Keine Produkte auf Ihrer Vergleichsliste.
Ihr Warenkorb ist leer.
Alle Spezies anzeigen
Weitere Synonyme anzeigen
Wählen Sie die Spezies und Applikation aus
anti-Human BHLHE41 Antikörper:
anti-Mouse (Murine) BHLHE41 Antikörper:
anti-Rat (Rattus) BHLHE41 Antikörper:
Sie gelangen zu unserer vorgefilterten Suche.
Human Polyclonal BHLHE41 Primary Antibody für IHC, IHC (p) - ABIN446884
Inaguma, Riku, Hashimoto, Murakami, Saga, Ikeda, Kasai: GLI1 interferes with the DNA mismatch repair system in pancreatic cancer through BHLHE41-mediated suppression of MLH1. in Cancer research 2013
Show all 2 Pubmed References
Human Monoclonal BHLHE41 Primary Antibody für IF, ELISA - ABIN528943
Lecomte, Meugnier, Euthine, Durand, Freyssenet, Nemoz, Rome, Vidal, Lefai: A new role for sterol regulatory element binding protein 1 transcription factors in the regulation of muscle mass and muscle cell differentiation. in Molecular and cellular biology 2010
Cow (Bovine) Polyclonal BHLHE41 Primary Antibody für WB - ABIN2778014
Blondelle, Shapiro, Domenighetti, Lange: Cullin E3 Ligase Activity Is Required for Myoblast Differentiation. in Journal of molecular biology 2017
The expression of BHLHE41 in clear cell renal cell carcinoma (ccRCC) was significantly increased in microarray datasets, RNA sequencing data, and in fresh ccRCC tissue samples, compared with than their adjacent nontumorous controls. BHLHE41 knockdown reduced cell proliferation and migration of A498 and CAKI1 cells. These observations demonstrated that BHLHE41 could be a biomarker and an oncogene for ccRCC.
Suppression of SHARP1 induces robust apoptosis of human MLL-AF6 Acute Myeloid Leukemia cells.
These results provide evidence that DEC1 and DEC2 have opposite effects on TGFbetainduced epithelialmesenchymal transition in human prostate cancer PC3 cells.
We validated DEC2 gene as a direct target of miR-873 which could reverse the repressive effects of miR-873 on esophageal cancer cell.
Knockdown of DEC2 resulted in a significant (26.7%) reduction of VEGF expression in MIO-M1 cells under hypoxia-mimicking conditions induced by DFO (P < .05). Levels of HIF1alpha protein were also reduced significantly, by 60.2%, in MIO-M1 cells treated with siRNA against the DEC2 gene (P < .05). Moreover, HIF1alpha levels showed a significant (2.5-fold) increase in MIO-M1 cells overexpressing DEC2 (P < .05).
Mutation in DCE2 gene is associated with short sleep behavioral trait.
It has been concluded that the renal cell carcinoma risk allele at 12p12.1 maps to rs7132434, a functional variant in an enhancer that upregulates BHLHE41 expression which, in turn, induces IL-11, a member of the IL-6 cytokine family.
venous levels lower in preeclampsia than in normal pregnancy
The renal cell cancers associated polymorphic HIF-binding site at chromosome 12p12.1 regulates BHLHE41 expression.
Findings suggest that basic helix-loop-helix family, member e41 protein (DEC2) suppresses cell cycle progression of the mesenchymal cells.
DEC1, at least partly, exerted a pro-apoptotic effect, whereas DEC2 exerted an anti-apoptotic effect in paclitaxel-induced apoptosis of human prostate cancer cells.
the present study indicated that SHARP1 acts as a tumor suppressor in thyroid cancer and that its downregulation may contribute to the proliferation, migration and invasion of thyroid cancer cells through mechanisms possibly involving HIF1alpha
Study found that DEC2 was a direct target of miR-138.
DEC2 is aberrantly expressed in rheumatoid arthritis tissue, it is induced by TNFalpha and not only affects the expression of genes belonging to molecular clock but also significantly impacts on the expression of IL-1beta as well as other inflammatory genes.
