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PTPN12 Produkte

(Protein Tyrosine Phosphatase G1 (PTPN12))

Kategorien

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains a C-terminal PEST motif, which serves as a protein-protein interaction domain, and may regulate protein intracellular half-life. This PTP was found to bind and dephosphorylate the product of the oncogene c-ABL and thus may play a role in oncogenesis. This PTP was also shown to interact with, and dephosphorylate, various products related to cytoskeletal structure and cell adhesion, such as p130 (Cas), CAKbeta/PTK2B, PSTPIP1, and paxillin. This suggests it has a regulatory role in controlling cell shape and mobility. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Oct 2008].

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Ausgewählte PTPN12 Kategorien

PTPN12 Antikörper

High quality antibodies with extensive validation data.

PTPN12 Proteine

Proteins for various applications incl. WB, ELISA, IF etc.

Empfohlene PTPN12 Antikörper

Produkt
Reaktivität
Applikation
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität Human, Mouse, Rat
Applikation WB, IHC, IF
Validierungen
  • (14)
Kat. Nr. ABIN7075292
Menge 100 μL
Datenblatt Datenblatt
Reaktivität Human
Applikation WB, IHC (p), IF, ICC
Validierungen
  • (4)
Kat. Nr. ABIN2855422
Menge 100 μL
Datenblatt Datenblatt
Reaktivität Human, Mouse
Applikation WB, ELISA, IHC
Validierungen
  • (3)
Kat. Nr. ABIN7239389
Menge 200 μL
Datenblatt Datenblatt

Empfohlene PTPN12 ELISA Kits

Produkt
Reaktivität
Analytical Method
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität Human
Analytical Method Quantitative Sandwich ELISA
Validierungen
Kat. Nr. ABIN6730261
Menge 96 tests
Datenblatt Datenblatt

Empfohlene PTPN12 Proteine

Produkt
Reaktivität
Source
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität Human
Source Escherichia coli (E. coli)
Validierungen
  • (1)
Kat. Nr. ABIN7124676
Menge 50 μg
Datenblatt Datenblatt
Reaktivität Human
Source Wheat germ
Validierungen
  • (1)
Kat. Nr. ABIN1316828
Menge 10 μg
Datenblatt Datenblatt
Reaktivität Human
Source Wheat germ
Validierungen
  • (1)
Kat. Nr. ABIN1316826
Menge 10 μg
Datenblatt Datenblatt

Neueste Publikationen zu unseren PTPN12 Produkten

Cao, Chen, Luo, Zhang, Zhang, Zeng, Jiang, Han, Wen: "Tyrosine-protein phosphatase non-receptor type 12 expression is a good prognostic factor in resectable non-small cell lung cancer." in: Oncotarget, Vol. 6, Issue 13, pp. 11704-13, (2015) (PubMed).

Harris, Blaser, Moreno, Treloar, Gorrini, Sasaki, Mason, Knobbe, Rufini, Hallé, Elia, Wakeham, Tremblay, Melino, Done, Mak: "PTPN12 promotes resistance to oxidative stress and supports tumorigenesis by regulating FOXO signaling." in: Oncogene, Vol. 33, Issue 8, pp. 1047-54, (2014) (PubMed).

Rhee, Davidson, Souza, Vacher, Veillette: "Macrophage fusion is controlled by the cytoplasmic protein tyrosine phosphatase PTP-PEST/PTPN12." in: Molecular and cellular biology, Vol. 33, Issue 12, pp. 2458-69, (2013) (PubMed).

Synonyme und alternative Namen zu PTPN12

protein tyrosine phosphatase, non-receptor type 12 (PTPN12), protein tyrosine phosphatase, non-receptor type 12 (Ptpn12), P19-PTP, PTP-P19, PTP-PEST, PTPG1, Ptpg1, RKPTP

Bezeichner auf Proteinebene für PTPN12

  • protein-tyrosine phosphatase G1
  • tyrosine-protein phosphatase non-receptor type 12
  • MPTP-PEST
  • protein-tyrosine phosphatase P19
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