB Proteine) cytoskeletons.
The protein encoded by this gene is a calcyclin binding protein. It may be involved in calcium-dependent ubiquitination and subsequent proteosomal degradation of target proteins. It probably serves as a molecular bridge in ubiquitin E3 complexes and participates in the ubiquitin-mediated degradation of beta-catenin. Two alternatively spliced transcript variants encoding different isoforms have been found for this gene.
, calcyclin binding protein
, Calcyclin binding protein
, S100A6-binding protein
, Siah-interacting protein (SIP)
, growth-inhibiting gene 5 protein
, siah-interacting protein