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Human SMURF1 Protein expressed in Wheat germ - ABIN1320726
Wang, Zhang, Weng, Qiao, Ma, Xiao, Yu, Pan, Sun et al.: Impaired phosphorylation and ubiquitination by p70 S6 kinase (p70S6K) and Smad ubiquitination regulatory factor 1 (Smurf1) promote tribbles homolog 2 (TRIB2) stability and carcinogenic property in ... in The Journal of biological chemistry 2013
Expression of Smurf1 was increased with WHO grade and was consistent with poor prognosis of gliomas.
Smurf1 interacts with and targets Securin (zeige PTTG1 Proteine), an inhibitor of sister-chromatid separation, for poly-ubiquitination and proteasomal degradation.
Smurf1 overexpression decreases USP25 (zeige USP25 Proteine) protein turnover, and the E3 ligase enzymatic activity of Smurf1 is required for USP25 (zeige USP25 Proteine) degradation.
SMURF1 can be potentially used as a clinical biomarker and target for novel treatment of human GC.
Uev1A (zeige UBE2V1 Proteine) appears to be involved in the BMP signaling pathway in which it collaborates with a ubiquitin E3 ligase Smurf1 to promote Smad1 (zeige GARS Proteine) degradation in a Ubc13 (zeige UBE2N Proteine)-independent manner.
High smurf1 expression is associated with neoplasms.
activation of AMPK (zeige PRKAA1 Proteine) upregulated Smad6 (zeige SMAD6 Proteine) and Smurf1 and thereby enhanced their interactions, resulting in its proteosome-dependent degradation of ALK2 (zeige ACRV1 Proteine).
we propose that the PKA-Smurf1-PIPKIgamma pathway has an important role in pulmonary tumorigenesis and imposes substantial clinical impact on development of novel diagnostic markers and therapeutic targets for lung cancer treatment.
SMU (zeige MLXIP Proteine)RF1 is increased in patients with pulmonary arterial hypertension
Data suggest that SMURF1 is required for S phase progression; SMURF1 promotes ubiquitination-dependent degradation of WEE1 (zeige WEE1 Proteine); these functions of SMURF1 appear to be linked and may be important in cell proliferation and tumorigenesis. (SMURF1 = SMAD specific E3 ubiquitin protein ligase 1; WEE1 (zeige WEE1 Proteine) = wee 1 (zeige WEE1 Proteine) homolog [S pombe] protein)
Six2 (zeige SIX2 Proteine) mediates the protective effects of GDNF on damaged DA neurons by regulating Smurf1 expression.
TGF-beta (zeige TGFB1 Proteine) inhibited osteoblastic differentiation by inducing the MAPK-ERK (zeige MAPK1 Proteine) pathway which upregulated the expression of ubiquitin ligase (zeige RNF123 Proteine) SMURF1 and resulted in reduced presence of osteogenic proteins.
demonstration that Smurf1 acts as a brake for integrin activation by controlling Kindlin-2 (zeige FERMT2 Proteine) protein levels, a new mechanism that permits precise modulation of integrin-mediated cellular functions
miR (zeige MLXIP Proteine)-140-5p and SMURF1 are key regulators of disease pathology in pulmonary arterial hypertension
Smurf1 is required for selective autophagy of Mycobacterium tuberculosis and host defense against tuberculosis infection.
Smurf1 regulates glucose metabolism and inhibits osteoblast differentiation. Smurf1 function requires the presence of serine 148 (S148) in Smurf1.
Smurf1 mediates NGF (zeige NGFB Proteine) signaling and ubiquitinates RhoA (zeige RHOA Proteine) in growth cones, regulating the need for local translation and degradation.
Smurf-mediated endocytosis of Patched1 (zeige PTCH1 Proteine) is required in sonic hedgehog (zeige SHH Proteine) signal reception
Inhibition of rhBMP-2-induced ALP (zeige CCL21A Proteine) activity by intracellular delivery of SMURF1 in murine calvarial preosteoblast cells.
Data demonstrate that Smurf1 and Smurf2 (zeige SMURF2 Proteine) have overlapping and distinct functionalities during early frog embryogenesis; collectively, they regulate ectodermal and mesodermal induction and patterning to ensure normal development of Xenopus embryos.
In Xenopus embryos, the BMP pathway is a major physiological target of Smurf1. We propose that in normal development Smurf1 cooperates with secreted BMP antagonists to limit BMP signaling in dorsal ectoderm.
This gene encodes a ubiquitin ligase that is specific for receptor-regulated SMAD proteins in the bone morphogenetic protein (BMP) pathway. This protein plays a key roll in the regulation of cell motility, cell signalling, and cell polarity. Alternative splicing results in multiple transcript variants encoding different isoforms.
Smad ubiquitination regulatory factor 1
, E3 ubiquitin-protein ligase SMURF1
, SMAD specific E3 ubiquitin protein ligase 1
, e3 ubiquitin-protein ligase SMURF1-like
, E3 ubiquitin ligase SMURF1
, SMAD-specific E3 ubiquitin-protein ligase 1
, Smad-specific E3 ubiquitin ligase 1
, SMAD ubiquitination regulatory factor 1