PTPN13 Produkte
(Protein tyrosine Phosphatase, Non-Receptor Type 13 (APO-1/CD95 (Fas)-Associated Phosphatase) (PTPN13))
Kategorien
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP is a large intracellular protein. It has a catalytic PTP domain at its C-terminus and two major structural domains: a region with five PDZ domains and a FERM domain that binds to plasma membrane and cytoskeletal elements. This PTP was found to interact with, and dephosphorylate, Fas receptor and IkappaBalpha through the PDZ domains. This suggests it has a role in Fas mediated programmed cell death. This PTP was also shown to interact with GTPase-activating protein, and thus may function as a regulator of Rho signaling pathways. Four alternatively spliced transcript variants, which encode distinct proteins, have been reported. [provided by RefSeq, Oct 2008].
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Ausgewählte PTPN13 Kategorien
PTPN13 Antikörper
High quality antibodies with extensive validation data.
PTPN13 Proteine
Proteins for various applications incl. WB, ELISA, IF etc.
Empfohlene PTPN13 Antikörper
Produkt
Reaktivität
Applikation
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human
Applikation
WB, IP, IHC (p), ICC, IHC (fro), IF
Validierungen
- (1)
- (3)
Kat. Nr.
ABIN537409
Menge
50 μL
Datenblatt
Datenblatt
Reaktivität
Human
Applikation
ELISA, IHC, IF
Validierungen
- (3)
Kat. Nr.
ABIN7174093
Menge
100 μg
Datenblatt
Datenblatt
Reaktivität
Human
Applikation
ELISA, WB, IHC (p), ICC, IHC (fro)
Validierungen
- (2)
Kat. Nr.
ABIN7444964
Menge
100 μL
Datenblatt
Datenblatt
Empfohlene PTPN13 Proteine
Produkt
Reaktivität
Source
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human
Source
Wheat germ
Validierungen
- (1)
Kat. Nr.
ABIN1316830
Menge
10 μg
Datenblatt
Datenblatt
Reaktivität
Human
Source
Escherichia coli (E. coli)
Validierungen
Kat. Nr.
ABIN7419421
Menge
100 μg
Datenblatt
Datenblatt
Reaktivität
Mouse
Source
Escherichia coli (E. coli)
Validierungen
Kat. Nr.
ABIN7419424
Menge
100 μg
Datenblatt
Datenblatt
Neueste Publikationen zu unseren PTPN13 Produkten
: "Apoptotic signalling targets the post-endocytic sorting machinery of the death receptor Fas/CD95." in: Nature communications, Vol. 10, Issue 1, pp. 3105, (2019) (PubMed).: "Capsaicin Induces Autophagy and Apoptosis in Human Nasopharyngeal Carcinoma Cells by Downregulating the PI3K/AKT/mTOR Pathway." in: International journal of molecular sciences, Vol. 18, Issue 7, (2017) (PubMed).
: "Endothelial to mesenchymal transition is common in atherosclerotic lesions and is associated with plaque instability." in: Nature communications, Vol. 7, pp. 11853, (2016) (PubMed).
: "Proteins interacting with cloning scars: a source of false positive protein-protein interactions." in: Scientific reports, Vol. 5, pp. 8530, (2015) (PubMed).
: "PTPL1 and PKCδ contribute to proapoptotic signalling in prostate cancer cells." in: Cell death & disease, Vol. 4, pp. e576, (2013) (PubMed).
: "FAP-1 association with Fas (Apo-1) inhibits Fas expression on the cell surface." in: Molecular and cellular biology, Vol. 23, Issue 10, pp. 3623-35, (2003) (PubMed).
: "Structure determination and ligand interactions of the PDZ2b domain of PTP-Bas (hPTP1E): splicing-induced modulation of ligand specificity." in: Journal of molecular biology, Vol. 334, Issue 1, pp. 143-55, (2003) (PubMed).
: "Protein-tyrosine phosphatase PTPL1/FAP-1 triggers apoptosis in human breast cancer cells." in: The Journal of biological chemistry, Vol. 277, Issue 49, pp. 47861-9, (2002) (PubMed).
: "Expression and potential role of Fas-associated phosphatase-1 in ovarian cancer." in: The American journal of pathology, Vol. 158, Issue 4, pp. 1335-44, (2001) (PubMed).
Synonyme und alternative Namen zu PTPN13
protein tyrosine phosphatase, non-receptor type 13 (PTPN13), tyrosine-protein phosphatase non-receptor type 13 (LOC100540743), protein tyrosine phosphatase, non-receptor type 13 (ptpn13), protein tyrosine phosphatase, non-receptor type 13 (Ptpn13), AI324989, FAP-1, hPTP1E, PNP1, ptp, PTP-BAS, PTP-BL, Ptp-bl, PTP1E, PTPL1, PTPLE, PTPN13, Ptpri, RIP, wu:fb50g04, zgc:162319Bezeichner auf Proteinebene für PTPN13
- fas-associated protein-tyrosine phosphatase 1
- hPTPE1
- protein-tyrosine phosphatase 1E
- protein-tyrosine phosphatase PTPL1
- tyrosine-protein phosphatase non-receptor type 13
- protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase)
- protein tyrosine phosphatase, non-receptor type 13
- tyrosine-protein phosphatase non-receptor type 13-like
- PTP36
- protein tyrosine phosphatase DPZPTP
- protein tyrosine phosphatase PTP-BL
- protein-tyrosine phosphatase RIP
- tyrosine phosphatase
- protein Tyr phosphatase
- protein-tyrosine phosphatase BAS
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