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MIF was found to be essential for axis formation and neural development of Xenopus embryos.
Data show that the mif pathway is required for both sensory hair cell (HC) and sensory neuronal cell survival in the ear, for HC differentiation, semicircular canal formation, statoacoustic ganglion (SAG (zeige SAG Proteine)) development, and lateral line HC differentiation.
MIF knockdown significantly accentuates hearing loss in young mice.
Mif mediates PAR4 (zeige F2RL3 Proteine)-induced bladder pain through urothelial HMGB1 (zeige HMGB1 Proteine).
These results show although high systemic levels of MIF contribute to the development of type 2 diabetes mellitus pathology.
High MIF expression is associated with progressive multiple sclerosis.
The lack of MIF leads to disturbances of systemic and hippocampal insulin (zeige INS Proteine) sensitivity, which are possibly responsible for memory deficits and anxiety, most likely through decreased PSA (zeige NPEPPS Proteine)-NCAM (zeige NCAM1 Proteine)-mediated neuroplasticity rather than through neurotrophic factors.
These data indicate the functional role of the MIF-COX (zeige CPOX Proteine)-p53 (zeige TP53 Proteine) axis in inflammation and cancer at the genomic and proteomic levels in COX-2-ablated cells.
Our results showed that MIF regulates MCP-1 (zeige CPT1B Proteine) expression in hepatocytes of injured liver via CD74 (zeige CD74 Proteine), CD44 (zeige CD44 Proteine), and p38 MAPK (zeige MAPK14 Proteine) in an autocrine manner.
MIF is involved in the pathogenesis of AF, probably by down-regulating the protein and gene expression of Cx43 via ERK1/2 kinase activation
Endogenous MIF reduces the accumulation and toxicity of misfolded SOD1 (zeige SOD1 Proteine) in a mouse model of amyotrophic lateral sclerosis.
Gene expression of MIF was 30-fold higher in the heart, compared to skeletal muscle and protein expression of MIF was 3-fold higher in the heart compared to skeletal muscle.
meta-analyses revealed significantly higher circulating MIF (zeige AMH Proteine) levels in patients with rheumatoid arthritis, and found evidence of associations between the MIF (zeige AMH Proteine)-173 C/G and -794CATT5-8 polymorphisms and rheumatoid arthritis susceptibility
MIF (zeige AMH Proteine) -794 CATT genotypes 7/8 and allele CATT 8 were highly associated with pulmonary tuberculosis in a southwestern China population.
Results found MIF and TNFA mRNA expression increased in psoriatic arthritis (PsA) patients with high activity in relation to patients with moderate activity. These results suggest that both mRNA possibly have a role in the progress of the disease severity.
The present study indicated that the MIF (zeige AMH Proteine)-173G/C polymorphism may contribute to the development of pulmonary tuberculosis. Furthermore, significantly higher serum MIF (zeige AMH Proteine) levels were observed in pulmonary tuberculosis patients than in controls, which further indicated that the MIF (zeige AMH Proteine) may play an important role in pulmonary tuberculosis progression, particularly in Asians.
MIF (zeige AMH Proteine) and IL-6 (zeige IL6 Proteine) play important roles in the inflammation associated with polymyositis.
The expression collagen type 3, alpha1 (Col3A1 (zeige COL3A1 Proteine)), matrix metalloproteinase (MMP)2 (zeige MMP2 Proteine)/-9 and transforming growth factor (TGF)beta (zeige TGFB1 Proteine) was higher in patients with permanent atrial fibrillation (AF), compared with patients in sinus rhythm (SR), and the expression levels of MIF (zeige AMH Proteine) were also increased in AF. MIF (zeige AMH Proteine) was involved in the structural remodeling that accompanies AF, possibly by promoting the proliferation of cardiac fibroblasts.
the findings of the present study demonstrated that MIF (zeige AMH Proteine) is a key component in lung cancer progression through promoting the Warburg effect, and that the novel MIF (zeige AMH Proteine)/NFkappaB (zeige NFKB1 Proteine)/HIF1alpha (zeige HIF1A Proteine) axis may prove to be useful for the development of new strategies for treating patients with lung cancer
These results potentially support an effect of MIF, but not Type I IFN, in heightened systemic lupus erythematosus disease severity in Asian systemic lupus erythematosus. The associations of MIF and Asian ethnicity with PAD are at least partly independent
High MIF (zeige AMH Proteine) expression is associated with progressive multiple sclerosis.
Increased perioperative MIF (zeige AMH Proteine)-levels are related to an increased risk of adverse outcome in complex aortic surgery and may represent a biomarker for risk stratification in complex aortic surgery.
In conclusion, the bovine ampulla and isthmus have higher MIF expression during the postovulatory phase.
plasma MIF concentrations may increase with age in months and parity, but do not change either before and after parturition or before and after postpartum first ovulation in Japanese black cows
Data suggest that, in obese cows, expression of MIF is suppressed in the ampulla and isthmus of Fallopian tubes as compared to normal-weight cows; however, MIF expression is also lower in Fallopian tubes of lean cows. The primary site of MIF expression in Fallopian tube ampulla/isthmus is the tunica mucosa. These studies were conducted in Japanese Black calves.
The objective of the present study was to determine if SNPs in 5' region of bovine MIF affects its promoter activity.
MIF plays a role in early embryo development, and further characterization of MIF expression and its regulation in the endometrium will add significantly to our understanding of early embryo-uterine interactions
The diverse actions of MIF within the immuno-neuroendocrine system may be a result of its occurrence in different isoforms and oligomerization states.
The purification of macrophage migration inhibitory factor (MIF) from bovine brain cytosol and its partial characterization are reported.
Transcription of MIF is induced by activation of PPARgamma2 (zeige PPARG Proteine) and inhibited by excessive resistin (zeige RETN Proteine).
The high activity of MIF in the maternal and fetal tissues throughout placentation and its expression in the nonpregnant uterus indicate a regulatory role for MIF during embryo receptivity and epitheliochorial placentation
This gene encodes a lymphokine involved in cell-mediated immunity, immunoregulation, and inflammation. It plays a role in the regulation of macrophage function in host defense through the suppression of anti-inflammatory effects of glucocorticoids. This lymphokine and the JAB1 protein form a complex in the cytosol near the peripheral plasma membrane, which may indicate an additional role in integrin signaling pathways.
, L-dopachrome tautomerase
, Phenylpyruvate tautomerase
, macrophage migration inhibitory factor
, phenylpyruvate tautomerase
, Macrophage migration inhibitory factor
, delayed early response protein 6
, glycosylation-inhibiting factor
, glutathione-binding 13 kDa protein