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A hierarchic gene expression of copper homeostatic genes was demonstrated between atp7a (zeige ATP7A Proteine), sp1 and sod1 (zeige SOD1 Proteine) in zebrafish.
zebrafish Sp1-like protein is structurally and functionally comparable to human Sp1
we proposed a model to link FXR (zeige NR1H4 Proteine) to Sp1 (zeige PSG1 Proteine), which included triggered FXR (zeige NR1H4 Proteine), p38/MAPK (zeige MAPK14 Proteine) and/or PI3K (zeige PIK3CA Proteine)/AKT (zeige AKT1 Proteine) signaling and phosphorylated Sp1 (zeige PSG1 Proteine), to illustrate the potential crosstalk between the two factors.
Results found that Sp1 (zeige PSG1 Proteine) could activate miR (zeige MLXIP Proteine)-205 expression by binding to its promoter region in response to ionizing radiation in esophageal squamous cell carcinoma.
miR (zeige MLXIP Proteine)-29c suppressed MGMT (zeige MGMT Proteine) expression indirectly via targeting specificity protein 1
miR (zeige MLXIP Proteine)-29c overexpression could abrogate the tumor progression and inhibit the Sp1 (zeige PSG1 Proteine)/TGF-beta (zeige TGFB1 Proteine) expressions in vivo, indicating that miR (zeige MLXIP Proteine)-29c could be a tumor suppressor and repress the Sp1 (zeige PSG1 Proteine)/TGF-beta (zeige TGFB1 Proteine) axis-induced EMT (zeige ITK Proteine) in lung cancer.
Simultaneous high expression of PLD1 and Sp1 (zeige PSG1 Proteine) predicts a poor prognosis for pancreatic ductal adenocarcinoma patients.
Specificity protein 1 (Sp1) orchestrates the transcription of both VEGF (zeige VEGFA Proteine) and VEGFR2 (zeige KDR Proteine); hence, Sp1 (zeige PSG1 Proteine) could act as a therapeutic target. Here, we demonstrate that CF3DODA-Me induced apoptosis, degraded Sp1 (zeige PSG1 Proteine), inhibited the expression of multiple drivers of the blebbishield emergency program such as VEGFR2 (zeige KDR Proteine), p70S6K (zeige RPS6KB1 Proteine), and N-Myc (zeige MYCN Proteine) through activation of caspase-3 (zeige CASP3 Proteine), inhibited reactive oxygen species; and inhibited K-Ras (zeige HRAS Proteine) activation to abolis
MBD1 (zeige DPEP1 Proteine) may be a tumor suppressor gene in advanced colorectal cancer (CRC (zeige CALR Proteine))and affect the development and metastasis of CRC (zeige CALR Proteine) by regulating 8 tumor suppressor genes through binding with SP1 (zeige PSG1 Proteine).
our results demonstrate that Sp1 (zeige PSG1 Proteine) positively regulates the basal transcription of FGF21 (zeige FGF21 Proteine) in the liver and adipose tissue and contributes to the obesity-induced FGF21 (zeige FGF21 Proteine) upregulation in mouse adipose tissue and hepatic FGF21 (zeige FGF21 Proteine) upregulation in hepatocarcinogenesis.
The variant lies in a novel binding-site for the transcription factor Sp1, known to be involved in the regulation of ENG (zeige ENG Proteine) and ACVRL1 (zeige ACVRL1 Proteine) transcription.
The results suggest that PLY inhibits osteoblast differentiation by downregulation of Sp1 (zeige PSG1 Proteine) accompanied by induction of autophagy through ROS (zeige ROS1 Proteine)-mediated regulation of the AMPK (zeige PRKAA1 Proteine)/mTOR (zeige FRAP1 Proteine) pathway.
study demonstrates the co-expression of DLX3 (zeige DLX3 Proteine), PPARG (zeige PPARG Proteine) and SP1 in trophoblast binucleated cell (BNC)nuclei; this suggests a possible role of these transcription factors through BNC specific genes at the time of pre-placental differentiation
likely involvement of the Sp family in regulating PTH (zeige PTH Proteine) gene expression through interactions with an Sp1 DNA element in the hormone's promoter.
