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PAR2 signaling from endosomes underlies the persistent hyperexcitability of nociceptors that mediates chronic pain of irritable bowel syndrome.
PAR2 plays an important role in the proliferation and metastasis of hepatocellular carcinoma.
PAR2 expression is crucial for TGF-beta1 (zeige TGFB1 Proteine)-induced ERK (zeige EPHB2 Proteine) activation and cell motility. Functional cooperation of PAR2 and TGF-beta1 (zeige TGFB1 Proteine) involves a physical interaction between PAR2 and ALK5 (zeige TGFBR1 Proteine).
Activation of PAR2 inhibits the expression of IL-10 (zeige IL10 Proteine) in B cells, which can be reversed by treating B cells with Bcl2L12 (zeige BCL2L12 Proteine) shRNA-carrying liposomes.
High Expressions of PAR2 is associated with cancer.
activation of PAR2 compromises the vascular endothelial barrier function by suppressing the expression of Ve-cadherin (zeige CDH5 Proteine).
plays a direct role in melanogenesis by increasing stem cell factor (zeige KITLG Proteine) secretion from keratinocytes
Neutrophil elastase (zeige ELANE Proteine) enhances IL-12p40 production by lipopolysaccharide-stimulated macrophages via transactivation of the PAR-2/EGFR (zeige EGFR Proteine)/TLR4 (zeige TLR4 Proteine) signaling pathway
PAR2 is crucial for TGF-beta1 (zeige TGFB1 Proteine)-induced cell motility by its ability to sustain expression of ALK5 (zeige TGFBR1 Proteine). Therapeutically targeting PAR2 may thus be a promising approach in preventing TGF-beta (zeige TGFB1 Proteine)-dependent driven metastatic dissemination in PDAC and possibly other stroma-rich tumour types.
Protease-activated receptor 2 (PAR2) is present in human skin.
PAR2 activation in the prostate may contribute to the development of lower urinary tract dysfunction through proinflammatory as well as profibrotic pathways.
Our data show that PAR2 counterbalanced enhanced contractions to ET-1 (zeige EDN1 Proteine) in aortas from Tsk (zeige FBN1 Proteine) mice. PAR2 could represent a possible target for novel drugs in the treatment of vascular complications in fibrosis.
thrombin (zeige F2 Proteine) is increased in a mouse model of cancer cachexia in a partially interleukin-6 (zeige IL6 Proteine) dependent manner
Data show that activated protein C (zeige PROC Proteine) signals via protease activated receptors PAR2/PAR3 (zeige F2RL2 Proteine) to expand Treg cells, mitigating the disease in mice.
PAR2 plays an important and previously unrecognised anti-apoptotic role in T cell development
thrombin (zeige F2 Proteine) has a role in diet-induced obesity through fibrin-driven inflammation
PAR2 modulation was sufficient to induce islet cell transdifferentiation in the absence of beta-cells.
Our results are suggestive that PAR2 inhibition may play a role in the treatment of diseases with increased inflammatory responses in renal systems
PAR2/GSK3beta is a novel pathway that plays a critical role in the regulation of stem/progenitor cell survival and proliferation in normal colon crypts and colon cancer.
Enhanced FXa (zeige F10 Proteine) and PAR2 exacerbate DN and that both are promising targets for preventing diabetic nephropathy.
PAR1 and PAR2 regulate endothelial NO synthase phosphorylation and activity through G(12/13) and G(q), delineating the signaling pathways by which the proteases act on protease-activated receptors to modulate endothelial functions.
Coagulation factor II (thrombin) receptor-like 1 (F2RL1) is a member of the large family of 7-transmembrane-region receptors that couple to guanosine-nucleotide-binding proteins. F2RL1 is also a member of the protease-activated receptor family. It is activated by trypsin, but not by thrombin. It is activated by proteolytic cleavage of its extracellular amino terminus. The new amino terminus functions as a tethered ligand and activates the receptor. The F2RL1 gene contains two exons and is widely expressed in human tissues. The predicted protein sequence is 83% identical to the mouse receptor sequence.
Proteinase-activated receptor 2
, G-protein coupled receptor 11
, coagulation factor II receptor-like 1
, protease-activated receptor 2
, proteinase-activated receptor 2
, thrombin receptor-like 1
, Protease-activated receptor-2
, proteinase-activated receptor-2
, Proteinase-activated receptor-2 G protein-coupled receptor 11
, Proteinase-activated receptor-2, G protein-coupled receptor 11