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anti-Mouse (Murine) FOXJ1 Antikörper:
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Human Polyclonal FOXJ1 Primary Antibody für IHC, IHC (p) - ABIN4312347
Song, Walentek, Sponer, Klimke, Lee, Dixon, Harland, Wan, Lishko, Lize, Kessel, He: miR-34/449 miRNAs are required for motile ciliogenesis by repressing cp110. in Nature 2014
uncovers unexpected developmental functions of FoxJ1 in cell fate determination of subsets of neural cells and suggests that FoxJ1 is critical for maintaining the stem cell potential of ependymal cells into adulthood
Non stem- and progenitor-like responses of Foxj1+ ependymal cells to injury and stroke remain to be defined and investigated.
Our findings provide clues regarding the role of FOXJ1 as a tumor inducer in bladder cancer and an enhancer in glycolysis. Targeting FOXJ1 could be a potential therapeutic strategy in bladder cancer.
genome-wide expression profiles of undifferentiated E14.5 vs. abundantly ciliated E18.5 micro-dissected airway epithelia as well as Foxj1(+) vs. Foxj1-deficient foetal (E16.5) lungs of the mouse were compared using microarray hybridisation.
p73 drives multiciliogenesis, both through transcriptional activation of a master ciliogenesis transcription factor FoxJ1 and through regulation of multiple genes central to ciliogenesis.
MYB has an early, crucial and conserved role in multiciliogenesis, and it promotes a novel S-like phase in which centriole amplification occurs uncoupled from DNA synthesis, and then drives later steps of multiciliogenesis through induction of Foxj1.
noto and foxj1 have roles in node formation, nodal ciliogenesis and cilia positioning
we found that Ank3 expression is controlled by Foxj1, a transcriptional regulator of multicilia formation.
Dlx2 and FoxJ1 physically interact and synergistically regulate the Dlx2, FoxJ1, and amelogenin promoters
For the first time, our study identifies the time- and region-specific activity of a perinatal progenitor domain that is required for transition and progression of OB neurogenesis from the embryonic-to-postnatal periods.
Data show that floor plate identity and ciliogenesis are unaffected in mouse embryos lacking Foxj1 and we provide evidence that additional transcription factors expressed in the floor plate share overlapping functions with Foxj1.
foxj1 functions in late-stage ciliogenesis to regulate programs promoting basal body docking and axoneme formation in cells previously committed to the ciliated cell phenotype.
role in the regulation of T cell activation and autoreactivity; Foxj1 likely modulates inflammatory reactions and prevents autoimmunity by antagonizing proinflammatory transcriptional activities
Foxj1 regulates basal body anchoring to the cytoskeleton of ciliated pulmonary epithelial cells.
Asymmetric gene expression during left-right axis patterning occurs in Foxj1 knockout mice.
Foxj1 restrains B cell activation and the maturation of humoral responses in vivo.
These results indicate that a random signal of laterality (Foxj1) is dominant over the reversal signal of laterality (Inv).
Temporal Foxj1 and RhoA activity are essential regulatory events for cytoskeletal remodeling during mammalian ciliogenesis.
Murine cytomegalovirus influences Foxj1 expression, ciliogenesis, and mucus plugging in mice with allergic airway disease.
FoxJ1 playes role in in oro-facial morphogenesis.
Downregulation and aberrant localization of FOXJ1 may be crucial characteristics of the allergic nasal mucosa.
Findings demonstrate that increased FOXJ1 contributes to the progression of CRC, which might be associated with the promotion effect of b-catenin nuclear translocation.
In ependymomas and choroid plexus tumours, reduced expression of FOXJ1 and its ciliogenesis programme are markers of poor outcome
Decreased FOXJ1 expression was correlated with clinic stage, lymph node metastasis, and distant metastasis, and lower FOXJ1 expression independently predicted shorter survival time in gastric carcinoma.
Both protein and mRNA levels of ciliogenesis-associated markers CP110, Foxj1, TAp73 were significantly increased in patients with nasal polyps versus those seen in control subjects and were positively correlated with cilia length
By stimulating ciliogenesis with the transcription factor FOXJ1, it may be possible to maintain close to normal cilia length despite the stress of cigarette smoking.
Nanog-mediated cell migration and invasion involved its regulation of E-cadherin and FOXJ1.
FOXJ1 is an important regulator of cilia gene expression during ciliated cell differentiation, with RFX3 as a transcriptional co-activator to FOXJ1.
FOXJ1 was overexpressed in HCCs and associated with histological grade and poor prognosis.
Rer1p depletion reduced ciliary length and function by increasing gamma-secretase complex assembly and activity and, consequently, enhancing Notch signaling as well as reducing Foxj1a expression.
goblet cells formed in response to IL-13 treatment are in part or wholly derived from progenitors that express the ciliated cell marker, FOXJ1
Single nucleotide polymorphisms were identified in FOXJ1 and a significant association was found with allergic rhinitis.
Data propose that in hair cells, a Foxj1b-dependent motile ciliogenic program is altered by the proneural Atoh proteins to promote the differentiation of immotile kinocilia.
foxj1a regulates asymmetric development through dorsal forerunner cells in a cell-autonomous fashion but foxj1b functions indirectly.
Report of the complete amino acid sequence and developmental expression pattern of Xenopus FoxJ1.
Study shows that the cilia that underlie left-right patterning on the Xenopus gastrocoel roof plate (GRP) and zebrafish Kupffer's vesicle are severely shortened or fail to form in Foxj1 morphants.
This gene encodes a member of the forkhead family of transcription factors. Similar genes in zebrafish and mouse have been shown to regulate the transcription of genes that control the production of motile cilia. The mouse ortholog also functions in the determination of left-right asymmetry. Polymorphisms in this gene are associated with systemic lupus erythematosus and allergic rhinitis.
forkhead transcription factor J1
, forkhead box J1
, forkhead box protein J1-like
, forkhead box protein J1
, forkhead box J protein
, HNF-3/forkhead homolog 4
, forkhead-related protein FKHL13
, hepatocyte nuclear factor 3 forkhead homolog 4
, fork head homologue 4
, forkhead transcription factor HFH-4
, forkhead-like 13
, forkhead box protein J1-B
, Forkhead protein 5
, forkhead box protein J1-A
, forkhead protein 5