These results demonstrate that the single nucleotide polymorphism alters the bovine FASN promoter activity in vitro and the Sp1/Sp3 binding ability of the sequence.
The coordinate regulation of the bovine PRNP (zeige PRNP Proteine) promoter suggests the two Sp1 binding site polymorphisms control Sp1 binding to the PRNP (zeige PRNP Proteine) promoter and its activity.
Immunoblotting, qPCR, ChIP and siRNA-mediated gene knockdown studies revealed that the activation of phosphatidylinositol 3-kinase/protein kinase C zeta (zeige PRKCZ Proteine) pathways in poly(I:C)-stimulated cells underlies Sp1 phosphorylation and recruitment to the mCRAMP promoter, leading to enhanced transcription
The Genomic Context and Corecruitment of SP1 Affect ERRalpha Coactivation by PGC-1alpha in Muscle Cells
These results suggest that Sp1 regulates gene expression of AACS (zeige AACS Proteine) in Neuro-2a cells and ketone body utilization affects the balance of histone acetylation.
the results obtained in this study show that Znf179 (zeige RNF112 Proteine) autoregulation through Sp1-dependent mechanism plays an important role in neuroprotection, and NGF (zeige NGFB Proteine)-induced Sp1 signaling may help attenuate more extensive (ROS (zeige ROS1 Proteine)-induced) damage following brain injury
Using MA, we demonstrated Sp1 as a critical stemness-related transcriptional factor protecting GBM cells against stress- and TMZ-induced death. Thus, Sp1 inhibition may prevent recurrence of malignant cells persisting after primary therapy.
Results suggest that 25-hydroxycholesterol (25-HC) induced the interaction between NFATc1 (zeige NFATC1 Proteine) and Sp1, reducing the level of free Sp1 to inhibit microRNA miR (zeige MLXIP Proteine)-139-5p expression and promote osteoclastogenesis.
data indicated that (-)-Epicatechin inhibited AngII-induced cardiac hypertrophy by activating the SP1/SIRT1 (zeige SIRT1 Proteine) signaling pathway.
This resulted in Sp1 displacement from the promoter and binding of Sp3 to it, leading to p300 recruitment and histone acetylation, activating transcription. This is the first study addressing the mechanisms of physiological TLR5 expression in the intestine. Additionally, a novel insight is gained into Sp1/Sp3-mediated gene regulation that may apply to other genes
adrenergic stimulation induced complex formation between Ifrd1 (zeige IFRD1 Proteine), Sp1 and mSIN3B, which is a component of the SIN (zeige POLR3E Proteine) complex containing histone deacetylase (zeige HDAC1 Proteine), in brown adipocytes. These findings, therefore, suggest that Ifrd1 (zeige IFRD1 Proteine) could be a pivotal negative regulator of sympathetic regulation of thermogenic and mitochondrial gene expression in brown adipocytes by interacting with Sp1 and the mSIN3 complex.
Dp71 (zeige DMD Proteine) expression in hepatic cells is carried out, in part, by YY1 (zeige YY1 Proteine)-, Sp1- and Sp3-mediated transcription from the Dp71 (zeige DMD Proteine) promoter.
The protein encoded by this gene is a zinc finger transcription factor that binds to GC-rich motifs of many promoters. The encoded protein is involved in many cellular processes, including cell differentiation, cell growth, apoptosis, immune responses, response to DNA damage, and chromatin remodeling. Post-translational modifications such as phosphorylation, acetylation, glycosylation, and proteolytic processing significantly affect the activity of this protein, which can be an activator or a repressor. Three transcript variants encoding different isoforms have been found for this gene.
, transcription factor Sp1
, transcription factor
, Sp1 transcription factor
, transcription factor Sp1-like
, specificity protein 1
, specific protein-1
, trans-acting transcription factor 1