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anti-Mouse (Murine) DDIT3 Antikörper:
anti-Rat (Rattus) DDIT3 Antikörper:
anti-Human DDIT3 Antikörper:
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Human Monoclonal DDIT3 Primary Antibody für GS, ICC - ABIN269517
Hull, Zraika, Udayasankar, Aston-Mourney, Subramanian, Kahn: Amyloid formation in human IAPP transgenic mouse islets and pancreas, and human pancreas, is not associated with endoplasmic reticulum stress. in Diabetologia 2009
Show all 15 Pubmed References
Human Polyclonal DDIT3 Primary Antibody für IHC, IHC (p) - ABIN4313145
Nashine, Liu, Kim, Clark, Pang: Role of C/EBP homologous protein in retinal ganglion cell death after ischemia/reperfusion injury. in Investigative ophthalmology & visual science 2015
Show all 6 Pubmed References
Human Polyclonal DDIT3 Primary Antibody für IF (p), IHC (p) - ABIN685447
Du, Zhou, Jia, Huang: SelK is a novel ER stress-regulated protein and protects HepG2 cells from ER stress agent-induced apoptosis. in Archives of biochemistry and biophysics 2010
Show all 2 Pubmed References
Mouse (Murine) Monoclonal DDIT3 Primary Antibody für IP, WB - ABIN2668558
Wang, Kuroda, Sok, Batchvarova, Kimmel, Chung, Zinszner, Ron: Identification of novel stress-induced genes downstream of chop. in The EMBO journal 1998
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Human Polyclonal DDIT3 Primary Antibody für IP, IHC - ABIN223141
Zenkel, Kruse, Naumann, Schlötzer-Schrehardt: Impaired cytoprotective mechanisms in eyes with pseudoexfoliation syndrome/glaucoma. in Investigative ophthalmology & visual science 2007
Human Polyclonal DDIT3 Primary Antibody für ELISA, WB - ABIN560585
Hong, Kim, Kim, Lee, Shin, Son, Han, Sung, Kwon: Apoptosis induction of 2'-hydroxycinnamaldehyde as a proteasome inhibitor is associated with ER stress and mitochondrial perturbation in cancer cells. in Biochemical pharmacology 2007
Human Monoclonal DDIT3 Primary Antibody für ELISA, WB - ABIN560586
Kemmner, Kessel, Sanchez-Ruderisch, Möller, Hinderlich, Schlag, Detjen: Loss of UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase (GNE) induces apoptotic processes in pancreatic carcinoma cells. in FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2012
GPR4 (zeige GPR4 Antikörper) blockade attenuated renal injury after IR and reduced the cell apoptosis through the suppression of CHOP expression.
CHOP deficiency prevents HFD-induced insulin (zeige INS Antikörper) resistance.
Endoplasmic reticulum stress-induced CHOP activation in the brain is a mechanistic link in the palmitate-induced negative regulation of leptin (zeige LEP Antikörper) and IGF1 (zeige IGF1 Antikörper).
a significant protein-protein interaction between GR and CHOP, (GR-CHOP heterocomplex formation) under endoplasmic reticulum stress conditions, is reported.
The study shows that FXR (zeige NR1H4 Antikörper)/RXR regulates Chop expression in a mouse model of steatohepatitis, providing novel insights into pathogenesis of this disorder.
Ddit3 suppresses the differentiation of ATDC5 cells
Free CNPY2 (zeige CNPY2 Antikörper) then engages protein kinase (zeige CDK7 Antikörper) R-like endoplasmic reticulum kinase (PERK (zeige EIF2AK3 Antikörper)) to induce expression of the transcription factor C/EBP homologous protein (CHOP), thereby initiating the unfolded protein response.
SHP (zeige LAMC1 Antikörper) and REV-ERBalpha (zeige NR1D1 Antikörper) play a critical role in controlling rhythmic CHOP expression in alcoholic fatty liver
ER stress-induced increase in ATF4 (zeige ATF4 Antikörper) and CHOP expression is initiated by an increase in Atf4 (zeige ATF4 Antikörper) and Chop mRNA, which is also dependent upon eIF2alpha (zeige EIF2A Antikörper) phosphorylation.
