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review the diverse roles of ULK1, with special focus on its importance to type I IFN signaling, and highlight important future study questions.
ULK1 played a crucial role in ALDH2 (zeige ALDH2 ELISA Kits)-offered protective effect against high glucose exposure-induced cardiomyocyte injury through regulation of autophagy
Lack of mitochondrial DNA impairs chemical hypoxia-induced autophagy in liver tumor cells through reactive oxygen species-AMPK (zeige PRKAA1 ELISA Kits)-ULK1 signaling dysregulation independently of HIF-1A (zeige HIF1A ELISA Kits).
phosphorylation of mATG9 (zeige ATG9A ELISA Kits) at Tyr8 by Src (zeige SRC ELISA Kits) and at Ser14 by ULK1 functionally cooperate to promote interactions between mATG9 (zeige ATG9A ELISA Kits) and the AP1 (zeige FOSB ELISA Kits)/2 complex.
we found that ATG14 interacted with Ulk1 and LC3, and knock down of Ulk1 prevented the lipidation of LC3 and autophagy in HeLa-ATG14 cells. We also identified a phosphatidylethanolamine (PE) binding region in ATG14, and the addition of Ulk1 to Hela-ATG14 cells decreased the ATG14-PE interaction.
ULK1 has a role in RPS6KB1 (zeige RPS6KB1 ELISA Kits)-NCOR1 (zeige NCOR1 ELISA Kits) repression of NR1H/LXR (zeige NR1H3 ELISA Kits)-mediated Scd1 (zeige SCD ELISA Kits) transcription and augments lipotoxicity in hepatic cells
Data show that ULK1, a protein kinase (zeige CDK7 ELISA Kits) activated at the autophagosome formation site, phosphorylates human ATG4B (zeige ATG4B ELISA Kits) on serine 316.
While focusing on the role of SMCR8 during autophagy initiation, we found that kinase activity and gene expression of ULK1 are increased upon SMCR8 depletion. The latter phenotype involved association of SMCR8 with the ULK1 gene locus.
despite the significant upregulation of mRNA of the essential autophagy initiation gene ULK1, its protein level is rapidly reduced under starvation.
Our findings demonstrate for the first time that miR (zeige MLXIP ELISA Kits)-26a/b can promote apoptosis and sensitize Hepatocellular carcinoma (HCC (zeige FAM126A ELISA Kits)) to chemotherapy via suppressing the expression of autophagy initiator ULK1, and provide the reduction of miR (zeige MLXIP ELISA Kits)-26a/b in HCC (zeige FAM126A ELISA Kits) as a novel mechanism of tumor chemoresistance.
ATG7 (zeige ATG7 ELISA Kits), but not ATG13 (zeige ATG13 ELISA Kits) or ULK1 has a role in functional autophagy in glioblastoma development
ULK1 is a novel substrate of Caspase-3 (zeige CASP3 ELISA Kits) and upregulation of ULK1 drives autophagy initiation in leukemia cells.
Findings indicate that the PPM1D (zeige PPM1D ELISA Kits)-Ulk1 axis plays a pivotal role in genotoxic stress-induced autophagy.
Regulation of endoplasmic reticulum-to-Golgi trafficking by ULK1/2 is essential for cellular homeostasis.
Ulk1-mediated autophagy plays an essential role in mitochondrial remodeling and functional regeneration of skeletal muscle.
ULK1/2 function as a bifurcate-signaling node that sustains glucose metabolic fluxes besides initiation of autophagy in response to nutritional deprivation.
These results demonstrate a novel mechanism by which STAT1 (zeige STAT1 ELISA Kits) negatively regulates ULK1 expression and autophagy.
These results define a key molecular event for the starvation-induced activation of the ATG14-containing PtdIns3K complex by ULK1.
By enhancing PARP1 (zeige PARP1 ELISA Kits) activity, ULK1 contributes to ATP depletion and death of H2O2-treated cells.
MUL1 ubiquitinates ULK1 and regulates selenite-induced mitophagy
predicted to have similarity to C. elegans serine/threonine kinase UNC-51
unc-51-like kinase 1 (C. elegans)
, serine/threonine-protein kinase ULK1
, unc-51-like kinase 1
, ATG1 autophagy related 1 homolog
, autophagy-related protein 1 homolog
, serine/threonine-protein kinase Unc51.1