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This study demonstrated that HRH1 (zeige DHX8 Proteine) gene polymorphisms associated with sedation in clozapine-treated patient with schizophrenia.
Human H1 receptors in Chinese hamster ovary cells are apparently down-regulated by a sustained increase in intracellular Ca(2 (zeige CA2 Proteine)+) concentrations with no process of endocytosis and lysosomal/proteasomal degradation of receptors.
Antihistamines displayed similar kinetic signatures on antagonizing histamine-induced beta-arrestin2 (zeige ARRB2 Proteine) recruitment as compared to displacing radioligand binding from the H1R.
Study suggests that both MAPK (zeige MAPK1 Proteine) p44/p42 (zeige PSMC6 Proteine) and PKC (zeige PRRT2 Proteine) pathways appear to be involved in histamine-upregulated matrix metalloproteinase-9 (zeige MMP9 Proteine) release via histamine H1 receptors in astrocytes.
that histamine H1 receptor activation mediates MAPK activation through PLCbeta, Src, PKCdelta and MEK pathway, but does not lead to nuclear relocalization of phospho-ERK (pERK), classically associated with pro-proliferative changes.
Activation of the H1R by its full agonists resulted in a composite potentiating effect. Intriguingly, inactivation of the Gaq (zeige GNAQ Proteine)-PLC (zeige HSPG2 Proteine) pathway by H1R inverse agonists resulted also in a potentiation of GR activity.
HRH1 (zeige DHX8 Proteine)-mediated sensitization of TRPV1 (zeige TRPV1 Proteine) is involved in IBS. Ebastine, an antagonist of HRH1 (zeige DHX8 Proteine), reduced visceral hypersensitivity, symptoms, and abdominal pain in patients with IBS.
HRH1 (zeige DHX8 Proteine)-17 TT and HNMT (zeige HNMT Proteine)-1639 TT genotypes were associated with the allergic asthma phenotype among African-American children and that the ABP (zeige ABP1 Proteine) 4107 GG genotype was associated with nonallergic asthma among white children.
HRH1 (zeige DHX8 Proteine) transcript was significantly down-modulated in multiple sclerose compared with health control.
The relationship between the expression of HRH1 (zeige DHX8 Proteine) and prognosis was found to vary in different types of cancers, even in the same cancer from different databases.
Sympathetic tone changed in H1R-, but not H2R (zeige HRH2 Proteine)- or H3R (zeige HRH3 Proteine)-null mice.
The results of this study suggest that H1R deficiency in mice is associated with pronounced deficits in hippocampus-dependent spatial learning and memory.
histamine receptor H1 and histamine receptor H2 (zeige HRH2 Proteine) reciprocally regulate inflammation in the ligation-induced arteriosclerosis
Histamine demonstrably inhibited ACh (zeige FGFR3 Proteine)-induced sweating in both mice and humans via H1R-mediated signaling.
This study provides a potential mechanism of H1R-mediated signaling and NF-kB pathway crosstalk in allergic inflammationptor
Neuronal damage is significantly increased in H1R knock-out mice following status epilepticus.
Histamine H1 Receptor expression by CD11B (zeige ITGAM Proteine)(+) cells is not required for susceptibility to experimental allergic encephalomyelitis.
histamine signaling through the H1R on dendritic cells is an important early event conditioning the quality of the skin effector immune response.
endothelial H(1)R expression reduces BBB permeability, suggesting that endothelial H(1)R signaling may be important in the maintenance of cerebrovascular integrity
Regulation of sleep/wake states is completely achieved by OX(2)R (zeige HCRTR2 Proteine)-expressing neurones without involving H(1)R-mediated pathways. Maintenance of basal physiological sleep/wake states is fully achieved without both H(1) and OX(1 (zeige NQO1 Proteine)) receptors.
caveolar and cholesterol integrity are indispensable for the proper functionality of the H(1) and 5-HT(2A) receptors through their Rho/ROCK signaling.
Histamine H1 receptor mRNA is detected in horizontal cell perikarya and primary dendrites of retina.
The histaminergic system regulates wakefulness and orexin/hypocretin neuron development via histamine receptor H1.
Histamine is a ubiquitous messenger molecule released from mast cells, enterochromaffin-like cells, and neurons. Its various actions are mediated by histamine receptors H1, H2, H3 and H4. This gene was thought to be intronless until recently. The protein encoded by this gene is an integral membrane protein and belongs to the G protein-coupled receptor superfamily. It mediates the contraction of smooth muscles, the increase in capillary permeability due to contraction of terminal venules, the release of catecholamine from adrenal medulla, and neurotransmission in the central nervous system. Multiple alternatively spliced variants, encoding the same protein, have been identified.
, histamine H(1) receptor
, histamine H1 receptor
, histamine receptor, subclass H1
, Bordetella pertussis induced histamine sensitization
, histamine receptor subtype H1
, histamine receptor H1
, 7 transmembrane receptor