Upregulating HSF1 (zeige HSF1 Antikörper) relieves the tau toxicity in N2a-TauRD DeltaK280 by reducing CHOP and increasing HSP70 (zeige HSP70 Antikörper) a5 (BiP/GRP78 (zeige HSPA5 Antikörper)). Our work reveals how the bidirectional crosstalk between the two stress response systems promotes early tau pathology and identifies HSF1 (zeige HSF1 Antikörper) being one likely key player in both systems.
CHOP negatively regulates Polo-like kinase 2 (zeige PLK2 Antikörper) expression via recruiting C/EBPalpha (zeige CEBPA Antikörper) to the upstream-promoter in human osteosarcoma cell line during ER stress
VEGF is an important angiogenic signal required for tissue expansion. We show that VEGFA variation giving allele-specific response to transcription factors with overlapping binding sites associate closely with circulating TSH levels. Because CHOP is induced by several types of intracellular stress, this indicates that cellular stress could be involved in the normal or pathophysiological response of the thyroid to TSH
GRP78 (zeige HSPA5 Antikörper) inhibition enhances ATF4 (zeige ATF4 Antikörper)-induced cell death by the deubiquitination and stabilization of CHOP in human osteosarcoma cells.
These results suggest that Bacteroides fragilis enterotoxin induced accumulation of autophagosomes in endothelial cells, but activation of a signaling pathway involving JNK (zeige MAPK8 Antikörper), AP-1 (zeige FOSB Antikörper), and CHOP may interfere with complete autophagy.
The role of neutrophil elastase (zeige ELANE Antikörper) in the activation of unfolded protein response effector molecules via PERK (zeige EIF2AK3 Antikörper) and CHOP is reported.
The PERK (zeige EIF2AK3 Antikörper)-eIF2alpha (zeige EIF2A Antikörper)-ATF4 (zeige ATF4 Antikörper)-CHOP signaling pathway has a critical role in tumor progression during endoplasmic reticulum stress. (Review)
HDL (zeige HSD11B1 Antikörper) isolated from patients with metabolic syndrome induced macrophage apoptosis, oxidative stress, and CHOP upregulation, which were blocked by PBA and DPI (zeige DSP Antikörper). These data indicate that ox-HDL (zeige HSD11B1 Antikörper) may activate ER stress-CHOP-induced apoptotic pathway in macrophages via enhanced oxidative stress and that this pathway may be mediated by TLR4 (zeige TLR4 Antikörper).
CHOP (GADD153) is an inhibitor of Wnt (zeige WNT2 Antikörper)/TCF (zeige HNF4A Antikörper) signals
This gene encodes a member of the CCAAT/enhancer-binding protein (C/EBP) family of transcription factors. The protein functions as a dominant-negative inhibitor by forming heterodimers with other C/EBP members, such as C/EBP and LAP (liver activator protein), and preventing their DNA binding activity. The protein is implicated in adipogenesis and erythropoiesis, is activated by endoplasmic reticulum stress, and promotes apoptosis. Fusion of this gene and FUS on chromosome 16 or EWSR1 on chromosome 22 induced by translocation generates chimeric proteins in myxoid liposarcomas or Ewing sarcoma. Multiple alternatively spliced transcript variants encoding two isoforms with different length have been identified.
C/EBP homoologous protein 10
, C/EBP zeta
, CCAAT/enhancer-binding protein homologous protein
, DNA damage-inducible transcript 3 protein
, c/EBP-homologous protein 10
, growth arrest and DNA-damage-inducible protein GADD153
, C/EBP homologous protein
, growth arrest and DNA damage-inducible protein GADD153
, growth arrest and DNA damage-inducible
, transcription factor GADD153
, C/EBP-homologous protein 10
, DNA-damage inducible transcript 3