BHLHE40/41 are promising markers to predict the aggressiveness of each Endometrial Neoplasm case and that molecular targeting strategies involving BHLHE40/41 and SP1 may effectively regulate Endometrial Neoplasm progression.
DEC2 facilitates HIF-1alpha stabilization and promotes HIF-1 activation in osteosarcoma.
DEC2 participates in hypoxia-induced cell proliferation by functioning as a target gene of the PI3K/Akt signaling pathway and regulating the expression of c-Myc.
SHARP1 interacted with HIF-1alpha physically.
Data suggest that SHARP1 plays a critical role in tumorigenesis and acquisition of the metastatic phenotype in endometrial cancer.
DEC2 regulates cellular function by modulating the expression of Twist1
these results suggest that Bhlhe41 plays critical roles in regulating cell death and neurite outgrowth in N2a cells.
Genetic deletion of SHARP1 in mice delays the development of leukemia and attenuated leukemia-initiating potential, while sparing normal hematopoiesis.
Bhlhe41 directly repressed the expression of cell-cycle regulators and inhibitors of BCR signaling while enabling pro-survival cytokine signaling. Thus, Bhlhe41 controls the development, BCR repertoire and self-renewal of B-1a cells.
Data show that the bHLH transcription factors SHARP1 and SHARP2 are involved in cognitive processing by controlling insulin-like growth factor II (Igf2) expression and associated signaling cascades.
abnormal sleep and certain (endo)phenotypes of psychiatric diseases may be caused by common mechanisms involving components of the molecular clock including SHARP1 and SHARP2.
SENP1 enhances adipogenesis through de-SUMOylation of Sharp-1, which then releases Sharp-1 repression of PPARgamma expression and adipocyte differentiation. These results reveal SENP1 as a novel regulator in adipogenesis.
These results demonstrate that Sharp-1 regulates muscle regenerative capacity, at least in part, by modulation of TGF-beta signaling
Data show that G9a, a lysine methyltransferase, is involved in Sharp-1-mediated inhibition of muscle differentiation.
Interactions of Per1/2 and Dec2 in the regulation of period, phase, and rhythm sustainment are cell-type specific.
RORalpha suppresses adipogenic differentiation at a later stage of differentiation by RORE-mediated stimulation of Dec1 and Dec2 expression.
Results suggest a partially redundant and bidirectional regulatory function for Dec1/2 genes in transcriptional translational feedback loops and conservation of Per1-Dec synergism between vertebrate and invertebrate clocks.
measured circadian locomotor behavior and clock gene expression in the SCN of Per2/Dec1/2 double- and triple-mutant mice to analyze the functional interaction of PER2 and DEC1/2 feedback on circadian pacemaker function in the SCN
Studies identify a novel function for Sharp-1 in cell cycle arrest and DNA damage-induced apoptosis. Inappropriate Sharp-1 expression may therefore be associated with tumorigenesis.
mSharp-1 may regulate the differentiation of several cell types during vertebrate development
Dec1 and Dec2 are regulators of the mammalian molecular clock, and form a fifth clock-gene family.
functions as a transcriptional repressor of E box activity and Stra13 expression
Dec1 and Dec2 are upregulated by clock protein
interference with MyoD function underlies Sharp-1-mediated repression of myogenic differentiation
Marked changes in the Dec1 and Dec2 expression suggest that CLOCK plays a major role in the expression of these genes in most tissues.
This gene encodes a transcription factor that belongs to the Hairy/Enhancer of Split subfamily of basic helix-loop-helix factors. The encoded protein functions as a transcriptional repressor and as a regulator of molecular clock. Defects in this gene are associated with the short sleep phenotype.
basic helix-loop-helix domain containing, class B, 3
, basic helix-loop-helix family, member e41
, class E basic helix-loop-helix protein 41
, differentially expressed in chondrocytes protein 2
, enhancer-of-split and hairy-related protein 1
, bHLH transcriptional factor Dec2
, basic helix-loop-helix domain containing, class B3
, class B basic helix-loop-helix protein 3