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Human CD31 Protein expressed in HEK-293 Cells - ABIN2181646
Guzzo, Ichikawa, Park, Phillips, Liu, Zhang, Kwon, Miao, Lu, Rehm, Arthos, Cicala, Cohen, Fauci, Kehrl, Lusso: Virion incorporation of integrin α4β7 facilitates HIV-1 infection and intestinal homing. in Science immunology 2017
novel pathway for PECAM-1 regulation
PECAM-1 may not function as a major mechanoreceptor for activation of MAPK (zeige MAPK1 Proteine) and AKT (zeige AKT1 Proteine) in ECs and that there are likely to be other mechanoreceptors in ECs functioning to detect shear stress and trigger intercellular signals.
PECAM-1 and Fyn (zeige FYN Proteine) are essential components of a PECAM-1-based mechanosensory complex in endothelial cells
PECAM-1 plays a role in the early pathogenesis of thrombotic meningoencephalitis.
In primary hip OA, angiogenesis may be induced by a combined mechanism: hypoxia-related VEGF (zeige VEGFA Proteine)-dependent vasculogenesis and endothelial differentiation of the activated pluripotent cells, which are released from the hyperplastic synovial cells layer. An endothelial mesenchymal transition is assumed to be involved in the fibrotic process.
upregulation of sVEGFR-1 with concomitant decline of PECAM-1 and sVEGFR-2 levels in preeclampsia compared to normotensive pregnancies, Irrespective of the HIV status
Increased expression of PECAM-1, ICAM-3 (zeige ICAM3 Proteine), and VCAM-1 (zeige VCAM1 Proteine) in colonic biopsies from patients with inflammatory bowel disease (IBD) in clinical remission is associated with subsequent flares; this suggests that increases in the expression of these proteins may be early events that lead to flares in patients with IBD.
PECAM-1 gene polymorphisms are associated with Kawasaki disease with and without coronary artery lesions in Chinese children.
Our combined data indicate that as HPMECs achieve confluence and CD31 (zeige HBA1 Proteine) ectodomains become homophilically engaged, multiple SFKs are activated to increase tyrosine phosphorylation of p120ctn (zeige CTNND1 Proteine), which in turn, functions as a cross-bridging adaptor molecule that physically couples NEU1 (zeige NEU1 Proteine) to CD31 (zeige HBA1 Proteine), permitting NEU1 (zeige NEU1 Proteine)-mediated desialylation of CD31 (zeige HBA1 Proteine).
Sirt1 (zeige SIRT1 Proteine) expression is associated with CD31 (zeige HBA1 Proteine) expression in endothelial progenitor cells from patients with chronic obstructive pulmonary disease.
we found a significant cumulative contribution of the genetic heterogeneity of glycoproteins Ia and IIIa and platelet-endothelial cell adhesion molecule-1 and P-Selectin (zeige SELP Proteine) genes in the risk of recurrent IVF (zeige SCN5A Proteine)-ET failures. The coexistence of these SNPs was associated with increased IVF (zeige SCN5A Proteine)-ET failure risk and the more polymorphic alleles or genotypes were present the higher the risk of IVF (zeige SCN5A Proteine)-ET failure, especially for younger women
Dimer conformation of soluble PECAM-1
RrgA, binds both polymeric immunoglobulin receptor (pIgR (zeige PIGR Proteine)) and PECAM-1, whereas the choline binding protein PspC binds, but to a lower extent, only pIgR (zeige PIGR Proteine)
this study shows a significant role for CD31 (zeige HBA1 Proteine) during T cell development
findings suggest that PECAM-1 enhances SDF-1 (zeige CXCL12 Proteine)-induced chemotaxis by augmenting and prolonging activation of the PI3K/Akt (zeige AKT1 Proteine)/mTORC1 pathway and Rap1 (zeige TERF2IP Proteine) and that PECAM-1, at least partly, exerts its activity by inhibiting SDF-1 (zeige CXCL12 Proteine)-induced internalization of CXCR4 (zeige CXCR4 Proteine)
The data in this study provide evidence for the differential involvement of PECAM-1-ligand interactions in PECAM-1-dependent motility and the extension of filopodia.
Both the number of lung CD31-CD45 (zeige PTPRC Proteine)-Sca-1+ cells and the expression levels of the Shh (zeige SHH Proteine) signaling pathway were downregulated in the lung tissues of mice with pulmonary emphysema. These cells and Shh (zeige SHH Proteine) signaling pathway are reactivated during acute adenovirus infection.
In FVB/n mice, PECAM functions upstream of CD99 (zeige CD99 Proteine) in leukocyte diapedesis and blocking antibodies against either molecule arrest neutrophils before they traverse the endothelium. However, in C57BL/6 mice, PECAM and CD99 (zeige CD99 Proteine) appear to function at a different step, as the same antibodies arrest leukocyte migration through the endothelial basement membrane.
These studies indicate a role for PECAM-1 in enhancing the inhibitory functions of TGF-beta (zeige TGFB1 Proteine) in T cells
PECAM1 acts upstream of Gab1, promoting Gab1/Akt (zeige AKT1 Proteine)/eNOS (zeige NOS3 Proteine) phosphorylation and activation, thereby confers EC responsiveness to flow.
Radiation-induced stress conditions induce a transient accumulation of granulocytes within the liver by down-regulation/absence of PECAM-1.
CD31 gene transfer is sufficient to recapitulate the cytoprotective mechanisms in CD31(-) pancreatic beta cells, which become resistant to immune-mediated rejection when grafted in fully allogeneic recipients
PECAM1+ melanoma cells form vascular channels
The protein encoded by this gene is found on the surface of platelets, monocytes, neutrophils, and some types of T-cells, and makes up a large portion of endothelial cell intercellular junctions. The encoded protein is a member of the immunoglobulin superfamily and is likely involved in leukocyte migration, angiogenesis, and integrin activation.
platelet endothelial cell adhesion molecule
, CD31 antigen
, platelet/endothelial cell adhesion molecule (CD31 antigen)
, type I transmembrane endothelial adhesion molecule