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Ccr7 functions during axis formation as a GPCR (zeige GPRC6A ELISA Kits) to inhibit beta-catenin (zeige CTNNB1 ELISA Kits), likely by promoting Ca(2 (zeige CA2 ELISA Kits)+) transients throughout the blastula.
in the current study, we used interval mapping to validate a locus on Chr 15, named Ity8, linked to Salmonella resistance in AcB60 mice. Global gene expression analysis during infection identified AcB60-specific expression of genes involved in Ccr7 signaling, including downstream effector Mapk11 (mitogen-activated protein kinase 11 (zeige MAPK11 ELISA Kits)), located within the Ity8 interval, and representing a potential positional candidate gene
Taken together, these data suggest that CCR7 biases memory CD8 (zeige CD8A ELISA Kits) T cells toward IL-7 (zeige IL7 ELISA Kits)-dependent niches over IL-15 (zeige IL15 ELISA Kits)-dependent niches, which provides insight into the homeostatic regulation of different memory T-cell subsets.
Prominent mucosal immune responses in CCR7-deficient mice increased the efficiency of bacteria clearance from the FRT(female reproductive tract) while reducing tissue-associated inflammation and pathology; increased numbers of lymphocytes within the FRT result in pathogen clearance with reduced immune-mediated pathology
CCR7 is required to mount a robust immune response against enteropathogenic Y. pseudotuberculosis by promoting Th17-like responses in mesenteric lymph nodes.
CCR7 overexpression and RelB (zeige RELB ELISA Kits) knockdown (KD) in imDCs improve skin-graft survival in a murine skin-transplantation model. Transfection with Ad-CCR7 and RelB (zeige RELB ELISA Kits) KD in imDCs may be an effective approach inducing immune tolerance, thus being potentially valuable for inhibiting allograft rejection.
data point to Ccr7 as a critical host defense restriction factor limiting neuroinflammation during acute West Nile virus infection
The results suggest that CCR7 plays a causal role in maintaining innate and adaptive immunity in obesity.
these data indicate that CCR7 and BTLA (zeige BTLA ELISA Kits) cooverexpression imparts an intermediate immune phenotype in mmature dendritic cells when compared to that in CCR7- or BTLA (zeige BTLA ELISA Kits)-expressing counterparts that show a more immunocompetent or immunotolerant phenotype
Results suggest that baicalin exerts an inhibitory effect on airway inflammation, and this effect may be associated with the inhibition of CCR7 and its ligands, CCL19 (zeige CCL19 ELISA Kits) and CCL21 (zeige CCL21 ELISA Kits), as well as on the nuclear factor-Kappa B (NF-kappaB (zeige NFKB1 ELISA Kits)) pathway in a mouse model of asthma.
This study reveals a role for CCR7 in limiting Treg recirculation back to the thymus and enables separation of the mechanisms controlling Treg production and thymic recirculation.
Report an increased percentage of peripheral CCR7 T cells accompanied by endothelial dysfunction in patients with ankylosing spondylitis.
The analysis of gene amplification and mRNA levels showed the expression of CCR7 in breast cancer correlated with better prognosis.
that CCR7 mediates TGF-beta1 (zeige TGFB1 ELISA Kits)-induced MMP2 (zeige MMP2 ELISA Kits)/9 expression through NF-kappaB (zeige NFKB1 ELISA Kits) signaling
leukocyte subsets express distinct patterns of CCR7 sialylation that contribute to receptor signaling and fine-tuning chemotactic responses.
tumor microenvironment stimulation down-regulated the migration of CCR7-expressing tumor cells toward CCL21 (zeige CCL21 ELISA Kits) and inhibited the formation of directional protrusions toward CCL21 (zeige CCL21 ELISA Kits) in a novel 3-dimensional hydrogel system.
CCR7 expression levels in human tumors correlate with signatures of CD141 (zeige THBD ELISA Kits)(+) DC, intratumoral T cells, and better clinical outcomes.
specific role for CCL21/CCR7 in promoting EMT and metastasis in CD133+ pancreatic cancer stem-like cells
This study showed that CCR7 are overexpressed in CD4 (zeige CD4 ELISA Kits)(-) CD8 (zeige CD8A ELISA Kits)(-) thymocytes of myasthenia gravis patients.
High tumoral CCR7 expression correlated with potential lymphatic involvement and poor prognosis of metastatic renal cell carcinoma patients treated with tyrosine kinase (zeige TXK ELISA Kits) inhibitors.
Results show that upregulation of CCR7 promotes cell proliferation and inflammation in A549 non-small cell lung cancer cells. However, silencing of CCR7 via siRNA treatment promotes cell apoptosis and suppresses the inflammatory response and TGF-beta1 (zeige TGFB1 ELISA Kits)-induced EMT (zeige ITK ELISA Kits), which may be associated with NF-kappaB (zeige NFKB1 ELISA Kits) signaling.
Fluorescent dye-labeled gammadelta T cells from afferent and efferent lymph lack CCR7 surface expression and display high levels of CD62L (zeige SELL ELISA Kits) compared with CD4 (zeige CD4 ELISA Kits) T cells, which do express CCR7.
CCR7 transcripts were minimally expressed in ex vivo and proliferating WC1(+)gammadelta T cells, a unique cell population with proinflammatory characteristics
the pattern of expression of CCR7 in different populations of porcine lymphocytes appears to be similar to that of human, highlighting the value of the pig as a useful animal model for biomedical studies.
Pre-translntation of sertli cell CCR7 significantly suppresses lymphocyte proliferation and prolongs allogeneic skin graft survival.
The protein encoded by this gene is a member of the G protein-coupled receptor family. This receptor was identified as a gene induced by the Epstein-Barr virus (EBV), and is thought to be a mediator of EBV effects on B lymphocytes. This receptor is expressed in various lymphoid tissues and activates B and T lymphocytes. It has been shown to control the migration of memory T cells to inflamed tissues, as well as stimulate dendritic cell maturation. The chemokine (C-C motif) ligand 19 (CCL19/ECL) has been reported to be a specific ligand of this receptor.
C-C chemokine receptor type 7
, CC chemokine receptor 7
, chemokine (C-C motif) receptor 7 a
, chemokine (C-C motif) receptor 7
, c-C chemokine receptor type 7-like
, C-C CKR-7
, EBV-induced G-protein coupled receptor 1
, MIP-3 beta receptor
, chemokine (C-C) receptor 7
, epstein-Barr virus-induced G-protein coupled receptor 1
, EBV-induced G protein-coupled receptor 1
, Epstein-Barr virus induced G-protein coupled receptor
, Epstein-Barr virus induced gene 1
, lymphocyte-specific G protein-coupled peptide receptor
, chemokine receptor 7