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anti-Mouse (Murine) DDIT3 Antikörper:
anti-Rat (Rattus) DDIT3 Antikörper:
anti-Human DDIT3 Antikörper:
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Human Monoclonal DDIT3 Primary Antibody für GS, ICC - ABIN269517
Hull, Zraika, Udayasankar, Aston-Mourney, Subramanian, Kahn: Amyloid formation in human IAPP transgenic mouse islets and pancreas, and human pancreas, is not associated with endoplasmic reticulum stress. in Diabetologia 2009
Show all 17 Pubmed References
Human Polyclonal DDIT3 Primary Antibody für IHC, IHC (p) - ABIN4313145
Nashine, Liu, Kim, Clark, Pang: Role of C/EBP homologous protein in retinal ganglion cell death after ischemia/reperfusion injury. in Investigative ophthalmology & visual science 2015
Show all 8 Pubmed References
Human Polyclonal DDIT3 Primary Antibody für ELISA, ICC - ABIN6260817
Zhao, Liu, Wang, Dai, Cheng, Cheng, Chen, Zhang, Chen: In vitro additive antitumor effects of dimethoxycurcumin and 5-fluorouracil in colon cancer cells. in Cancer medicine 2018
Show all 5 Pubmed References
Human Polyclonal DDIT3 Primary Antibody für ELISA, ICC - ABIN6260816
Yang, Teng, Li, Xue, Guo, Xiao, Wu: Hydrogen Sulfide Improves Vascular Calcification in Rats by Inhibiting Endoplasmic Reticulum Stress. in Oxidative medicine and cellular longevity 2016
Show all 4 Pubmed References
Human Polyclonal DDIT3 Primary Antibody für IF (p), IHC (p) - ABIN685447
Du, Zhou, Jia, Huang: SelK is a novel ER stress-regulated protein and protects HepG2 cells from ER stress agent-induced apoptosis. in Archives of biochemistry and biophysics 2010
Show all 2 Pubmed References
Mouse (Murine) Monoclonal DDIT3 Primary Antibody für IP, WB - ABIN2668558
Wang, Kuroda, Sok, Batchvarova, Kimmel, Chung, Zinszner, Ron: Identification of novel stress-induced genes downstream of chop. in The EMBO journal 1998
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Human Polyclonal DDIT3 Primary Antibody für ELISA, WB - ABIN560585
Hong, Kim, Kim, Lee, Shin, Son, Han, Sung, Kwon: Apoptosis induction of 2'-hydroxycinnamaldehyde as a proteasome inhibitor is associated with ER stress and mitochondrial perturbation in cancer cells. in Biochemical pharmacology 2007
Human Monoclonal DDIT3 Primary Antibody für ELISA, WB - ABIN560586
Kemmner, Kessel, Sanchez-Ruderisch, Möller, Hinderlich, Schlag, Detjen: Loss of UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase (GNE) induces apoptotic processes in pancreatic carcinoma cells. in FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2012
Human Polyclonal DDIT3 Primary Antibody für IP, IHC - ABIN223141
Zenkel, Kruse, Naumann, Schlötzer-Schrehardt: Impaired cytoprotective mechanisms in eyes with pseudoexfoliation syndrome/glaucoma. in Investigative ophthalmology & visual science 2007
Human Polyclonal DDIT3 Primary Antibody für ELISA, ICC - ABIN6260815
Tian, Liu, Yu, Yang, Feng: Ghrelin ameliorates acute lung injury induced by oleic acid via inhibition of endoplasmic reticulum stress. in Life sciences 2018
Liver ischemia reperfusion injury induces CHOP expression, and CHOP deficiency attenuates liver IRI by inhibiting apoptosis.
Study indicates that CHOP deficiency protects against Western diet-induced AoV calcification in Apoe (zeige APOE Antikörper)(-/-) mice. CHOP deficiency prevents oxLDL-induced VIC (zeige EDN2 Antikörper) osteoblastic differentiation via preventing VIC (zeige EDN2 Antikörper)-derived ABs releasing.
these results suggest that CHOP plays a critical role in the progression of kidney fibrosis, likely through regulation of autophagy and apoptosis.
Atg7 (zeige ATG7 Antikörper) ablation mainly induced the PERK (zeige EIF2AK3 Antikörper)-ATF4 (zeige ATF4 Antikörper)-CHOP axis of the endoplasmic reticulum (ER) stress response in growth plate chondrocytes.
