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Human SLC9A3R1 Protein expressed in HEK-293 Cells - ABIN2732190
Wang, Qin, Zhu: Expression of Na+/H+ exchanger regulatory factor 1 in autosomal-dominant polycystic kidney disease. in The Journal of international medical research 2015
Na+/H+ exchanger regulatory factor (NHERF1) expression level positively associates with G protein-coupled estrogen receptor (GPER) activation in ER-positive breast cancer.
The present results suggest a role for NHERF1 in the progression of breast cancer mediated by the nuclear distribution of the NHERF1 protein, as determined by the truncation or key site mutation of the PDZ-I domain.
NF2 (zeige NF2 Proteine) localizes in nucleus when Ser518 is not phosphorylated, while phosphorylated form is present in cytoplasm and plasma membrane. Data suggest that binding of NF2 (zeige NF2 Proteine) to TIMAP (zeige PPP1R16B Proteine) and EBP50 is critical in nuclear localization of NF2 (zeige NF2 Proteine). (NF2 (zeige NF2 Proteine) = neurofibromin 2 (zeige NF2 Proteine); TIMAP (zeige PPP1R16B Proteine) = TGF-beta-inhibited membrane-associated protein (zeige PPP1R16B Proteine); EBP50 = Ezrin (zeige EZR Proteine)-Radixin (zeige RDX Proteine)-Mosein binding phosphoprotein 50)
NHERF1/EBP50 encompasses the regulation of several major signaling pathways engaged in cancer, including the receptor tyrosine kinases PDGFR (zeige PDGFRB Proteine) and EGFR (zeige EGFR Proteine), PI3K (zeige PIK3CA Proteine)/PTEN/AKT (zeige AKT1 Proteine) and Wnt (zeige WNT2 Proteine)-beta-catenin (zeige CTNNB1 Proteine) pathways.
Data demonstrated that EBP50 overexpression inhibited the adhesion and migration of breast and cervical cancer cell lines and suppressed MMP-2 (zeige MMP2 Proteine) activity in these cells; while its knockdown promoted cell adhesion and migration, and enhanced the activity of MMP-2 (zeige MMP2 Proteine).This study reveals the anti-metastatic effect and a new mechanism of EBP50 action in breast and cervical cancer cells.
Data provide evidence for an important role of NHERF1 in the epithelial-mesenchymal transition of non-small-cell lung cancer cells, as well as migration.
This interaction is promoted by EPAC1 (zeige RAPGEF3 Proteine) activation, triggering its translocation to the plasma membrane and binding to NHERF1. Our findings identify a new CFTR (zeige CFTR Proteine)-interacting protein and demonstrate that cAMP activates CFTR (zeige CFTR Proteine) through two different but complementary pathways - the well-known PKA-dependent channel gating pathway and a new mechanism regulating endocytosis that involves EPAC1 (zeige RAPGEF3 Proteine).
we show here that NHERF1 loss from the PM is oncogenic in vivo through its influence on Wnt (zeige WNT2 Proteine)-APC (zeige APC Proteine)-beta-catenin (zeige CTNNB1 Proteine) and Hippo-YAP (zeige YAP1 Proteine) pathways.
High EBP50 expression is associated with cervical cancer.
Using neutron spin echo spectroscopy (NSE (zeige ENO2 Proteine)), the authors show salt-concentration-dependent excitation of nanoscale motion at the tip of the C-terminal tail in the phosphomimic S339D/S340D mutant.
Along with several single loci, the epistatic QTLs, SLC9A3R1 and NOS2 control for total number of piglets born and number of piglets born alive in a F(2) Iberian by Meishan intercross.
Results strongly support an important role for NHERF1 (zeige SLC9A3R2 Proteine) in the regulation of Planar Cell Polarity signaling and the development of functional motile cilia.
our data identify EBP50 as a previously unidentified regulator of Nox1 (zeige NOX1 Proteine) and support that it promotes Nox1 (zeige NOX1 Proteine) activity by binding p47(phox) This interaction is pivotal for agonist-induced smooth muscle ROS (zeige ROS1 Proteine), hypertrophy, and vasoconstriction and has implications for ROS (zeige ROS1 Proteine)-mediated physiological and pathophysiological processes.
