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anti-Mouse (Murine) DDIT3 Antikörper:
anti-Rat (Rattus) DDIT3 Antikörper:
anti-Human DDIT3 Antikörper:
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Human Monoclonal DDIT3 Primary Antibody für GS, ICC - ABIN269517
Hull, Zraika, Udayasankar, Aston-Mourney, Subramanian, Kahn: Amyloid formation in human IAPP transgenic mouse islets and pancreas, and human pancreas, is not associated with endoplasmic reticulum stress. in Diabetologia 2009
Show all 17 Pubmed References
Human Polyclonal DDIT3 Primary Antibody für IHC, IHC (p) - ABIN4313145
Nashine, Liu, Kim, Clark, Pang: Role of C/EBP homologous protein in retinal ganglion cell death after ischemia/reperfusion injury. in Investigative ophthalmology & visual science 2015
Show all 8 Pubmed References
Human Polyclonal DDIT3 Primary Antibody für IF (p), IHC (p) - ABIN685447
Du, Zhou, Jia, Huang: SelK is a novel ER stress-regulated protein and protects HepG2 cells from ER stress agent-induced apoptosis. in Archives of biochemistry and biophysics 2010
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Mouse (Murine) Monoclonal DDIT3 Primary Antibody für IP, WB - ABIN2668558
Wang, Kuroda, Sok, Batchvarova, Kimmel, Chung, Zinszner, Ron: Identification of novel stress-induced genes downstream of chop. in The EMBO journal 1998
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Human Polyclonal DDIT3 Primary Antibody für IP, IHC - ABIN223141
Zenkel, Kruse, Naumann, Schlötzer-Schrehardt: Impaired cytoprotective mechanisms in eyes with pseudoexfoliation syndrome/glaucoma. in Investigative ophthalmology & visual science 2007
Human Polyclonal DDIT3 Primary Antibody für ELISA, WB - ABIN560585
Hong, Kim, Kim, Lee, Shin, Son, Han, Sung, Kwon: Apoptosis induction of 2'-hydroxycinnamaldehyde as a proteasome inhibitor is associated with ER stress and mitochondrial perturbation in cancer cells. in Biochemical pharmacology 2007
Human Monoclonal DDIT3 Primary Antibody für ELISA, WB - ABIN560586
Kemmner, Kessel, Sanchez-Ruderisch, Möller, Hinderlich, Schlag, Detjen: Loss of UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase (GNE) induces apoptotic processes in pancreatic carcinoma cells. in FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2012
ER stress is induced early in EAE and that modulation of ER stress by inhibition of eIF2alpha (zeige EIF2A Antikörper)-CHOP and activation of XBP-1 (zeige XBP1 Antikörper) in RGC specifically, protects RGC somata and axons and preserves visual function.
Constitutive overexpression of the CHOP protein does not induce apoptosis in myelinating glia of the central and peripheral nervous systems
Results identify endoplasmic reticulum stress as an age-dependent modifier of islet survival and function by mechanisms implicating enhancement of CHOP activity and inhibition of the protective activity of p21 (zeige D4S234E Antikörper).
Activation of the ER stress execution proteins, PERK (zeige EIF2AK3 Antikörper) and CHOP10, was evaluated to determine whether this process was involved in 15d-PMJ2 cell death. 15d-PMJ2 increased the phosphorylation of PERK (zeige EIF2AK3 Antikörper) and expression of CHOP10 in tumorigenic but not nontumorigenic cells
Chop was found to exacerbate allergic airway inflammation by enhancing M2 programming in macrophages
Our findings support that CHOP may be an important signaling molecule in the progression of chronic kidney disease
GPR4 (zeige GPR4 Antikörper) blockade attenuated renal injury after IR and reduced the cell apoptosis through the suppression of CHOP expression.
CHOP deficiency prevents HFD-induced insulin (zeige INS Antikörper) resistance.
Endoplasmic reticulum stress-induced CHOP activation in the brain is a mechanistic link in the palmitate-induced negative regulation of leptin (zeige LEP Antikörper) and IGF1 (zeige IGF1 Antikörper).
a significant protein-protein interaction between GR and CHOP, (GR-CHOP heterocomplex formation) under endoplasmic reticulum stress conditions, is reported.
siRNA silencing of CHOP significantly reduced cyproterone acetate-induced DR5 (zeige TNFRSF10B Antikörper) up-regulation and TRAIL sensitivity in prostate cancer cells. Our study shows a novel effect of cyproterone acetate on apoptosis pathways in prostate cancer cells and raises the possibility that a combination of TRAIL with cyproterone acetate could be a promising strategy for treating castration-resistant prostate cancer
asthmatic patients exhibited aberrant Chop expression along with endoplasmic reticulum stress
CHOP negatively regulates Polo-like kinase 2 (zeige PLK2 Antikörper) expression via recruiting C/EBPalpha (zeige CEBPA Antikörper) to the upstream-promoter in human osteosarcoma cell line during ER stress
VEGF is an important angiogenic signal required for tissue expansion. We show that VEGFA variation giving allele-specific response to transcription factors with overlapping binding sites associate closely with circulating TSH levels. Because CHOP is induced by several types of intracellular stress, this indicates that cellular stress could be involved in the normal or pathophysiological response of the thyroid to TSH
GRP78 (zeige HSPA5 Antikörper) inhibition enhances ATF4 (zeige ATF4 Antikörper)-induced cell death by the deubiquitination and stabilization of CHOP in human osteosarcoma cells.
These results suggest that Bacteroides fragilis enterotoxin induced accumulation of autophagosomes in endothelial cells, but activation of a signaling pathway involving JNK (zeige MAPK8 Antikörper), AP-1 (zeige FOSB Antikörper), and CHOP may interfere with complete autophagy.
The role of neutrophil elastase (zeige ELANE Antikörper) in the activation of unfolded protein response effector molecules via PERK (zeige EIF2AK3 Antikörper) and CHOP is reported.
CHOP (GADD153) is an inhibitor of Wnt (zeige WNT2 Antikörper)/TCF (zeige HNF4A Antikörper) signals
This gene encodes a member of the CCAAT/enhancer-binding protein (C/EBP) family of transcription factors. The protein functions as a dominant-negative inhibitor by forming heterodimers with other C/EBP members, such as C/EBP and LAP (liver activator protein), and preventing their DNA binding activity. The protein is implicated in adipogenesis and erythropoiesis, is activated by endoplasmic reticulum stress, and promotes apoptosis. Fusion of this gene and FUS on chromosome 16 or EWSR1 on chromosome 22 induced by translocation generates chimeric proteins in myxoid liposarcomas or Ewing sarcoma. Multiple alternatively spliced transcript variants encoding two isoforms with different length have been identified.
C/EBP homoologous protein 10
, C/EBP zeta
, CCAAT/enhancer-binding protein homologous protein
, DNA damage-inducible transcript 3 protein
, c/EBP-homologous protein 10
, growth arrest and DNA-damage-inducible protein GADD153
, C/EBP homologous protein
, growth arrest and DNA damage-inducible protein GADD153
, growth arrest and DNA damage-inducible
, transcription factor GADD153
, C/EBP-homologous protein 10
, DNA-damage inducible transcript 3