PTPN12 Antikörper (N-Term)

Produktnummer ABIN2855422

Produktdetails anti-PTPN12 Antikörper

Target: PTPN12 (Protein Tyrosine Phosphatase G1 (PTPN12))

Bindungsspezifität: N-Term

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PTPN12 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (IF), Immunocytochemistry (ICC)

Kreuzreaktivität: Human, Ratte

Produktmerkmale: Rabbit Polyclonal antibody to PTPN12 (protein tyrosine phosphatase, non-receptor type 12)
PTPN12 antibody [N1N2], N-term

Aufreinigung: Purified by antigen-affinity chromatography.

Immunogen: Recombinant protein encompassing a sequence within the N-terminus region of human PTPN12. The exact sequence is proprietary.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB: 1:1000-1:10000. ICC/IF: 1:100-1:1000. IHC-P: 1:100-1:1000. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.

Kommentare:

Positive Control: HeLa

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.93 mg/mL

Buffer: 0.1M Tris-Glycine ( pH 7), 20 % Glycerol, 0.01 % Thimerosal

Konservierungsmittel: Thimerosal (Merthiolate)

Vorsichtsmaßnahmen: This product contains Thimerosal (Merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.

Details zu PTPN12

Target: PTPN12 (Protein Tyrosine Phosphatase G1 (PTPN12))

Andere Bezeichnung: protein tyrosine phosphatase non-receptor type 12 (PTPN12 Produkte)

Synonyme: PTP-PEST antikoerper, PTPG1 antikoerper, P19-PTP antikoerper, PTP-P19 antikoerper, Ptpg1 antikoerper, RKPTP antikoerper, protein tyrosine phosphatase, non-receptor type 12 antikoerper, PTPN12 antikoerper, Ptpn12 antikoerper

Hintergrund: The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains a C-terminal PEST motif, which serves as a protein-protein interaction domain, and may regulate protein intracellular half-life. This PTP was found to bind and dephosphorylate the product of the oncogene c-ABL and thus may play a role in oncogenesis. This PTP was also shown to interact with, and dephosphorylate, various products related to cytoskeletal structure and cell adhesion, such as p130 (Cas), CAKbeta/PTK2B, PSTPIP1, and paxillin. This suggests it has a regulatory role in controlling cell shape and mobility. Alternative splicing results in multiple transcript variants encoding distinct isoforms.

Cellular Localization: Cytoplasm

Molekulargewicht: 88 kDa

Gen-ID: 5782

UniProt: Q05209