The results provide evidence that NHERF1 (zeige SLC9A3R2 Proteine) mediates K(+) current activity through acceleration of the surface expression of ROMK1 (zeige KCNJ1 Proteine) K(+) channels in M-1 cells.
The NHERF1 (zeige SLC9A3R2 Proteine) is as putative molecular organizer of signal transduction in vomeronasal neurons.
we show here that NHERF1 (zeige SLC9A3R2 Proteine) loss from the PM is oncogenic in vivo through its influence on Wnt (zeige WNT2 Proteine)-APC (zeige APC Proteine)-beta-catenin (zeige CTNNB1 Proteine) and Hippo-YAP (zeige YAP1 Proteine) pathways.
NHERF1 (zeige SLC9A3R2 Proteine) mediates ANG II (zeige AGT Proteine)-induced activation of renal NHE3 (zeige SLC9A3 Proteine), which requires coordination between IRBIT (zeige AHCYL1 Proteine) and the NHERF1 (zeige SLC9A3R2 Proteine) PDZ1 domain in binding and transporting NHE3 (zeige SLC9A3 Proteine)
These results indicate that PTH-mediated inhibition of renal phosphate transport involves phosphorylation of S77 of the NHERF-1 PDZ I domain and the dissociation of NHERF-1/Npt2a complexes.
the activation of PTEN and NHERF-1 may impede the evolution of macrophages beyond the M1 into M2 phenotype in tumor microenvironment.
Data show that interaction of the inducible nitric oxide synthase (iNOS (zeige NOS2 Proteine)) C-terminus with the PDZ domains of EBP50 protein or Pdzk1 (zeige PDZK1 Proteine) protein CAP70 (zeige PDZK1 Proteine) resulted greater nitric oxide (NO) synthesis.
The expression of EBP50 was not significantly different in the pseudopregnant uterus and decreased in the uteri subjected to activation of delayed implantation.
study found mainly nuclear localization of EBP50 in interphase cells, and its redistribution to cytoplasm during mitosis parallel with its phosphorylation; PP2A (zeige PPP2R2B Proteine) was identified as an interacting protein of EBP50 during pro-, prometa-, meta-, ana (zeige BTG3 Proteine)-, telophase, and early cytokinesis
This gene encodes a sodium/hydrogen exchanger regulatory cofactor. The protein interacts with and regulates various proteins including the cystic fibrosis transmembrane conductance regulator and G-protein coupled receptors such as the beta2-adrenergic receptor and the parathyroid hormone 1 receptor. The protein also interacts with proteins that function as linkers between integral membrane and cytoskeletal proteins. The protein localizes to actin-rich structures including membrane ruffles, microvilli, and filopodia. Mutations in this gene result in hypophosphatemic nephrolithiasis/osteoporosis type 2, and loss of heterozygosity of this gene is implicated in breast cancer.
Na(+)/H(+) exchange regulatory cofactor NHE-RF1
, Na+/H+ exchange regulatory co-factor
, ezrin-radixin-moesin binding phosphoprotein-50
, ezrin-radixin-moesin-binding phosphoprotein 50
, regulatory cofactor of Na(+)/H(+) exchanger
, solute carrier family 9 (sodium/hydrogen exchanger), isoform 3 regulatory factor 1
, solute carrier family 9 isoform A3 regulatory factor 1
, sodium-hydrogen exchanger regulatory factor 1
, solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 1
, solute carrier family 9 sodium/hydrogen exchanger member 3 regulator 1
, solute carrier family 9 (sodium/hydrogen exchanger), isoform 3 regulatory factor 2
, solute carrier family 9 (sodium/hydrogen exchanger), isoform 3 regulator 1
, ERM-binding phosphoprotein
, Na(+)/H(+) exchange regulatory cofactor NHE-RF
, solute carrier family 9 isoform 3 regulatory factor 1
, NHE3 kinase A regulatory protein 1
, SLC9A3 regulator 1 S homeolog
, solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1 S homeolog