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GIMAP5 loss-of-function mutation results in T cell def (zeige CD4 Proteine)iciencies.
These data,demonstrating the downregulation of the mRNA and protein expression levels of GIMAP5 and GIMAP6 (zeige GIMAP6 Proteine) in the tumor tissues and blood of patients with HCC (zeige FAM126A Proteine), suggested the involvement of GIMAP5 and GIMAP6 (zeige GIMAP6 Proteine) in the pathogenesis of HCC (zeige FAM126A Proteine), and indicate their possible use as diagnostic markers for HCC (zeige FAM126A Proteine).
gimap5 has a role in maintaining peripheral tolerance and T cell homeostasis in the gut (zeige GUSB Proteine) [review]
Data indicate that overexpression of GTPase (zeige RACGAP1 Proteine) of the immune-associated nucleotide (zeige GIMAP8 Proteine)-binding protein (zeige COASY Proteine) 5 (zeige CAPS Proteine) (GIMAP5) in HEK (zeige EPHA3 Proteine) (human embryonic kidney)-293 cells resulted in increased Ca2 (zeige CA2 Proteine)+ accumulation within the mitochondria.
Notch (zeige NOTCH1 Proteine) signalling protects T-ALL cells from apoptosis by upregulating the expression of GIMAP5.
These data establish Gimap5 as a key regulator of hematopoietic integrity and lymphocyte homeostasis
A significant increase in systemic lupus erythematosus risk associated with the most common GIMAP5 haplotype was found (odds ratio 1.26, 95% CI 1.02 to 1.54, p = 0.0033).
Resutls show that Gimap5 is located in the endoplasmic reticulum, and the endogenous Gimap5 mRNA is up-regulated in activated T-cells.
These data suggest that the GIMAP5 gene is associated with islet autoimmunity in type I diabetes and add to recent findings implicating the same single nucleotide polymorphism in another autoimmune disease.
Data show that IAN5 polymorphisms are associated with susceptibility to Systemic lupus erythematosus and the development of clinical disease manifestations in a strictly Korean population.
Gimap5 is a critical inhibitor of GSK3-beta in the CD4 (zeige CD4 Proteine)+ T cells.
functional Gimap5 is required for optimal signaling through TCR and IL-7R in T cells.
The defects in T-cell cellularity were more severe in mice lacking both Gimap3 and Gimap5.
a novel link between Gimap5 and Foxo (zeige FOXO3 Proteine) expression and provide evidence for a regulatory mechanism that controls Foxo (zeige FOXO3 Proteine) protein expression and may help to maintain immunological tolerance.
Gimap5 is an important stabilizer of mouse hematopoietic progenitor cell survival.
mouse gimap5 is necessary for the survival of peripheral T cells, NK/NKT (zeige CTSL1 Proteine)-cell development, and the maintenance of normal liver function
This gene encodes a protein belonging to the GTP-binding superfamily and to the immuno-associated nucleotide (IAN) subfamily of nucleotide-binding proteins. In humans, the IAN subfamily genes are located in a cluster at 7q36.1. This gene encodes an antiapoptotic protein that functions in T-cell survival. Polymorphisms in this gene are associated with systemic lupus erythematosus. Read-through transcription exists between this gene and the neighboring upstream GIMAP1 (GTPase, IMAP family member 1) gene.
GTPase, IMAP family member 5
, GTPase IMAP family member 5
, immune associated nucleotide 4 like 1
, immunity associated protein 3
, immunity-associated nucleotide 5 protein
, inhibitor of radiation- and OA-induced apoptosis, Irod/Ian5
, immunity-associated nucleotide 4-like 1 protein
, immunity-associated protein 3
, immunity-associated nucleotide 4 protein