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Human G0S2 Protein expressed in HEK-293 Cells - ABIN2721519
Laurens, Badin, Louche, Mairal, Tavernier, Marette, Tremblay, Weisnagel, Joanisse, Langin, Bourlier, Moro: G0/G1 Switch Gene 2 controls adipose triglyceride lipase activity and lipid metabolism in skeletal muscle. in Molecular metabolism 2016
ER+ breast cancer cells with restored G0S2 expression had a relative increased sensitivity to tamoxifen
G0S2 protein but not mRNA levels were reduced in the adipose tissue of ATGL (zeige PNPLA2 Proteine)-deficient mice, corroborating the involvement of ATGL (zeige PNPLA2 Proteine) in the stabilization of G0S2
G0S2 silencing mediates MYC (zeige MYC Proteine)-induced oncogenesis in other malignancies
G0S2 expression in naive CD8 (zeige CD8A Proteine)(+) T cells decreased immediately after T-cell receptor activation downstream of various signal transduction pathways. G0S2 inhibits energy production by oxidative phosphorylation to fine-tune proliferation in homeostasis.
findings do not rule out the possibility that G0S2 may be playing a role in other forms of leukemia, but clearly show that the commonly used Emu-Myc (zeige MYC Proteine) transgenic is not the correct model to conduct studies on G0s2
G0s2 is a physiological regulator of adiposity and energy metabolism and is a potential target in the treatment of obesity and insulin (zeige INS Proteine) resistance.
Proteasomal degradation of PPAR-gamma (zeige PPARG Proteine) and the reduction of g0s2 content are permissive for prolonged TNF-alpha (zeige TNF Proteine) induced lipolysis.
G0s2 has an important role in adipogenesis and accumulation of triacylglycerol.
Roles for G0S2 were found in lactation, energy balance, and thermogenesis. This study provides a basis for tumor suppressive effects of G0S2 by regulating lipolysis.
fat-specific G0S2 overexpression uncouples adiposity from insulin (zeige INS Proteine) sensitivity and overall metabolic health through inhibiting adipose lipolysis and decreasing circulating fatty acids.
Palmitate can induce lipid accumulation in HepG2 cells by activating C/EBPbeta (zeige CEBPB Proteine)-mediated G0S2 expression.
G0S2 functions as a master regulator of tissue-specific balance of TG storage vs. mobilization, partitioning of metabolic fuels between adipose and liver, and the whole-body adaptive energy response.
PML (zeige PML Proteine)/RARalpha (zeige RARA Proteine) synergizes with C/EBPepsilon (zeige CEBPE Proteine) to reactivate the C/EBPepsilon (zeige CEBPE Proteine) target G0S2, thereby contributing to All-trans retinoic acid -mediated acute promyelocytic leukemia (zeige PML Proteine) differentiation and potentially, clinical remission.
differences in G0S2 expression may explain depot-specific and obesity-associated differences in lipolysis on the molecular level
Data indicate that a tumor suppressor mechanism by which G0/G1 switch gene 2 product (G0S2) directly inhibits activity of a key intracellular adipose triglyceride lipase (ATGL (zeige PNPLA2 Proteine)).
Results indicate that G0S2 acts as a prosurvival molecule in endothelial cells.
Data indicate that the peptide corresponding to residues Lys (zeige LYZ Proteine)-20 to Ala-52 from G0S2 Inhibits ATGL (zeige PNPLA2 Proteine) in the nanomolar range.
reelin (zeige RELN Proteine) expression is altered by Abeta (zeige APP Proteine) leading to impaired reelin (zeige RELN Proteine) signaling.
A new mechanism that controls proliferation in K562 cells, suggesting a possible tumor suppressor function for G0S2 in leukemia cells.
Promotes apoptosis by binding to BCL2, hence preventing the formation of protective BCL2-BAX heterodimers.
G0/G1 switch protein 2
, G0S2-like protein
, putative lymphocyte G0/G1 switch protein 2
, G0/G1 switch regulatory protein 2
, G0/G1 switch gene 2
, putative lymphocyte G0/G1 switch