These results suggest JUN (zeige JUN Antikörper) and DDIT3 are independently regulated pro-death signaling molecules in retinal ganglion cells and together account for the vast majority of apoptotic signaling in retinal ganglion cells after axonal injury
We demonstrated that PPARalpha (zeige PPARA Antikörper) activation contributes to liver protection and decreases liver inflammation in acute liver failue (ALF (zeige GTF2A1L Antikörper)), particularly through regulating CHOP. Our findings may provide a rationale for targeting PPARalpha (zeige PPARA Antikörper) as a potential therapeutic strategy to ameliorate ALF (zeige GTF2A1L Antikörper).
This study was undertaken to explore the mechanism whereby ERK5 (zeige MAPK7 Antikörper) inhibition instigates pancreatic beta-cell apoptosis via an endoplasmic reticulum stress-dependent signaling pathway.
ER stress is induced early in EAE and that modulation of ER stress by inhibition of eIF2alpha (zeige EIF2A Antikörper)-CHOP and activation of XBP-1 (zeige XBP1 Antikörper) in RGC specifically, protects RGC somata and axons and preserves visual function.
Constitutive overexpression of the CHOP protein does not induce apoptosis in myelinating glia of the central and peripheral nervous systems
Results identify endoplasmic reticulum stress as an age-dependent modifier of islet survival and function by mechanisms implicating enhancement of CHOP activity and inhibition of the protective activity of p21 (zeige D4S234E Antikörper).
This study demonstrates increased placental expression of HIF-1alpha (zeige HIF1A Antikörper) and CHOP in preeclampsia compared to normotensive pregnancies which correlate to their increased syncytiotrophoblast microvesicles concentration in maternal circulation.
CHOP/GADD153-dependent apoptosis reflects expression of micro-RNA, miR (zeige MLXIP Antikörper)-216b.
These results indicated activation of Unfolded Protein Response (UPR) in different cell types derived from Gaucher disease patients, highlighting the generality of this process in this disease. They also showed that the UPR-regulated CHOP transcription factor induces transcription of the GBA1 (zeige GBA Antikörper) gene.
activation of the IGF-IR/PI3K (zeige PIK3CA Antikörper)/Akt (zeige AKT1 Antikörper) signaling system is a common pattern in MLS which appears to be transcriptionally controlled, at least in part by induction of IGF2 gene transcription in a FUS (zeige FUS Antikörper)-DDIT3-dependent manner.
GRP78 (zeige HSPA5 Antikörper) silencing promoted lung epithelial cell apoptosis during hyperoxia, via regulation of the CHOP pathway.
siRNA silencing of CHOP significantly reduced cyproterone acetate-induced DR5 (zeige TNFRSF10B Antikörper) up-regulation and TRAIL sensitivity in prostate cancer cells. Our study shows a novel effect of cyproterone acetate on apoptosis pathways in prostate cancer cells and raises the possibility that a combination of TRAIL with cyproterone acetate could be a promising strategy for treating castration-resistant prostate cancer
asthmatic patients exhibited aberrant Chop expression along with endoplasmic reticulum stress
GPR4 (zeige GPR4 Antikörper) blockade attenuated renal injury after IR and reduced the cell apoptosis through the suppression of CHOP expression.
Endoplasmic reticulum stress-induced CHOP activation in the brain is a mechanistic link in the palmitate-induced negative regulation of leptin (zeige LEP Antikörper) and IGF1 (zeige IGF1 Antikörper).
CHOP (GADD153) is an inhibitor of Wnt (zeige WNT2 Antikörper)/TCF (zeige HNF4A Antikörper) signals
This gene encodes a member of the CCAAT/enhancer-binding protein (C/EBP) family of transcription factors. The protein functions as a dominant-negative inhibitor by forming heterodimers with other C/EBP members, such as C/EBP and LAP (liver activator protein), and preventing their DNA binding activity. The protein is implicated in adipogenesis and erythropoiesis, is activated by endoplasmic reticulum stress, and promotes apoptosis. Fusion of this gene and FUS on chromosome 16 or EWSR1 on chromosome 22 induced by translocation generates chimeric proteins in myxoid liposarcomas or Ewing sarcoma. Multiple alternatively spliced transcript variants encoding two isoforms with different length have been identified.
C/EBP homoologous protein 10
, C/EBP zeta
, CCAAT/enhancer-binding protein homologous protein
, DNA damage-inducible transcript 3 protein
, c/EBP-homologous protein 10
, growth arrest and DNA-damage-inducible protein GADD153
, C/EBP homologous protein
, growth arrest and DNA damage-inducible protein GADD153
, growth arrest and DNA damage-inducible
, transcription factor GADD153
, C/EBP-homologous protein 10
, DNA-damage inducible transcript 3