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Overexpression of unc-51 like autophagy activating kinase causes elevated autophagy and aggregation of the ER exit sites(ERES), a region of the ER dedicated for the budding of COPII vesicles. Transport of cargo proteins is therefore inhibited and is retained at the ERES.
silencing of HOTAIR decreased drug resistance of Non-Small Cell Lung Cancer cells to Crizotinib through inhibition of autophagy via suppressing phosphorylation of ULK1.
CLDN1 (zeige CLDN1 Proteine) activates autophagy through up-regulation of ULK1 phosphorylation and promotes drug resistance of non-small cell lung cancer cells to cisplatin.
These findings revealed that prosurvival autophagy was one of the mechanisms involved in the resistance acute myeloid leukemia (zeige BCL11A Proteine) (AML (zeige RUNX1 Proteine)) leukemia stem cells to JQ1. Targeting the AMPK (zeige PRKAA1 Proteine)/ULK1 pathway or inhibition of autophagy could be an effective therapeutic strategy for combating resistance to BET inhibitors in AML (zeige RUNX1 Proteine) and other types of cancer
we demonstrate that Ulk1 over-expression in human gastric cancer is pro-survival. Its over-expression is associated with patients' T classification and cancer relapse.
our results show that inhibition of Ulk1 suppresses Non-small cell lung cancer (NSCLC)cell growth and sensitizes NSCLC cells to cisplatin by modulating both autophagy and apoptosis pathways, and that Ulk1 might be a promising target for NSCLC treatment.
review the diverse roles of ULK1, with special focus on its importance to type I IFN signaling, and highlight important future study questions.
ULK1 played a crucial role in ALDH2 (zeige ALDH2 Proteine)-offered protective effect against high glucose exposure-induced cardiomyocyte injury through regulation of autophagy
Lack of mitochondrial DNA impairs chemical hypoxia-induced autophagy in liver tumor cells through reactive oxygen species-AMPK (zeige PRKAA1 Proteine)-ULK1 signaling dysregulation independently of HIF-1A (zeige HIF1A Proteine).
phosphorylation of mATG9 (zeige ATG9A Proteine) at Tyr8 by Src (zeige SRC Proteine) and at Ser14 by ULK1 functionally cooperate to promote interactions between mATG9 (zeige ATG9A Proteine) and the AP1 (zeige FOSB Proteine)/2 complex.
Ampk (zeige PRKAA1 Proteine) is required for exercise-induced phosphorylation of Ulk1.
We created Smcr8 knockout mice and found that Smcr8 mutant cells exhibit impaired autophagy induction, which is similarly observed in C9orf72 (zeige C9ORF72 Proteine) knockdown cells. Mechanistically, SMCR8/C9ORF72 (zeige C9ORF72 Proteine) interacts with the key autophagy initiation ULK1 complex and regulates expression and activity of ULK1
ATG7 (zeige ATG7 Proteine), but not ATG13 (zeige ATG13 Proteine) or ULK1 has a role in functional autophagy in glioblastoma development
ULK1 is a novel substrate of Caspase-3 (zeige CASP3 Proteine) and upregulation of ULK1 drives autophagy initiation in leukemia cells.
Findings indicate that the PPM1D (zeige PPM1D Proteine)-Ulk1 axis plays a pivotal role in genotoxic stress-induced autophagy.
Regulation of endoplasmic reticulum-to-Golgi trafficking by ULK1/2 is essential for cellular homeostasis.
Ulk1-mediated autophagy plays an essential role in mitochondrial remodeling and functional regeneration of skeletal muscle.
ULK1/2 function as a bifurcate-signaling node that sustains glucose metabolic fluxes besides initiation of autophagy in response to nutritional deprivation.
These results demonstrate a novel mechanism by which STAT1 (zeige STAT1 Proteine) negatively regulates ULK1 expression and autophagy.
These results define a key molecular event for the starvation-induced activation of the ATG14-containing PtdIns3K complex by ULK1.
predicted to have similarity to C. elegans serine/threonine kinase UNC-51
unc-51-like kinase 1 (C. elegans)
, serine/threonine-protein kinase ULK1
, unc-51-like kinase 1
, ATG1 autophagy related 1 homolog
, autophagy-related protein 1 homolog
, serine/threonine-protein kinase Unc51.1